Drug General Information (ID: DDIMJS30N4)
  Drug Name Isoniazid Drug Info Thiothixene Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antitubercular Agents Antipsychotic Agents
  Structure

 Mechanism of Isoniazid-Thiothixene Interaction (Severity Level: Minor)
     Decreased metabolism (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Isoniazid Thiothixene
      Mechanism Inhibit the hepatic metabolism of thioxanthenes Thioxanthenes
      Key Mechanism Factor 1
Factor Name Pharmacokinetics
Factor Description Alters the metabolism of the drug, leading to changes in the plasma concentration of the drug and affecting the pharmacological effects.
      Mechanism Description
  • Decreased metabolism of Thiothixene caused by Isoniazid 

References
1 Ereshefsky L, Saklad SR, Watanabe MD, Davis CM, Jann MW "Thiothixene pharmacokinetic interactions: a study of hepatic enzyme inducers, clearance inhibitors, and demographic variables." J Clin Psychopharmacol 11 (1991): 296-301. [PMID: 1765572]