Drug General Information (ID: DDIJWIE089)
Drug Name			Aldesleukin		Drug Info		Dacarbazine		Drug Info
Drug Type		Interferons				Small molecule
Therapeutic Class		Antineoplastics				Antineoplastics

Mechanism of Aldesleukin-Dacarbazine Interaction (Severity Level: Major)
Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Aldesleukin				Dacarbazine
Mechanism		Aldesleukin				Increases risk of fatal tumor lysis syndrome in combination with Aldesleukin
Key Mechanism Factor 1
		Factor Name		Adverse reactions
		Factor Description		An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
Mechanism Description		Increased risk of adverse reactions by the combination of Aldesleukin and Dacarbazine

Recommended Action
Management		Concomitant use is not recommended.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
3	Canadian Pharmacists Association "e-CPS."