Details of Drug

Details of Drug

 Drug General Information (ID: D1350)
  Drug Name
Proguanil
  Drug Type Small molecule
  Drug Synonymous
Bigumal; Chlorguanid; Chlorguanide; Chloriguane; Chloroguanide; Paludrin; Proguanile; Proguanilum; Proguanile [DCIT]; Diguanyl (hydrochloride); Drinupal (hydrochloride); Paludrine (TN); Paludrine (hydrochloride); Palusil (hydrochloride); Proguanil [INN:BAN]; Proguanilum [INN-Latin]; RP-3359; Tirian (hydrochloride); M-4888 (hydrochloride); SN-12837 (hydrochloride); N1-p-Chlorophenyl-N5-isopropylbiguanide; N-(4-Chlorophenyl)-N'-(1-methylethyl)imidodicarbonimidic diamide; N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide; N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide; (1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine; 1-(p-Chlorophenyl)-5-isopropylbiguanide; 1-Isopropyl-5-(4-chlorophenyl)biguanide
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  Disease Class 1F40-1F45: Malaria
  Therapeutic Class Antimalarial Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C11H16ClN5
  InChI 1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)
  InChIKey SSOLNOMRVKKSON-UHFFFAOYSA-N
  Canonical SMILES CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl
  External Link
Pubchem ID 6178111
CAS Number 500-92-5
CHEBI ID 8455
TTD ID D0P8RS
INTEDE ID DR1347

Drug-Drug Interaction Network
  Sunburst Graph
AM001  Affected gastrointestinal absorption
AM003  Affected organization distribution
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM003  Complex formation
BM004  Adsorption
BM014  Interference of cell/tissue uptake
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM026  Increased metabolism (Unspecific)
BM043  Additive immunosuppressive effects
BM044  Additive myelosuppressive effects
BM100  Antagonize the effect of vaccine/toxoid
BM107  Attenuated pharmacological effects (Unspecific)
  Relation Graph
 Full list of drugs interacting with Proguanil
      Affected gastrointestinal absorption
   Complex formation Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1369
 
Quinapril
 
C25H30N2O5
 
54892 
Moderate    Inter Info   
[10], [16]
   Adsorption Drug Num:  6
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0049
 
Aluminum hydroxide
 
AlH3O3
 
10176082 
Moderate    Inter Info   
[10], [16]
D0236
 
Calcium carbonate
 
CCaO3
 
10112 
Moderate    Inter Info   
[10], [16], [8]
D0877
 
Kaolin
 
Al2H4O9Si2
 
56841936 
Moderate    Inter Info   
[10], [16], [8]
D0967
 
Magaldrate
 
AlHMgO5S+2
 
3086011 
Moderate    Inter Info   
[10], [16], [8]
D0973
 
Magnesium hydroxide
 
H2MgO2
 
14791 
Moderate    Inter Info   
[10], [16]
D1480
 
Sodium bicarbonate
 
CHNaO3
 
516892 
Moderate    Inter Info   
[10], [16]
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1822
 
Iodide I-123
 
I-
 
135300 
Moderate    Inter Info   
[23], [24], [25]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  9
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0087
 
Anisindione
 
C16H12O3
 
2197 
Moderate    Inter Info   
[6], [7], [8]
D0481
 
Dicoumarol
 
C19H12O6
 
54676038 
Moderate    Inter Info   
[6], [7], [8]
D0642
 
Fenofibrate
 
C20H21ClO4
 
3339 
Moderate    Inter Info   
[9], [10], [11]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Moderate    Inter Info   
[9], [12], [13], [14], [15]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Moderate    Inter Info   
[9], [12], [13], [14], [15]
D0300
 
Cenobamate
 
C10H10ClN5O2
 
11962412 
Moderate    Inter Info   
[18]
D0638
 
Fedratinib
 
C27H36N6O3S
 
16722836 
Moderate    Inter Info   
[10], [21]
D1711
 
Warfarin
 
C19H16O4
 
54678486 
Moderate    Inter Info   
[6], [7]
D0208
 
Brivaracetam
 
C11H20N2O2
 
9837243 
Minor    Inter Info   
[10], [29]
   CYP450 enzyme induction Drug Num:  4
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Major    Inter Info   
[4], [5]
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[10], [17]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[19], [9], [10], [20]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Moderate    Inter Info   
[27], [5]
   Increased metabolism (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1802
 
Glucarpidase
 
Zn4+8
 
21195079 
Moderate    Inter Info   
[10], [22]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1366
 
Pyrimethamine
 
C12H13ClN4
 
4993 
Moderate    Inter Info   
[10], [16]
   Additive myelosuppressive effects Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0126
 
Auranofin
 
C20H34AuO9PS
 
24199313 
Major    Inter Info   
[1], [2], [3]
D0127
 
Aurothioglucose
 
C6H11AuO5S
 
454937 
Major    Inter Info   
[1], [2], [3]
D1479
 
Sodium aurothiomalate
 
C4H3AuNa2O4S
 
22318 
Major    Inter Info   
[1], [2], [3]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of vaccine/toxoid Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1914
 
Typhoid vaccine (live)
 
NA
 
NA
Moderate    Inter Info   
[6], [8], [26]
   Attenuated pharmacological effects (Unspecific) Drug Num:  1
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1884
 
Sapropterin
 
C9H15N5O3
 
135398654 
Moderate    Inter Info   
[9], [28]
References
1 Product Information. Myochrysine (gold sodium thiomaleate). Merck &amp Co, Inc, West Point, PA.
2 Product Information. Ridaura (auranofin). SmithKline Beecham, Philadelphia, PA.
3 Product Information. Solganal (aurothioglucose). Schering Laboratories, Kenilworth, NJ.
4 Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
5 Van Luin M, Van der Ende ME, Richter C, et al. "Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir." AIDS 24 (2010): 1223-6. [PMID: 20299957]
6 Product Information. Malarone (atovaquone-proguanil) Glaxo Wellcome, Research Triangle Pk, NC.
7 Warfarin potentiated by proguanil. BMJ 303 (1991): 789. [PMID: 1932962]
8 Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
9 Cerner Multum, Inc. "Australian Product Information.".
10 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
11 Product Information. Antara (fenofibrate). Lupin Pharmaceuticals Inc, Baltimore, MD.
12 Dequardo JR "Modafinil-associated clozapine toxicity." Am J Psychiatry 159 (2002): 1243-1244. [PMID: 12091210]
13 Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
14 Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
15 Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]
16 Multum Information Services, Inc. Expert Review Panel.
17 Product Information. Erleada (apalutamide). Janssen Biotech, Inc., Horsham, PA, PA.
18 Product Information. Xcopri (cenobamate). SK Life Science, Inc., Paramus, NJ.
19 Benoist G, van Oort I, et al "Drug-drug interaction potential in men treated with enzalutamide: Mind the gap." Br J Clin Pharmacol 0 (2017): epub. [PMID: 28881501]
20 Product Information. Xtandi (enzalutamide). Astellas Pharma US, Inc, Deerfield, IL.
21 Product Information. Inrebic (fedratinib). Celgene Corporation, Summit, NJ.
22 Product Information. Voraxaze (glucarpidase). BTG International Inc, West Conshohocken, PA.
23 Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
24 Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
25 Product Information. Sodium Iodide I-123 (sodium iodide I-123). GE Healthcare, Princeton, NJ.
26 Product Information. Vivotif Berna (typhoid vaccine, live) Crucell Vaccine Inc, Coral Gables, FL.
27 Product Information. Norvir (ritonavir). Abbott Pharmaceutical, Abbott Park, IL.
28 Product Information. Kuvan (sapropterin). BioMarin Pharmaceutical Inc, Novato, CA.
29 Product Information. Briviact (brivaracetam). UCB Pharma Inc, Smyrna, GA.