Drug General Information (ID: DDISIDG986)
Drug Name			Sucralfate		Drug Info		Isoniazid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Gi Agents				Antitubercular Agents
Structure

Mechanism of Sucralfate-Isoniazid Interaction (Severity Level: Minor)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Sucralfate				Isoniazid
Mechanism		Decrease the absorption of isoniazid				Isoniazid
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Isoniazid caused by Sucralfate

References
1	Hava M, Hurwitz A "The relaxing effect of aluminum and lanthanum on rat and human gastric smooth muscle in vitro." Eur J Pharmacol 156 (1973): 156-61. [PMID: 4715218]
2	Hurwitz A, Schlozman DL "Effects of antacids on gastrointestional absorption of isoniazid in rat and man." Am Rev Respir Dis 109 (1974): 41-7. [PMID: 4588090]