Drug General Information (ID: DDILXF4Z0T)
Drug Name			Sodium bicarbonate		Drug Info		Nilotinib		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antidiarrheals				Antineoplastics
Structure

Mechanism of Sodium bicarbonate-Nilotinib Interaction (Severity Level: Moderate)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Sodium bicarbonate				Nilotinib
Mechanism		Gastric alkalinizer				Gastric pH sensitive
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Nilotinib due to altered gastric pH caused by Sodium bicarbonate

Recommended Action
Management		Patients treated with nilotinib should not take antacids or other agents with acid-neutralizing effects for at least 2 hours before or 2 hours after a nilotinib dose.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".