Drug General Information (ID: DDIJKT45QP)
Drug Name			Proguanil		Drug Info		Typhoid vaccine (live)		Drug Info
Drug Type		Small molecule				Vaccine
Therapeutic Class		Antimalarial Agents				Vaccine

Mechanism of Proguanil-Typhoid vaccine (live) Interaction (Severity Level: Moderate)
Antagonize the effect of vaccine/toxoid Click to Show/Hide Mechanism Graph
Drug Name		Proguanil				Typhoid vaccine (live)
Mechanism		Impairs immunomodulatory bacterial infective agent				Immunomodulatory infective agent
Key Mechanism Factor 1
		Factor Name		Vaccine/toxoid
		Factor Description		The beneficial effects of the vaccine/toxinoid may be reduced, leading to a diminished or suboptimal immune response.
Mechanism Description		Antagonize the effect of Typhoid vaccine (live) when combined with Proguanil

Recommended Action
Management		Medications containing proguanil should not be administered until at least 10 days after the last dose of live attenuated typhoid vaccine.

References
1	Product Information. Malarone (atovaquone-proguanil) Glaxo Wellcome, Research Triangle Pk, NC.
2	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]
3	Product Information. Vivotif Berna (typhoid vaccine, live) Crucell Vaccine Inc, Coral Gables, FL.