Drug General Information (ID: DDI3OCFI7A)
Drug Name			Aldesleukin		Drug Info		Prednisolone		Drug Info
Drug Type		Interferons				Small molecule
Therapeutic Class		Antineoplastics				Antineoplastics

Mechanism of Aldesleukin-Prednisolone Interaction (Severity Level: Moderate)
Attenuated pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Aldesleukin				Prednisolone
Mechanism		Aldesleukin				Reduce the antitumor effect of aldesleukin
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Reduced pharmacological effects leading to insufficient efficacy and/or treatment failure.
Mechanism Description		Attenuated pharmacological effects of  Aldesleukin when combined with Prednisolone

Recommended Action
Management		Although glucocorticoids can attenuate aldesleukin-induced side effects including fever, renal insufficiency, hyperbilirubinemia, confusion and dyspnea, concomitant administration of these agents with aldesleukin should generally be avoided. However, patients who develop life-threatening signs or symptoms may be treated with dexamethasone until toxicity resolves to an acceptable level.

References
1	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.