Drug General Information (ID: DDI2P7I41E)
Drug Name			Proguanil		Drug Info		Sodium bicarbonate		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antimalarial Agents				Antidiarrheals
Structure

Mechanism of Proguanil-Sodium bicarbonate Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Proguanil				Sodium bicarbonate
Mechanism		Adsorbed by antacids				Antacid
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Proguanil due to adsorption of Sodium bicarbonate

Recommended Action
Management		Antacids or antidiarrheals and proguanil should be taken at least 2 to 3 hours apart.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.