Drug General Information (ID: DDID8IEB2C)
Drug Name			Indinavir		Drug Info		Isoniazid		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anti-Hiv Agents				Antitubercular Agents
Structure

Mechanism of Indinavir-Isoniazid Interaction (Severity Level: Minor)
Competitive inhibition of metabolic enzyme Click to Show/Hide Mechanism Graph
Drug Name		Indinavir				Isoniazid
Mechanism		Competitive inhibition of isoniazid metabolism				Isoniazid
Key Mechanism Factor 1
		Factor Name		Enzyme
		Factor Description		Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
Mechanism Description		Increased plasma concentrations of Isoniazid and Indinavir due to competitive inhibition of the same metabolic pathway

References
1	Product Information. Crixivan (indinavir). Merck & Co, Inc, West Point, PA.