Drug General Information (ID: DDICQ73HD8)
Drug Name			Isoniazid		Drug Info		Kaolin		Drug Info
Drug Type		Small molecule				Natural product
Therapeutic Class		Antitubercular Agents				Herbal Products
Structure

Mechanism of Isoniazid-Kaolin Interaction (Severity Level: Minor)
Altered absorption (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Isoniazid				Kaolin
Mechanism		Isoniazid				Decrease the absorption of isoniazid
Key Mechanism Factor 1
		Factor Name		Pharmacokinetic
		Factor Description		Alters the absorption of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Altered absorption of Isoniazid caused by Kaolin

References
1	Hava M, Hurwitz A "The relaxing effect of aluminum and lanthanum on rat and human gastric smooth muscle in vitro." Eur J Pharmacol 156 (1973): 156-61. [PMID: 4715218]
2	Hurwitz A, Schlozman DL "Effects of antacids on gastrointestional absorption of isoniazid in rat and man." Am Rev Respir Dis 109 (1974): 41-7. [PMID: 4588090]