Details of Drug-Drug Interaction
| Drug General Information (ID: DDIRP9X3WH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Drug Name | Haloperidol | Drug Info | Isoniazid | Drug Info | |||||
| Drug Type | Small molecule | Small molecule | |||||||
| Therapeutic Class | Antipsychotic Agents | Antitubercular Agents | |||||||
| Structure | |||||||||
| Mechanism of Haloperidol-Isoniazid Interaction (Severity Level: Minor) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph | |||||||||
| Drug Name | Haloperidol | Isoniazid | |||||||
| Mechanism | Haloperidol | Inhibition of hepatic metabolism of haloperidol | |||||||
| Key Mechanism Factor 1 | |||||||||
| Factor Name | Pharmacokinetics | ||||||||
| Factor Description | Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects. | ||||||||
| Mechanism Description |
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| References | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Takeda M, Nishinuma K, Yamashita S, et al "Serum haloperidol levels of schizophrenics receiving treatment for tuberculosis." Clin Neuropharmacol 9 (1986): 386-97. [PMID: 3731135] | ||||||||||||||||||