Drug General Information (ID: DDI4CZPVIH)
Drug Name			Isoniazid		Drug Info		Halothane		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antitubercular Agents				Anesthetics
Structure

Mechanism of Isoniazid-Halothane Interaction (Severity Level: Major)
Increased risk of hepatotoxicity Click to Show/Hide Mechanism Graph
Drug Name		Isoniazid				Halothane
Mechanism		Hepatotoxicity				Hepatotoxicity
Key Mechanism Factor 1
		Factor Name		Hepatotoxicity
		Factor Description		Combination of drugs that can induce hepatotoxicity may increase the risk of liver injury. Symptoms vary depending on the level of exposure and the total extent of liver damage, and may cause few symptoms if the damage is mild, and eventually lead to liver failure in patients with severe damage.
Mechanism Description		Increased risk of hepatotoxicity by the combination of Isoniazid and Halothane

Recommended Action
Management		Until more information is available, it is best to avoid this combination after halothane anesthesia.

References
1	Bartelink AK, Lenders JW, van Herwaarden CL, et al "Fatal hepatitis after treatment with isoniazid and rifampicin in a patient on anticonvulsant therapy." Tubercle 64 (1983): 125-8. [PMID: 6612792]
2	Most JA, Markle GB "A nearly fatal hepatotoxic reaction to rifampin after halothane anesthesia." Am J Surg 127 (1974): 593. [PMID: 4822375]
3	Pessayre D, Bentata M, Degott C, et al. "Isoniazid-rifampin fulminant hepatitis." Gastroenterology 72 (1977): 284-9. [PMID: 830577]
4	Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65. [PMID: 1559307]