Drug General Information (ID: DDIQGHRETU)
  Drug Name Interferon alfa-2a, Recombinant Drug Info Aldesleukin Drug Info
  Drug Type Interferons Interferons
  Therapeutic Class Interferons Antineoplastics

 Mechanism of Interferon alfa-2a, Recombinant-Aldesleukin Interaction (Severity Level: Major)
     Increased risk of angioedema/anaphylactoid reactions Click to Show/Hide Mechanism Graph
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      Drug Name Interferon alfa-2a, Recombinant Aldesleukin
      Mechanism 1 Anaphylactoid reactions Anaphylactoid reactions
      Key Mechanism Factor 1
Factor Name Angioedema/anaphylactoid reactions
Factor Description Anaphylactoid reaction is a condition in which symptoms similar to an allergic reaction occur, but no immune sensitization is detected. Most commonly, the syndrome begins with skin involvement, usually pruritus, flushing, urticaria, or angioedema. Angioedema is a reaction to a trigger that causes swelling of the tissue below the inner layer of the skin, called the dermis or submucosa, and the swelling can occur on the face, throat, or around the genitals.
      Mechanism Description
  • Increased risk of angioedema by the combination of Interferon alfa-2a, Recombinant and Aldesleukin 
     Increased risk of other adverse reactions (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Interferon alfa-2a, Recombinant Aldesleukin
      Mechanism 2 Rhabdomyolysis Rhabdomyolysis
      Key Mechanism Factor 2
Factor Name Adverse reactions
Factor Description An adverse reaction is an unexpected negative reaction to a medication or treatment that happens even when it's used correctly.
      Mechanism Description
  • Increased risk of adverse reactions by the combination of Interferon alfa-2a, Recombinant and Aldesleukin 

Recommended Action
      Management Caution and close clinical and laboratory monitoring for signs and symptoms of toxicity and hypersensitivity reactions is advisable.

References
1 Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2 Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA."
3 Canadian Pharmacists Association "e-CPS."