Drug General Information (ID: DDIXSVCBJ6)
Drug Name			Sodium bicarbonate		Drug Info		Dabrafenib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiarrheals				Multikinase Inhibitors
Structure

Mechanism of Sodium bicarbonate-Dabrafenib Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Sodium bicarbonate				Dabrafenib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Dabrafenib due to altered gastric pH caused by Sodium bicarbonate

Recommended Action
Management		Until more information is available, caution is advised if dabrafenib is used in combination with H2-receptor antagonists or antacids. The potential for diminished therapeutic effects of dabrafenib should be considered, and pharmacologic response should be closely monitored.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Product Information. Aciphex (rabeprazole) Janssen Pharmaceuticals, Titusville, NJ.
4	Product Information. Dexilant (dexlansoprazole). Takeda Pharmaceuticals America, Lincolnshire, IL.
5	Product Information. Prevacid (lansoprazole). TAP Pharmaceuticals Inc, Deerfield, IL.
6	Product Information. Tafinlar (dabrafenib). GlaxoSmithKline, Research Triangle Park, NC.
7	Product Information. Zantac (ranitidine). Glaxo Wellcome, Research Triangle Park, NC.