Drug General Information (ID: DDIEUD821C)
Drug Name			Delavirdine		Drug Info		Sodium bicarbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antidiarrheals
Structure

Mechanism of Delavirdine-Sodium bicarbonate Interaction (Severity Level: Moderate)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Delavirdine				Sodium bicarbonate
Mechanism		Delavirdine				Decrease absorption of delavirdine
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Delavirdine caused by Sodium bicarbonate

Recommended Action
Management		Delavirdine administration should be separated by at least 1 hour from one of these preparations.

References
1	Product Information. Rescriptor (delavirdine). Pharmacia and Upjohn, Kalamazoo, MI.