Drug General Information (ID: DDI2COKQY1)
Drug Name			Proguanil		Drug Info		Kaolin		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antimalarial Agents				Herbal Products
Structure

Mechanism of Proguanil-Kaolin Interaction (Severity Level: Moderate)
Adsorption Click to Show/Hide Mechanism Graph
Drug Name		Proguanil				Kaolin
Mechanism		Adsorbed by adsorbent antidiarrheal agents				Adsorbent antidiarrheal agents
Key Mechanism Factor 1
		Factor Name		Adsorption
		Factor Description		Adsorption is a direct drug interaction, usually through adsorption on its surface, resulting in reduced absorption of concomitantly administered drugs in the gastrointestinal tract.
Mechanism Description		Decreased absorption of Proguanil due to adsorption of Kaolin

Recommended Action
Management		Antacids or antidiarrheals and proguanil should be taken at least 2 to 3 hours apart.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]