Details of Drug

Drug General Information (ID: D0858)
Drug Name	Isoniazid
Drug Type	Small molecule
Drug Synonymous	Abdizide; Andrazide; Anidrasona; Antimicina; Antituberkulosum; Armacide; Armazid; Armazide; Atcotibine; Azuren; Bacillen; Bacillin; Cedin; Cemidon; Chemiazid; Chemidon; Continazine; Cortinazine; Cotinazin; Cotinizin; Defonin; Dibutin; Diforin; Dinacrin; Ditubin; Ebidene; Eralon; Ertuban; Eutizon; Evalon; Fetefu; Fimalene; HIA; Hidranizil; Hidrasonil; Hidrulta; Hidrun; Hycozid; Hydra; Hydrazid; Hydrazide; Hyozid; Hyzyd; INH; Idrazil; Inah; Inizid; Iscotin; Isidrina; Ismazide; Isobicina; Isocid; Isocidene; Isocotin; Isohydrazide; Isokin; Isolyn; Isonerit; Isonex; Isoniacid; Isoniazida; Isoniazide; Isoniazidum; Isonicazide; Isonicid; Isonico; Isonicotan; Isonicotil; Isonicotinhydrazid; Isonicotinohydrazide; Isonide; Isonidrin; Isonikazid; Isonilex; Isonin; Isonindon; Isonirit; Isoniton; Isonizida; Isonizide; Isotamine; Isotebe; Isotebezid; Isotinyl; Isozid; Isozide; Isozyd; LANIZID; Laniazid; Laniozid; Mybasan; Neoteben; Neoxin; Neumandin; Nevin; Niadrin; Nicazide; Nicetal; Nicizina; Niconyl; Nicotibina; Nicotibine; Nicotisan; Nicozide; Nidaton; Nidrazid; Nikozid; Niplen; Nitadon; Niteban; Nydrazid; Nyscozid; Pelazid; Percin; Phthisen; Pycazide; Pyreazid; Pyricidin; Pyridicin; Pyrizidin; Raumanon; Razide; Retozide; Rimicid; Rimifon; Rimiphone; Rimitsid; Robiselin; Robisellin; Roxifen; Sanohidrazina; Sauterazid; Sauterzid; Stanozide; Tebecid; Tebemid; Tebenic; Tebexin; Tebilon; Tebos; Teebaconin; Tekazin; Tibazide; Tibemid; Tibiazide; Tibinide; Tibison; Tibivis; Tibizide; Tibusan; Tisin; Tisiodrazida; Tizide; Tubazid; Tubazide; Tubeco; Tubecotubercid; Tubercid; Tuberian; Tubicon; Tubilysin; Tubizid; Tubomel; Tyvid; Unicocyde; Unicozyde; Vazadrine; Vederon; Zidafimia; Zinadon; Zonazide; Hid rasonil; Isoco tin; Isoniazid SA; Isozid e; Nidra zid; Rimif on; BP 5015; Bp 5 015; FSR 3; I0138; INHd20; L 1945; Nitebannsc 9659; Preparation 6424; RP 5015; AZT + Isoniazid; Cedin (Aerosol); Dow-Isoniazid; FRS-3; FSR-3; Ido-tebin; In-73; Inh-Burgthal; Isoniazid & EEP; Isoniazid & Propolis; Laniazid (TN); Neo-Tizide; Nydrazid (TN); RP-5015; TB-Phlogin; TB-Razide; TB-Vis; Usaf cb-2; I.A.I; RU-EF-Tb; RY-EF-Tb; I.A.I. Click to Show/Hide
Disease Class	1B10-1B14: HIV-infected patients with tuberculosis
Therapeutic Class	Antitubercular Agents
Structure
Structure	3D Structure		2D Structure
Formula	C6H7N3O
InChI	1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
InChIKey	QRXWMOHMRWLFEY-UHFFFAOYSA-N
Canonical SMILES	C1=CN=CC=C1C(=O)NN
External Link
	Pubchem ID	3767
	CAS Number	54-85-3
	CHEBI ID	6030
	TTD ID	D09XQF
	INTEDE ID	DR0886
	VARIDT ID	DR00422

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM009 Altered absorption (Unspecific) BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM025 Decreased metabolism (Unspecific) BM031 Increased renal excretion (Unspecific) BM038 Additive CNS depression effects BM040 Additive dopaminergic effects BM042 Additive hypotensive effects BM046 Additive serotonergic effects BM055 Increased risk of hepatotoxicity BM072 Increased risk of nephrotoxicity BM074 Increased risk of peripheral neuropathy BM075 Increased risk of photosensitivity reactions BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM100 Antagonize the effect of vaccine/toxoid BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Isoniazid
Affected gastrointestinal absorption
	Altered absorption (Unspecific)					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Minor		Inter Info	[337], [338]
D0125		Attapulgite	Al2H29Mg2O15Si4-	56842194	Minor		Inter Info	[337], [338]
D0877		Kaolin	Al2H4O9Si2	56841936	Minor		Inter Info	[337], [338]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Minor		Inter Info	[337], [338]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[238]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 147
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0345		Citalopram	C20H21FN2O	2771	Major		Inter Info	[1], [2], [3]
D0749		Halofantrine	C26H30Cl2F3NO	37393	Major		Inter Info	[4], [5], [6], [7], [8]
D0901		Lemborexant	C22H20F2N4O2	56944144	Major		Inter Info	[16], [17]
D0909		Levacetylmethadol	C23H31NO2	15130	Major		Inter Info	[18], [19]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[20]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Major		Inter Info	[19]
D1292		Pimozide	C28H29F2N3O	16362	Major		Inter Info	[16], [23], [24], [25], [26], [27], [28], [29], [30]
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[35], [36], [37], [38], [39], [40], [41], [42]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[54], [55], [31], [56], [57], [58], [59], [60], [61], [62], [63], [64], [65], [66], [67], [68], [69]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[70], [71]
D0084		Anagrelide	C10H7Cl2N3O	135409400	Moderate		Inter Info	[72]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[87]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[88]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[93], [94], [95], [96], [97]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[98]
D0308		Cevimeline	C10H17NOS	83898	Moderate		Inter Info	[99]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[70], [71]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[100]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[70], [71]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[31], [70], [71]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[108], [65]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[70], [71]
D0481		Dicoumarol	C19H12O6	54676038	Moderate		Inter Info	[109], [110], [111]
D0513		Dofetilide	C19H27N3O5S2	71329	Moderate		Inter Info	[113]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[114], [115], [116], [117]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[120]
D0593		Ergotamine	C33H35N5O5	8223	Moderate		Inter Info	[125], [126], [127], [128], [129], [24], [130], [131], [132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144], [145], [146], [147], [148]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[149]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[16], [31], [150], [151], [152], [153], [154]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[155], [156], [157], [158], [68]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[70], [71]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[159], [160]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[70], [71]
D0845		Irinotecan	C33H38N4O6	60838	Moderate		Inter Info	[13], [16], [31], [165], [166], [167], [168]
D0846		Irinotecan (liposomal)	C33H38N4O6	60838	Moderate		Inter Info	[16], [31], [165]
D0008		Acalabrutinib	C26H23N7O2	71226662	Moderate		Inter Info	[169], [65]
D0043		Alosetron	C17H18N4O	2099	Moderate		Inter Info	[170]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[171], [172], [173], [174]
D0087		Anisindione	C16H12O3	2197	Moderate		Inter Info	[109], [110], [111], [175]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[176]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[177]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[178]
D0129		Avapritinib	C26H27FN10	118023034	Moderate		Inter Info	[31], [179]
D0195		Bosutinib	C26H29Cl2N5O3	5328940	Moderate		Inter Info	[31], [181]
D0204		Brigatinib	C29H39ClN7O2P	68165256	Moderate		Inter Info	[16], [31], [184]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[185], [16], [31], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D0216		Budesonide (nasal)	C25H34O6	5281004	Moderate		Inter Info	[185], [16], [31]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[31], [200]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[201]
D0336		Cilostazol	C20H27N5O2	2754	Moderate		Inter Info	[202], [203], [204], [205], [206], [207], [208], [209], [210]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[70], [71]
D0376		Cobimetinib	C21H21F3IN3O2	16222096	Moderate		Inter Info	[211]
D0534		Dronedarone	C31H44N2O5S	208898	Moderate		Inter Info	[212]
D0542		Dutasteride	C27H30F6N2O2	6918296	Moderate		Inter Info	[213]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[214]
D0559		Eliglustat	C23H36N2O4	23652731	Moderate		Inter Info	[215]
D0577		Entrectinib	C31H34F2N6O2	25141092	Moderate		Inter Info	[216]
D0592		Ergometrine	C19H23N3O2	443884	Moderate		Inter Info	[131], [133], [144]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[13], [16], [31], [217], [218], [219], [220], [221], [222], [223], [224], [225], [226]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[70], [71]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[227], [65]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[31], [228], [229]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[230]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[231]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[16], [31], [150], [151], [152], [153], [154]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[31], [232]
D0725		Glasdegib	C21H22N6O	25166913	Moderate		Inter Info	[233]
D0739		Grazoprevir	C38H50N6O9S	44603531	Moderate		Inter Info	[182], [234]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[31], [235]
D0785		Ibrutinib	C25H24N6O2	24821094	Moderate		Inter Info	[236], [65]
D0868		Ivabradine	C27H36N2O5	132999	Moderate		Inter Info	[31], [240]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[241], [242]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[243]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[16], [31], [244]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[245]
D0905		Lesinurad	C17H14BrN3O2S	53465279	Moderate		Inter Info	[246]
D0916		Levobupivacaine	C18H28N2O	92253	Moderate		Inter Info	[31], [247]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[248]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[249]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[16], [31], [250], [65]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[251]
D0966		Macitentan	C19H20Br2N6O4S	16004692	Moderate		Inter Info	[252]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[253]
D1062		Midostaurin	C35H30N4O4	9829523	Moderate		Inter Info	[254], [255]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[256]
D1189		Osilodrostat	C13H10FN3	44139752	Moderate		Inter Info	[31], [257]
D1190		Osimertinib	C28H33N7O2	71496458	Moderate		Inter Info	[258]
D1191		Ospemifene	C24H23ClO2	3036505	Moderate		Inter Info	[259]
D1201		Oxtriphylline	C12H21N5O3	656652	Moderate		Inter Info	[171], [172], [173], [174]
D1214		Palbociclib	C24H29N7O2	5330286	Moderate		Inter Info	[31], [260]
D1221		Panobinostat	C21H23N3O2	6918837	Moderate		Inter Info	[261], [262]
D1242		Pemigatinib	C24H27F2N5O4	86705695	Moderate		Inter Info	[31], [263]
D1290		Pimavanserin	C25H34FN3O2	10071196	Moderate		Inter Info	[267]
D1299		Pirfenidone	C12H11NO	40632	Moderate		Inter Info	[31], [268], [269]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[270]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[70], [71]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[271]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[16], [31], [272]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[16], [31], [276]
D1404		Rilpivirine	C22H18N6	6451164	Moderate		Inter Info	[16], [277], [31], [278]
D1409		Ripretinib	C24H21BrFN5O2	71584930	Moderate		Inter Info	[16], [279]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[31], [280], [281]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[31], [283]
D1460		Selumetinib	C17H15BrClFN4O3	10127622	Moderate		Inter Info	[284]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[285]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[286]
D1496		Sonidegib	C26H26F3N3O3	24775005	Moderate		Inter Info	[287]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[16], [288]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[289]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[290]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[292], [293]
D1663		Ubrogepant	C29H26F3N5O3	68748835	Moderate		Inter Info	[295]
D1688		Venetoclax	C45H50ClN7O7S	49846579	Moderate		Inter Info	[16], [31], [296]
D1718		Zanubrutinib	C27H29N5O3	135565884	Moderate		Inter Info	[297]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[16], [31], [150], [151], [152], [153], [154]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[299], [300], [301], [302], [303], [304], [305], [306]
D1037		Methylergometrine	C20H25N3O2	8226	Moderate		Inter Info	[131], [133], [144]
D1043		Methysergide	C21H27N3O2	9681	Moderate		Inter Info	[131], [133], [144]
D1063		Mifepristone	C29H35NO2	55245	Moderate		Inter Info	[307], [308]
D1087		Montelukast	C35H36ClNO3S	5281040	Moderate		Inter Info	[309], [310]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[13], [16], [31]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[16], [31], [312]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[16], [31], [150], [151], [152], [153], [154]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[315], [316]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[317], [318], [319], [320]
D1527		Tadalafil	C22H19N3O4	110635	Moderate		Inter Info	[321]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[171], [172], [173], [174]
D1612		Toremifene	C26H28ClNO	3005573	Moderate		Inter Info	[324]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[70], [71]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[325], [65]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[16], [31], [326]
D1711		Warfarin	C19H16O4	54678486	Moderate		Inter Info	[109], [110], [111], [175]
D0516		Donepezil	C24H29NO3	3152	Minor		Inter Info	[331], [269], [332], [333]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[16], [339], [340]
D0515		Dolutegravir	C20H19F2N3O5	54726191	Minor		Inter Info	[341]
D0518		Doravirine	C17H11ClF3N5O3	58460047	Minor		Inter Info	[342]
D0948		Lopinavir	C37H48N4O5	92727	Minor		Inter Info	[31], [328], [343]
D1074		Mirabegron	C21H24N4O2S	9865528	Minor		Inter Info	[344]
D1104		Naloxegol	C34H53NO11	56959087	Minor		Inter Info	[345]
D1265		Phenobarbital	C12H12N2O3	4763	Minor		Inter Info	[346]
D1394		Retapamulin (topical)	C30H47NO4S	6918462	Minor		Inter Info	[347]
D1434		Ruxolitinib	C17H18N6	25126798	Minor		Inter Info	[31], [351]
D1664		Ulipristal	C28H35NO3	13559281	Minor		Inter Info	[31], [353]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[16], [339], [340]
D1291		Pimecrolimus (topical)	C43H68ClNO11	6509979	Minor		Inter Info	[354]
D1428		Ropivacaine	C17H26N2O	175805	Minor		Inter Info	[363], [364], [365], [366], [367], [368], [369]
D1726		Ziprasidone	C21H21ClN4OS	60854	Minor		Inter Info	[370], [371], [372], [373]
	CYP450 enzyme induction					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0011		Acetaminophen	C8H9NO2	1983	Moderate		Inter Info	[46], [47], [48], [49], [50]
D0233		Calcifediol	C27H44O2	5283731	Moderate		Inter Info	[89], [90], [91], [92]
D0234		Calcitriol	C27H44O3	5280453	Moderate		Inter Info	[89], [90], [91], [92]
D0328		Cholecalciferol	C27H44O	5280795	Moderate		Inter Info	[89], [90], [91], [92]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[102], [103], [104], [105], [106], [107]
D0591		Ergocalciferol	C28H44O	5280793	Moderate		Inter Info	[89], [90], [91], [92]
D0495		Dihydrotachysterol	C28H46O	5311071	Moderate		Inter Info	[89], [90], [91], [92]
D0527		Doxercalciferol	C28H44O2	5281107	Moderate		Inter Info	[89], [90], [91], [92]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[16], [239], [30]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[16], [239], [30]
D1226		Paricalcitol	C27H44O3	5281104	Moderate		Inter Info	[89], [90], [91], [92]
	Competitive inhibition of metabolic enzyme					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0799		Indinavir	C36H47N5O4	5362440	Minor		Inter Info	[335]
D0001		Abacavir	C14H18N6O	441300	Minor		Inter Info	[336]
	Decreased metabolism (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0750		Haloperidol	C21H23ClFNO2	3559	Minor		Inter Info	[334]
D1576		Thiothixene	C23H29N3O2S2	941651	Minor		Inter Info	[352]
Affected excretion pathways
	Increased renal excretion (Unspecific)					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Minor		Inter Info	[328], [329], [330]
D0671		Fludrocortisone	C21H29FO5	31378	Minor		Inter Info	[328], [329], [330]
D0773		Hydrocortisone	C21H30O5	5754	Minor		Inter Info	[328], [329], [330]
D0436		Deflazacort	C25H31NO6	189821	Minor		Inter Info	[328], [329], [330]
D0453		Dexamethasone	C22H29FO5	5743	Minor		Inter Info	[328], [329], [330]
D1041		Methylprednisolone	C22H30O5	6741	Minor		Inter Info	[328], [329], [330]
D1332		Prednisolone	C21H28O5	5755	Minor		Inter Info	[328], [329], [330]
D1334		Prednisone	C21H26O5	5865	Minor		Inter Info	[328], [329], [330]
D1628		Triamcinolone	C21H27FO6	31307	Minor		Inter Info	[328], [329], [330]
D1630		Triamcinolone (ophthalmic)	C21H27FO6	31307	Minor		Inter Info	[328], [329], [330]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[298]
	Additive dopaminergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[112]
	Additive serotonergic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[282]
	Increased risk of hepatotoxicity					Drug Num: 24
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0751		Halothane	C2HBrClF3	3562	Major		Inter Info	[9], [10], [11], [12]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[13], [14], [15]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[21]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[22]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[13], [14], [15]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[73], [74], [75], [16], [31], [76], [77], [78], [79], [80], [81], [82], [83]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[101]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[118], [119]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[16], [31], [124]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[161], [162], [163], [164]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[161], [162], [163], [164]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[180]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[182], [183]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[73], [74], [75], [16], [31], [76], [77], [78], [79], [80], [81], [82], [83]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[31], [199]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[237]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[161], [162], [163], [164]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[16], [31], [273], [274], [275]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[31], [294]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[311]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[73], [74], [75], [16], [31], [76], [77], [78], [79], [80], [81], [82], [83]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[322], [323]
D1400		Rifampicin	C43H58N4O12	135398735	Minor		Inter Info	[348], [349], [350]
D1399		Rifabutin	C46H62N4O11	135398743	Minor		Inter Info	[355], [356], [348], [13], [16], [31], [357], [358], [359], [349], [360], [361], [362], [350]
	Increased risk of nephrotoxicity					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0570		Enflurane	C3H2ClF5O	3226	Moderate		Inter Info	[121], [122], [123]
D0855		Isoflurane	C3H2ClF5O	3763	Moderate		Inter Info	[121], [122], [123]
	Increased risk of peripheral neuropathy					Drug Num: 72
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[84], [85], [86]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[51], [52], [53]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[51], [52], [53]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[51], [52], [53]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[51], [52], [53]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[51], [52], [53]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[51], [52], [53]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[51], [52], [53]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[51], [52], [53]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[51], [52], [53]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[51], [52], [53]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[51], [52], [53]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[51], [52], [53]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[51], [52], [53]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[51], [52], [53]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[51], [52], [53]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[51], [52], [53]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[51], [52], [53]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[51], [52], [53]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[51], [52], [53]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[51], [52], [53]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[51], [52], [53]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[51], [52], [53]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[51], [52], [53]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[51], [52], [53]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[51], [52], [53]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[51], [52], [53]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[51], [52], [53]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[51], [52], [53]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[51], [52], [53]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[51], [52], [53]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[51], [52], [53]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[51], [52], [53]
D1313		Ponatinib	C29H27F3N6O	24826799	Moderate		Inter Info	[51], [52], [53]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[51], [52], [53]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[51], [52], [53]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[51], [52], [53]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[51], [52], [53]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[84], [16], [31], [291]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[51], [52], [53]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[51], [52], [53]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[51], [52], [53]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[51], [52], [53]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[51], [52], [53]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[51], [52], [53]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[51], [52], [53]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[51], [52], [53]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[51], [52], [53]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[51], [52], [53]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[51], [52], [53]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[51], [52], [53]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[51], [52], [53]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[51], [52], [53]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[51], [52], [53]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[51], [52], [53]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[51], [52], [53]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[84], [327]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[313], [31], [314]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 36
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[43], [44], [45]
D0013		Acetohexamide	C15H20N2O4S	1989	Moderate		Inter Info	[43], [44], [45]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[43], [44], [45]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[43], [44], [45]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[43], [44], [45]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[43], [44], [45]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[43], [44], [45]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[43], [44], [45]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[43], [44], [45]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[43], [44], [45]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[43], [44], [45]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[43], [44], [45]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[43], [44], [45]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[43], [44], [45]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[43], [44], [45]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[43], [44], [45]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[43], [44], [45]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[43], [44], [45]
D0807		Insulin aspart (aspart protamine)	C256H381N65O79S6	118984445	Moderate		Inter Info	[43], [44], [45]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[43], [44], [45]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[43], [44], [45]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[43], [44], [45]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[43], [44], [45]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[43], [44], [45]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[43], [44], [45]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[43], [44], [45]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[43], [44], [45]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[43], [44], [45]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[43], [44], [45]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[43], [44], [45]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[43], [44], [45]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[43], [44], [45]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[43], [44], [45]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[43], [44], [45]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[43], [44], [45]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[43], [44], [45]
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[43], [44], [45]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[43], [44], [45]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[43], [44], [45]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[43], [44], [45]
	Antagonize the effect of vaccine/toxoid					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[31], [32], [33]
D1693		Vibrio cholerae CVD 103-HgR strain live antigen (live)	NA	NA	Major		Inter Info	[34]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[264], [265], [266]

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80	Product Information. Elspar (asparaginase). Merck & Co, Inc, West Point, PA.
81	Product Information. Erwinaze (asparaginase Erwinia chrysanthemi). EUSA Pharma, Newtown, PA.
82	Product Information. Oncaspar (pegaspargase). Rhone-Poulenc Rorer, Collegeville, PA.
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142	Product Information. Migranal (dihydroergotamine nasal). Novartis Pharmaceuticals, East Hanover, NJ.
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156	Product Information. Actiq (fentanyl). Abbott Pharmaceutical, Abbott Park, IL.
157	Product Information. Duragesic Transdermal System (fentanyl). Janssen Pharmaceutica, Titusville, NJ.
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162	Product Information. Betaseron (interferon beta-1b). Berlex, Richmond, CA.
163	Product Information. Plegridy (peginterferon beta-1a). Biogen Idec Inc, Cambridge, MA.
164	Product Information. Rebif (interferon beta-1a). Serono Laboratories Inc, Norwell, MA.
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168	Product Information. Onivyde (irinotecan liposomal). Merrimack Pharmaceuticals, Cambridge, MA.
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170	Product Information. Lotronex (alosetron). Glaxo Wellcome, Research Triangle Park, NC.
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179	Product Information. Ayvakit (avapritinib). Blueprint Medicines Corporation, Cambridge, MA.
180	Product Information. Sirturo (bedaquiline). Janssen Pharmaceuticals, Titusville, NJ.
181	Product Information. Bosulif (bosutinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
182	Product Information. Accolate (zafirlukast). Zeneca Pharmaceuticals, Wilmington, DE.
183	Product Information. Adcetris (brentuximab vedotin). Seattle Genetics Inc, Bothell, WA.
184	Product Information. Alunbrig (brigatinib). Ariad Pharmaceuticals Inc, Cambridge, MA.
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195	Product Information. Incivek (telaprevir). Vertex Pharmaceuticals, Cambridge, MA.
196	Product Information. Victrelis (boceprevir). Schering-Plough Corporation, Kenilworth, NJ.
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232	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
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234	Product Information. Zepatier (elbasvir-grazoprevir). Merck &amp Company Inc, Whitehouse Station, NJ.
235	Product Information. Intuniv (guanfacine). Shire US Inc, Florence, KY.
236	Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
237	Product Information. Zydelig (idelalisib). Gilead Sciences, Foster City, CA.
238	Product Information. Indium Oxyquinoline In-111 (indium oxyquinoline In-111). GE Healthcare, Princeton, NJ.
239	Product Information. Nizoral (ketoconazole). Janssen Pharmaceutica, Titusville, NJ.
240	Product Information. Corlanor (ivabradine). Amgen USA, Thousand Oaks, CA.
241	Product Information. Kalydeco (ivacaftor). Vertex Pharmaceuticals, Cambridge, MA.
242	Product Information. Orkambi (ivacaftor-lumacaftor). Vertex Pharmaceuticals, Cambridge, MA.
243	Product Information. Tykerb (lapatinib). Novartis Pharmaceuticals, East Hanover, NJ.
244	Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
245	Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
246	Product Information. Zurampic (lesinurad). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
247	Product Information. Chirocaine (levobupivacaine) Organon, West Orange, NJ.
248	Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
249	Product Information. Caplyta (lumateperone). Intra-Cellular Therapies, Inc., New York, NY.
250	Product Information. Latuda (lurasidone). Sunovion Pharmaceuticals Inc, Marlborough, MA.
251	Product Information. Zepzelca (lurbinectedin). Jazz Pharmaceuticals, Palo Alto, CA.
252	Product Information. Opsumit (macitentan). Actelion Pharmaceuticals US Inc, South San Francisco, CA.
253	Product Information. Selzentry (maraviroc). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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255	Product Information. Rydapt (midostaurin). Novartis Pharmaceuticals, East Hanover, NJ.
256	Product Information. Lynparza (olaparib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
257	Product Information. Isturisa (osilodrostat). Recordati Rare Diseases Inc, Lebanon, NJ.
258	Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
259	Product Information. Osphena (ospemifene). Shionogi USA Inc, Florham Park, NJ.
260	Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
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262	Product Information. Farydak (panobinostat). Novartis Pharmaceuticals, East Hanover, NJ.
263	Product Information. Pemazyre (pemigatinib). Incyte Corporation, Wilmington, DE.
264	Product Information. Prepopik (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
265	MHRA. Medicines and Healthcare Regulatory Agency (general site Reference).
266	Product Information. Clenpiq (citric acid/Mg oxide/Na picosulfate). Ferring Pharmaceuticals Inc, Tarrytown, NY.
267	Product Information. Nuplazid (pimavanserin). Accelis Pharma, East Windsor, NJ.
268	Product Information. Esbriet (pirfenidone). Intermune Inc, Brisbane, CA.
269	Product Information. Varubi (rolapitant). Tesaro Inc., Waltham, MA.
270	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
271	Product Information. Rozerem (ramelteon). Takeda Pharmaceuticals America, Lincolnshire, IL.
272	Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
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276	Product Information. Kisqali (ribociclib). Novartis Pharmaceuticals, East Hanover, NJ.
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278	Product Information. Edurant (rilpivirine). Tibotec Pharmaceuticals, Titusville, NJ.
279	Product Information. Qinlock (ripretinib). Deciphera Pharmaceuticals, Waltham, MA.
280	Product Information. Daliresp (roflumilast). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
281	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
282	Product Information. Xadago (safinamide). US WorldMeds LLC, Louisville , KY.
283	Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
284	Product Information. Koselugo (selumetinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
285	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
286	Product Information. VESIcare (solifenacin). GlaxoSmithKline, Research Triangle Park, NC.
287	Product Information. Odomzo (sonidegib). Novartis Pharmaceuticals, East Hanover, NJ.
288	Product Information. Belsomra (suvorexant). Merck & Company Inc, Whitehouse Station, NJ.
289	Product Information. Hetlioz (tasimelteon). Vanda Pharmaceuticals Inc, Rockville, MD.
290	Product Information. Tazverik (tazemetostat). Epizyme, Inc, Cambridge, MA.
291	Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
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293	Product Information. Detrol (tolterodine). Pharmacia and Upjohn, Kalamazoo, MI.
294	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
295	Product Information. Ubrelvy (ubrogepant). Allergan Inc, Irvine, CA.
296	Product Information. Venclexta (venetoclax). AbbVie US LLC, North Chicago, IL.
297	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
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307	Product Information. Korlym (mifepristone). Corcept Therapeutics Incorporated, Menlo Park, CA.
308	Product Information. Mifeprex (mifepristone) Danco Laboratories, New York, NY.
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316	Product Information. Requip (ropinirole). SmithKline Beecham, Philadelphia, PA.
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319	Product Information. Viagra (sildenafil). Pfizer US Pharmaceuticals, New York, NY.
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339	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
340	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
341	Product Information. Tivicay (dolutegravir). ViiV Healthcare, Research Triangle Park, NC.
342	Product Information. Pifeltro (doravirine). Merck & Company Inc, Whitehouse Station, NJ.
343	Product Information. Kaletra (lopinavir-ritonavir) Abbott Pharmaceutical, Abbott Park, IL.
344	Product Information. Myrbetriq (mirabegron). Astellas Pharma US, Inc, Deerfield, IL.
345	Product Information. Movantik (naloxegol). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
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353	Product Information. ella (ulipristal). Afaxys Inc., Charleston, SC.
354	Product Information. Elidel (pimecrolimus topical). Novartis Pharmaceuticals, East Hanover, NJ.
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360	Product Information. Rifadin (rifampin). Hoechst Marion-Roussel Inc, Kansas City, MO.
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368	Product Information. Naropin (ropivacaine). Astra USA, Westborough, MA.
369	Arlander E, Ekstrom G, Alm C, Carrillo JA, Bielenstein M, Bottiger Y, Bertilsson L, Gustafsson LL "Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors." Clin Pharmacol Ther 64 (1998): 484-91. [PMID: 9834040]
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371	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
372	Wilner KD, Hansen RA, Folger CJ, Geoffroy P "The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid." Br J Clin Pharmacol 49(Suppl 1) (2000): 57S-60S. [PMID: 10771455]
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