Details of Drug

Drug General Information (ID: D0030)
Drug Name	Aldesleukin
Drug Type	Interferons
Drug Synonymous	Proleukin (TN) Click to Show/Hide
Disease Class	2C90: Renal cell carcinoma; 2B33: Malignant haematopoietic neoplasm
Therapeutic Class	Antineoplastics
External Link
External Link	TTD ID	D05PUD

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM006 Altered intestinal mucosa BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM043 Additive immunosuppressive effects BM044 Additive myelosuppressive effects BM047 Additive thrombogenic effects BM048 Increased risk of angioedema/anaphylactoid reactions BM055 Increased risk of hepatotoxicity BM069 Increased risk of lowers seizure threshold BM072 Increased risk of nephrotoxicity BM075 Increased risk of photosensitivity reactions BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Aldesleukin
Affected gastrointestinal absorption
	Altered intestinal mucosa					Drug Num: 15
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0340		Cinoxacin	C12H10N2O5	2762	Minor		Inter Info	[184]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Minor		Inter Info	[184]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Minor		Inter Info	[184]
D0573		Enoxacin	C15H17FN4O3	3229	Minor		Inter Info	[184]
D0712		Gatifloxacin	C19H22FN3O4	5379	Minor		Inter Info	[184]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Minor		Inter Info	[184]
D0740		Grepafloxacin	C19H22FN3O3	72474	Minor		Inter Info	[184]
D0919		Levofloxacin	C18H20FN3O4	149096	Minor		Inter Info	[184]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Minor		Inter Info	[184]
D1092		Moxifloxacin	C21H24FN3O4	152946	Minor		Inter Info	[184]
D1102		Nalidixic acid	C12H12N2O3	4421	Minor		Inter Info	[184]
D1155		Norfloxacin	C16H18FN3O3	4539	Minor		Inter Info	[184]
D1165		Ofloxacin	C18H20FN3O4	4583	Minor		Inter Info	[184]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Minor		Inter Info	[184]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Minor		Inter Info	[184]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[127]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[77]
D0629		Everolimus	C53H83NO14	6442177	Moderate		Inter Info	[111], [112]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[77]
D0962		Lurbinectedin	C41H44N4O10S	57327016	Moderate		Inter Info	[149]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[77]
D1143		Nitisinone	C14H10F3NO5	115355	Moderate		Inter Info	[15], [10], [11]
D1324		Pralsetinib	C27H32FN9O2	129073603	Moderate		Inter Info	[168]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[77]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[77]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 136
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[73], [38], [11]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[74], [11], [38]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[73], [38], [11]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[73], [38], [11]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[73], [38], [11]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[73], [38], [11]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[73], [38], [11]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[74], [38], [11]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[97]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[73], [38], [11]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[73], [38], [11]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[73], [38], [11]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[73], [38], [11]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[73], [38], [11]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[73], [38], [11]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[73], [38], [11]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[73], [38], [11]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[73], [38], [11]
D0311		Chloral hydrate	C2H3Cl3O2	2707	Moderate		Inter Info	[73], [38], [11]
D0316		Chlorcyclizine	C18H21ClN2	2710	Moderate		Inter Info	[73], [38], [11]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[73], [38], [11]
D0318		Chlormezanone	C11H12ClNO3S	2717	Moderate		Inter Info	[73], [38], [11]
D0322		Chlorphenesin	C9H11ClO3	7697	Moderate		Inter Info	[73], [38], [11]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[73], [38], [11]
D0327		Chlorzoxazone	C7H4ClNO2	2733	Moderate		Inter Info	[73], [38], [11]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[73], [38], [11]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[73], [38], [11]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[73], [38], [11]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[73], [38], [11]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[74], [11], [38]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[73], [38], [11]
D0397		Cyclizine	C18H22N2	6726	Moderate		Inter Info	[73], [38], [11]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[73], [38], [11]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[73], [38], [11]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[73], [38], [11]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[73], [38], [11]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[74], [11], [38]
D0470		Dezocine	C16H23NO	3033053	Moderate		Inter Info	[73], [38], [11]
D0471		Diamorphine	C21H23NO5	5462328	Moderate		Inter Info	[74], [11], [38]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[73], [38], [11]
D0475		Dichloralphenazone	C15H18Cl6N2O5	10188	Moderate		Inter Info	[74], [11], [38]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[74], [11], [38]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[73], [38], [11]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[73], [38], [11]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[73], [38], [11]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[73], [38], [11]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[73], [38], [11]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[73], [38], [11]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[73], [38], [11]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[73], [38], [11]
D0604		Estazolam	C16H11ClN4	3261	Moderate		Inter Info	[73], [38], [11]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[73], [38], [11]
D0618		Ethchlorvynol	C7H9ClO	5281077	Moderate		Inter Info	[73], [38], [11]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[73], [38], [11]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[73], [38], [11]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[73], [38], [11]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[73], [38], [11]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[73], [38], [11]
D0748		Halazepam	C17H12ClF3N2O	31640	Moderate		Inter Info	[73], [38], [11]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[73], [38], [11]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[73], [38], [11]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[73], [38], [11]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[73], [38], [11]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[73], [38], [11]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[145]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[73], [38], [11]
D0909		Levacetylmethadol	C23H31NO2	15130	Moderate		Inter Info	[74], [11], [38]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[73], [38], [11]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[73], [38], [11]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[73], [38], [11]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[73], [38], [11]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[73], [38], [11]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[73], [38], [11]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[74], [38], [11]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[73], [38], [11]
D1014		Metaxalone	C12H15NO3	15459	Moderate		Inter Info	[73], [38], [11]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[73], [38], [11]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[73], [38], [11]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[73], [38], [11]
D1024		Methohexital	C14H18N2O3	9034	Moderate		Inter Info	[73], [38], [11]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[73], [38], [11]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[74], [11], [38]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[73], [38], [11]
D1066		Milnacipran	C15H22N2O	65833	Moderate		Inter Info	[73], [38], [11]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[73], [38], [11]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[73], [38], [11]
D1090		Morphine (liposomal)	C17H19NO3	5288826	Moderate		Inter Info	[74], [11], [38]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[73], [38], [11]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[73], [38], [11]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[73], [38], [11]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[73], [38], [11]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[73], [38], [11]
D1183		Opium	NA	NA	Moderate		Inter Info	[73], [38], [11]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[73], [38], [11]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[73], [38], [11]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[73], [38], [11]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[73], [38], [11]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[73], [38], [11]
D1224		Paraldehyde	C6H12O3	31264	Moderate		Inter Info	[73], [38], [11]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[73], [38], [11]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[73], [38], [11]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[73], [38], [11]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[73], [38], [11]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[73], [38], [11]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[73], [38], [11]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[73], [38], [11]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[73], [38], [11]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[73], [38], [11]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[73], [38], [11]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[73], [38], [11]
D1367		Quazepam	C17H11ClF4N2S	4999	Moderate		Inter Info	[73], [38], [11]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[73], [38], [11]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[73], [38], [11]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[73], [38], [11]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[73], [38], [11]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[73], [38], [11]
D1461		Sertraline	C17H17Cl2N	68617	Moderate		Inter Info	[73], [38], [11]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[73], [38], [11]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[73], [38], [11]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[73], [38], [11]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[73], [38], [11]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[73], [38], [11]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[73], [38], [11]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[73], [38], [11]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[73], [38], [11]
D1573		Thiopental	C11H18N2O2S	3000715	Moderate		Inter Info	[73], [38], [11]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[73], [38], [11]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[73], [38], [11]
D1624		Trazodone	C19H22ClN5O	5533	Moderate		Inter Info	[73], [38], [11]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[73], [38], [11]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[73], [38], [11]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[73], [38], [11]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[73], [38], [11]
D1689		Venlafaxine	C17H27NO2	5656	Moderate		Inter Info	[73], [38], [11]
D1696		Vilazodone	C26H27N5O2	6918314	Moderate		Inter Info	[73], [38], [11]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[73], [38], [11]
	Additive hypotensive effects					Drug Num: 93
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[65]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[38]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[38]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[38]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[38]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[38]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[38]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[38]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[38]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[38]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[38]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[38]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[38]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[38]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[38]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[38]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[38]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[38]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[38]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[38]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[38]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[38]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[38]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[38]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[38]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[38]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[38]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[38]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[38]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[38]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[38]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[38]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[38]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[38]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[38]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[38]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[38]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[38]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[38]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[38]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[38]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[38]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[38]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[38]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[38]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[38]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[38]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[151]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[38]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[38]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[38]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[38]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[38]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[38]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[38]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[38]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[38]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[38]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[38]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[38]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[38]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[38]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[38]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[38]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[38]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[38]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[38]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[38]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[38]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[38]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[38]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[38]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[38]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[38]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[38]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[38]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[38]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[38]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[132], [133], [134], [135], [136], [137], [138], [139], [140], [141], [142], [143], [144]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[38]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[38]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[38]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[38]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[38]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[38]
	Additive immunosuppressive effects					Drug Num: 78
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[10], [11], [12]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[11], [31]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[35]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[42]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[10], [45]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[66]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[69]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[46], [70], [71]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[72]
D0136		Azathioprine	C9H7N7O2S	2265	Moderate		Inter Info	[10], [11]
D0157		Bendamustine	C16H21Cl2N3O2	65628	Moderate		Inter Info	[11], [75], [92]
D0190		Bleomycin	C55H84N17O21S3+	5360373	Moderate		Inter Info	[11], [75], [92]
D0223		Busulfan	C6H14O6S2	2478	Moderate		Inter Info	[11], [75], [92]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[98], [99], [100]
D0249		Capecitabine	C15H22FN3O6	60953	Moderate		Inter Info	[11], [75], [92]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[11], [75], [92]
D0264		Carmustine	C5H9Cl2N3O2	2578	Moderate		Inter Info	[11], [75], [92]
D0312		Chlorambucil	C14H19Cl2NO2	2708	Moderate		Inter Info	[11], [75], [92]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [104]
D0314		Chloramphenicol (ophthalmic)	C11H12Cl2N2O5	5959	Moderate		Inter Info	[10], [11], [104]
D0400		Cyclophosphamide	C7H15Cl2N2O2P	2907	Moderate		Inter Info	[11], [75], [92]
D0404		Cytarabine	C9H13N3O5	6253	Moderate		Inter Info	[11], [75], [92]
D0405		Cytarabine (liposomal)	C9H13N3O5	6253	Moderate		Inter Info	[11], [75], [92]
D0410		Dactinomycin	C62H86N12O16	457193	Moderate		Inter Info	[11], [75], [92]
D0429		Daunorubicin	C27H29NO10	30323	Moderate		Inter Info	[11], [75], [92]
D0430		Daunorubicin (liposomal)	C27H29NO10	30323	Moderate		Inter Info	[11], [75], [92]
D0431		Decitabine	C8H12N4O4	451668	Moderate		Inter Info	[11], [75], [92]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[106]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[107]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[11], [75], [92]
D0528		Doxorubicin	C27H29NO11	31703	Moderate		Inter Info	[11], [75], [92]
D0529		Doxorubicin (liposomal)	C27H29NO11	31703	Moderate		Inter Info	[11], [75], [92]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[108]
D0584		Epirubicin	C27H29NO11	41867	Moderate		Inter Info	[11], [75], [92]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[11], [75], [92]
D0666		Floxuridine	C9H11FN2O5	5790	Moderate		Inter Info	[11], [75], [92]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[11], [75], [92]
D0675		Fluorouracil	C4H3FN2O2	3385	Moderate		Inter Info	[11], [75], [92]
D0714		Gemcitabine	C9H11F2N3O4	60750	Moderate		Inter Info	[11], [75], [92]
D0780		Hydroxyurea	CH4N2O2	3657	Moderate		Inter Info	[11], [75], [92]
D0788		Idarubicin	C26H27NO9	42890	Moderate		Inter Info	[11], [75], [92]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[11], [75], [92]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[11], [75], [92]
D0851		Isatuximab	NA	NA	Moderate		Inter Info	[11], [75], [92]
D0945		Lomustine	C9H16ClN3O2	3950	Moderate		Inter Info	[11], [75], [92]
D0986		Mechlorethamine	C5H11Cl2N	4033	Moderate		Inter Info	[11], [75], [92]
D0996		Melphalan	C13H18Cl2N2O2	460612	Moderate		Inter Info	[11], [75], [92]
D1007		Mercaptopurine	C5H4N4S	667490	Moderate		Inter Info	[11], [75], [92]
D1077		Mitomycin	C15H18N4O5	5746	Moderate		Inter Info	[11], [75], [92]
D1079		Mitoxantrone	C22H28N4O6	4212	Moderate		Inter Info	[11], [75], [92]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[107]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[11], [75], [92]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[11], [75], [92]
D1140		Niraparib	C19H20N4O	24958200	Moderate		Inter Info	[154]
D1167		Olaparib	C24H23FN4O3	23725625	Moderate		Inter Info	[11], [155]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[156]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[11], [75], [92]
D1241		Pemetrexed	C20H21N5O6	135410875	Moderate		Inter Info	[11], [75], [92]
D1250		Pentostatin	C11H16N4O4	439693	Moderate		Inter Info	[11], [75], [92]
D1375		Radium Ra 223 dichloride	NA	NA	Moderate		Inter Info	[169]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[98], [99], [100]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[11], [173]
D1434		Ruxolitinib	C17H18N6	25126798	Moderate		Inter Info	[11], [75], [92]
D1508		Streptozocin	C8H15N3O7	29327	Moderate		Inter Info	[11], [75], [92]
D1509		Strontium chloride Sr-89	Cl2Sr	5388879	Moderate		Inter Info	[10], [11], [174]
D1548		Temozolomide	C6H6N6O2	5394	Moderate		Inter Info	[11], [75], [92]
D1575		Thiotepa	C6H12N3PS	5453	Moderate		Inter Info	[11], [75], [92]
D1610		Topotecan	C23H23N3O5	60700	Moderate		Inter Info	[177]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[179]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[11], [75], [92]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[10], [11], [180]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[98], [99], [100]
D1855		Palifermin	NA	NA	Moderate		Inter Info	[181]
	Additive myelosuppressive effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0370		Clozapine	C18H19ClN4	135398737	Major		Inter Info	[11], [32], [30]
D0433		Deferiprone	C7H9NO2	2972	Major		Inter Info	[10], [33], [34]
D1443		Samarium (153Sm) lexidronam	Sm	23951	Major		Inter Info	[44]
D0710		Ganciclovir	C9H13N5O4	135398740	Moderate		Inter Info	[10], [11], [116], [117]
D1676		Valganciclovir	C14H22N6O5	135413535	Moderate		Inter Info	[10], [11], [116], [117]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[49], [50], [51], [52], [53], [54], [55], [56], [57], [58], [59], [60], [61], [62], [63], [64]
	Increased risk of angioedema/anaphylactoid reactions					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Major		Inter Info	[11], [29], [30]
D0823		Interferon alfacon-1	NA	NA	Major		Inter Info	[11], [29], [30]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Major		Inter Info	[11], [29], [30]
D0824		Interferon alfa-n1	NA	NA	Major		Inter Info	[11], [29], [30]
D0825		Interferon alfa-n3	NA	NA	Major		Inter Info	[11], [29], [30]
	Increased risk of hepatotoxicity					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[39]
D0944		Lomitapide	C39H37F6N3O2	9853053	Major		Inter Info	[40]
D1073		Mipomersen	C230H324N67O122P19S19	118984467	Major		Inter Info	[41]
D1258		Pexidartinib	C20H15ClF3N5	25151352	Major		Inter Info	[43]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[39]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[80], [81], [82], [10], [11], [83], [84], [85], [86], [87], [88], [89], [90]
D0149		Bedaquiline	C32H31BrN2O2	5388906	Moderate		Inter Info	[91]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[96]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[80], [81], [82], [10], [11], [83], [84], [85], [86], [87], [88], [89], [90]
D0357		Clofarabine	C10H11ClFN5O3	119182	Moderate		Inter Info	[105]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[109], [110]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[126]
D0826		Interferon beta-1a	NA	NA	Moderate		Inter Info	[128], [129], [130], [131]
D0827		Interferon beta-1b	NA	NA	Moderate		Inter Info	[128], [129], [130], [131]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[11], [152]
D1106		Naltrexone	C20H23NO4	5360515	Moderate		Inter Info	[153]
D1234		Pegaspargase	C14H19NO	436058	Moderate		Inter Info	[80], [81], [82], [10], [11], [83], [84], [85], [86], [87], [88], [89], [90]
D1239		Peginterferon beta-1a	NA	NA	Moderate		Inter Info	[128], [129], [130], [131]
D1389		Remdesivir	C27H35N6O8P	121304016	Moderate		Inter Info	[10], [11], [170], [171], [172]
D1589		Tioguanine	C5H5N5S	2723601	Moderate		Inter Info	[175], [176]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[11], [178]
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[80], [81], [82], [10], [11], [83], [84], [85], [86], [87], [88], [89], [90]
	Increased risk of lowers seizure threshold					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27]
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[37], [38]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[37], [38]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[67], [26], [25], [68]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[75], [76]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[10], [11]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[146], [147], [148]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[164], [165], [11]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[164], [165], [11]
	Increased risk of nephrotoxicity					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0335		Cidofovir	C8H14N3O6P	60613	Major		Inter Info	[28]
D0805		Inotersen	C230H318N69O121P19S19	121492004	Major		Inter Info	[11], [36]
	Increased risk of photosensitivity reactions					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[166], [11], [167]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0344		Cisplatin	Cl2H6N2Pt	5702198	Major		Inter Info	[11], [29], [30]
D0407		Dacarbazine	C6H10N6O	135398738	Major		Inter Info	[11], [29], [30]
D1697		Vinblastine	C46H58N4O9	13342	Major		Inter Info	[11], [29], [30]
Pharmacodynamic antagonistic effects
	Antagonize the effect of vaccine/toxoid					Drug Num: 23
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[7], [8], [9]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[7], [8], [9]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[46], [10], [47]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[48]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[7], [8], [9]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[7], [8], [9]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[7], [8], [9]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[46], [78], [79]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[46], [78], [79]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[46], [78], [79]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[46], [78], [79]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[46], [78], [79]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[46], [78], [79]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[46], [78], [79]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[150]
D0999		Meningococcal polysaccharide vaccine group C	NA	NA	Moderate		Inter Info	[46], [78], [79]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[157], [46], [10], [158], [159], [160], [78], [161], [162], [163], [79]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[46], [78], [79]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[46], [78], [79]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[46], [78], [79]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[93], [94], [95]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[93], [94], [95]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[101], [102], [103]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[101], [102], [103]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[101], [102], [103]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[101], [102], [103]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 13
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[38]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[38]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[38]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[38]
D0659		Filgrastim	NA	NA	Moderate		Inter Info	[113], [114], [115]
D0773		Hydrocortisone	C21H30O5	5754	Moderate		Inter Info	[38]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[38]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[38]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[38]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[38]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[38]
D1235		Pegfilgrastim	C27H46N4O19	70683024	Moderate		Inter Info	[182], [183]
D1446		Sargramostim	NA	NA	Moderate		Inter Info	[113], [114], [115]

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111	Product Information. Afinitor (everolimus). Novartis Pharmaceuticals, East Hanover, NJ.
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113	Product Information. Granix (tbo-filgrastim). Teva Pharmaceuticals USA, North Wales, PA.
114	Product Information. Leukine (sargramostim). Immunex Corporation, Seattle, WA.
115	Product Information. Stemgen (ancestim) Amgen, Thousand Oaks, CA.
116	Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
117	Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
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153	Product Information. ReVia (naltrexone). DuPont Pharmaceuticals, Wilmington, DE.
154	Product Information. Zejula (niraparib). Tesaro Inc., Waltham, MA.
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156	Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
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158	Product Information. Biothrax (anthrax vaccine adsorbed). Emergent BioSolutions Inc., Lansing, MI.
159	Product Information. Fluzone Influenza Vaccine (influenza virus vaccine). Connaught, Swiftwater, PA.
160	Product Information. Havrix (hepatitis A vaccine). SmithKline Beecham, Philadelphia, PA.
161	Product Information. Influenza Virus Vaccine, H5N1, Inactivated (influenza virus vaccine, H5N1, inactivated). GlaxoSmithKline, Research Triangle Park, NC.
162	Product Information. Omnihib (haemophilus b conjugate vaccine). SmithKline Beecham, Philadelphia, PA.
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164	Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
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166	Blakely KM, Drucker AM, Rosen CF "Drug-induced photosensitivity-an update: Culprit drugs, prevention and management." Drug Saf 42 (2019): 827-47. [PMID: 30888626]
167	Product Information. Photofrin (porfimer). Sanofi Winthrop Pharmaceuticals, New York, NY.
168	Product Information. Gavreto (pralsetinib). Blueprint Medicines Corporation, Cambridge, MA.
169	Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
170	European Medicines Agency "Summary on compassionate use. Remdesivir Gilead.".
171	Gilead Sciences, Inc "About Remdesivir.".
172	US Food and Drug Administration "Fact sheet for health care providers emergency use authorization (EUA) of remdesivir (GS-5734TM)".
173	Product Information. Daxas (roflumilast). Nycomed Inc, Princeton, NJ.
174	Multum Information Services, Inc. Expert Review Panel.
175	Product Information. Aubagio (teriflunomide). Genzyme Corporation, Cambridge, MA.
176	Product Information. Tabloid (thioguanine). Prasco Laboratories, Cincinnati, OH.
177	Product Information. Hycamtin (topotecan). SmithKline Beecham, Philadelphia, PA.
178	Product Information. Yondelis (trabectedin). Janssen Pharmaceuticals, Titusville, NJ.
179	Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
180	Product Information. Retrovir (zidovudine). Glaxo Wellcome, Research Triangle Park, NC.
181	Product Information. Kepivance (palifermin). Shire US Inc, Florence, KY.
182	Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA.
183	Product Information. Neulasta (pegfilgrastim). Amgen, Thousand Oaks, CA.
184	Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42. [PMID: 2373666]

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