Details of Drug

Drug General Information (ID: D1332)
Drug Name	Prednisolone
Drug Type	Small molecule
Drug Synonymous	Nanocort; Prednisolone (injectable liposome formulation, rheumatoid arthritis); Prednisolone (injectable liposome formulation, rheumatoid arthritis), Enceladus; Prednisolone (injectable liposome formulation, rheumatoid arthritis), Galapagos Click to Show/Hide
Disease Class	2A00-2F9Z: Solid tumour/cancer; 8A40: Multiple sclerosis
Therapeutic Class	Antineoplastics
Structure
Structure	3D Structure		2D Structure
Formula	C21H28O5
InChI	1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChIKey	OIGNJSKKLXVSLS-VWUMJDOOSA-N
Canonical SMILES	CC12CC(C3C(C1CCC2(C(=O)CO)O)CCC4=CC(=O)C=CC34C)O
External Link
	Pubchem ID	5755
	CAS Number	50-24-8
	CHEBI ID	8378
	TTD ID	D0D1SG
	INTEDE ID	DR1332
	VARIDT ID	DR00428

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM005 Affected excretion pathways AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM003 Complex formation BM005 Altered gastric pH BM010 Transporter inhibition BM011 Transporter induction BM014 Interference of cell/tissue uptake BM015 Increase globulin concentration BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM024 Competitive inhibition of metabolic enzyme BM026 Increased metabolism (Unspecific) BM031 Increased renal excretion (Unspecific) BM043 Additive immunosuppressive effects BM045 Additive neuromuscular blocking effects BM047 Additive thrombogenic effects BM050 Increased risk of bleeding BM054 Increased risk of GI mucosal injury/bleeding risk BM056 Increased risk of hyperammonemia BM057 Increased risk of hyperglycemia BM065 Increased risk of hypokalemia BM067 Increased risk of hyponatremia BM069 Increased risk of lowers seizure threshold BM080 Increased risk of tendinitis/tendon rupture BM083 Potentiated the pharmacological effects (Unspecific) BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM091 Antagonize the effect of cholinergic agents BM092 Antagonize the effect of corticosteroids BM100 Antagonize the effect of vaccine/toxoid BM105 Antagonize the effect of probiotics BM106 Diminish the response to diagnostic skin test antigens BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific) BM110 Antagonize the effects of immunosuppressants
Relation Graph

Full list of drugs interacting with Prednisolone
Affected gastrointestinal absorption
	Complex formation					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0382		Colestipol	C11H28ClN5O	62816	Moderate		Inter Info	[128], [129], [130], [131], [132]
D0329		Cholestyramine	C27H47ClN2	137699107	Moderate		Inter Info	[128], [129], [130], [131], [132]
D0381		Colesevelam	C31H67Cl3N4O	160051	Moderate		Inter Info	[128], [129], [130], [131], [132]
	Altered gastric pH					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Minor		Inter Info	[328], [329], [330]
D0236		Calcium carbonate	CCaO3	10112	Minor		Inter Info	[328], [329], [330]
D0967		Magaldrate	AlHMgO5S+2	3086011	Minor		Inter Info	[328], [329], [330]
D0974		Magnesium oxide	MgO	14792	Minor		Inter Info	[328], [329], [330]
D1480		Sodium bicarbonate	CHNaO3	516892	Minor		Inter Info	[328], [329], [330]
Affected cellular transport
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0708		Gallium chloride Ga-67	Cl3Ga	73415785	Moderate		Inter Info	[262]
D1817		Indium In-111 oxyquinoline	C27H18InN3O3	16685037	Moderate		Inter Info	[265]
	Increase globulin concentration					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0387		Conjugated estrogens	C18H21NaO5S	45357473	Moderate		Inter Info	[133], [134], [135]
D0388		Conjugated estrogens (topical)	C18H21NaO5S	45357473	Moderate		Inter Info	[133], [134], [135]
D0487		Diethylstilbestrol	C18H20O2	448537	Moderate		Inter Info	[133], [134], [135]
D0606		Estradiol	C18H24O2	5757	Moderate		Inter Info	[133], [134], [135]
D0607		Estradiol (topical)	C18H24O2	5757	Moderate		Inter Info	[133], [134], [135]
D0609		Estrone	C18H22O2	5870	Moderate		Inter Info	[133], [134], [135]
D0484		Dienestrol (topical)	C18H18O2	667476	Moderate		Inter Info	[133], [134], [135]
D0605		Esterified estrogens	NA	NA	Moderate		Inter Info	[133], [134], [135]
D0608		Estramustine	C23H31Cl2NO3	259331	Moderate		Inter Info	[133], [134], [135]
D0610		Estrone sulfate	C18H22O5S	3001028	Moderate		Inter Info	[133], [134], [135]
D0611		Estrone sulfate (topical)	C18H22O5S	3001028	Moderate		Inter Info	[133], [134], [135]
D0619		Ethinylestradiol	C20H24O2	5991	Moderate		Inter Info	[133], [134], [135]
D1011		Mestranol	C21H26O2	6291	Moderate		Inter Info	[133], [134], [135]
D1370		Quinestrol	C25H32O2	9046	Moderate		Inter Info	[133], [134], [135]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 46
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0100		Aprepitant	C23H21F7N4O3	135413536	Moderate		Inter Info	[96], [97]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0667		Fluconazole	C13H12F2N6O	3365	Moderate		Inter Info	[176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193]
D0687		Fluvoxamine	C15H21F3N2O2	5324346	Moderate		Inter Info	[194], [195]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[196]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1119		Nelfinavir	C32H45N3O4S	64143	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0002		Abametapir (topical)	C12H12N2	15664	Moderate		Inter Info	[212]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0171		Berotralstat	C30H26F4N6O	137528262	Moderate		Inter Info	[233]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0375		Cobicistat	C40H53N7O5S2	25151504	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0413		Dalfopristin	C34H50N4O9S	6323289	Moderate		Inter Info	[246]
D0426		Darunavir	C27H37N3O7S	213039	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0428		Dasatinib	C22H26ClN7O2S	3062316	Moderate		Inter Info	[247]
D0543		Duvelisib	C22H17ClN6O	50905713	Moderate		Inter Info	[255]
D0638		Fedratinib	C27H36N6O3S	16722836	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0693		Fosaprepitant	C23H22F7N4O6P	135413538	Moderate		Inter Info	[96], [97]
D0699		Fostamatinib	C23H26FN6O9P	11671467	Moderate		Inter Info	[261]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0852		Isavuconazonium	C35H35F2N8O5S+	6918606	Moderate		Inter Info	[14], [266]
D0867		Itraconazole	C35H38Cl2N8O4	55283	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[270]
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D0896		Larotrectinib	C21H22F2N6O2	46188928	Moderate		Inter Info	[20], [14], [271]
D0899		Lefamulin	C28H45NO5S	25185057	Moderate		Inter Info	[272]
D0906		Letermovir	C29H28F4N4O4	45138674	Moderate		Inter Info	[273]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[275]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1398		Ribociclib	C23H30N8O	44631912	Moderate		Inter Info	[285], [286], [287], [288], [289], [290], [291], [292], [293]
D1432		Rucaparib	C19H18FN3O	9931954	Moderate		Inter Info	[301]
D1444		Saquinavir	C38H50N6O5	441243	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1459		Selpercatinib	C29H31N7O3	134436906	Moderate		Inter Info	[14], [303]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[308]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1709		Voxelotor	C19H19N3O3	71602803	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[140], [141], [142], [143], [144], [145], [146], [147], [148], [149], [150], [151], [152], [153], [154], [155], [156], [157], [158], [159], [160], [161], [162], [163], [164], [165], [166], [167], [168]
	CYP450 enzyme induction					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[14], [101], [102]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[103]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[104], [105], [106], [14], [107], [108], [109], [110], [111], [112]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[104], [105], [106], [14], [107], [108], [109], [110], [111], [112]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[113], [114], [115], [116], [117]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[170]
D0621		Ethotoin	C11H12N2O2	3292	Moderate		Inter Info	[171], [172], [173], [174], [111], [175]
D1003		Mephenytoin	C12H14N2O2	4060	Moderate		Inter Info	[171], [172], [173], [174], [111], [175]
D1021		Methimazole	C4H6N2S	1349907	Moderate		Inter Info	[20], [14], [201]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[106], [110], [111]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[20], [14], [205], [206]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[209], [210], [211]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[104], [105], [106], [14], [107], [108], [109], [110], [111], [112]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[171], [172], [173], [174], [111], [175]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[104], [105], [106], [14], [107], [108], [109], [110], [111], [112]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[14], [225]
D0181		Bictegravir	C21H18F3N3O5	90311989	Moderate		Inter Info	[14], [234], [235]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[242]
D0406		Dabrafenib	C23H20F3N5O2S2	44462760	Moderate		Inter Info	[14], [245]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[256], [20], [14], [257]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[258]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[171], [172], [173], [174], [111], [175]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[274]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[104], [105], [106], [14], [107], [108], [109], [110], [111], [112]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[294], [295], [296]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[297], [298]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[14], [302]
D1538		Tazemetostat	C34H44N4O4	66558664	Moderate		Inter Info	[307]
D1546		Telotristat ethyl	C27H26ClF3N6O3	25181577	Moderate		Inter Info	[14], [311]
D1730		Zonisamide	C8H8N2O3S	5734	Moderate		Inter Info	[313], [314]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[104], [105], [106], [14], [107], [108], [109], [110], [111], [112]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[315], [294], [295], [316], [317], [318], [296]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[104], [105], [106], [14], [107], [108], [109], [110], [111], [112]
D0420		Dapsone (topical)	C12H12N2O2S	2955	Minor		Inter Info	[319], [270], [320]
D0513		Dofetilide	C19H27N3O5S2	71329	Minor		Inter Info	[321]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[323], [324], [325], [326], [327]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[323], [324], [325], [326], [327]
D1716		Zaleplon	C17H15N5O	5719	Minor		Inter Info	[340]
	Competitive inhibition of metabolic enzyme					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[136], [137], [138], [139]
D0696		Fosnetupitant	C31H35F6N4O5P	71544786	Moderate		Inter Info	[20], [259], [260]
D1127		Netupitant	C30H32F6N4O	6451149	Moderate		Inter Info	[20], [259], [260]
	Increased metabolism (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[304], [305], [306]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[304], [305], [306]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[304], [305], [306]
Affected excretion pathways
	Increased renal excretion (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0858		Isoniazid	C6H7N3O	3767	Minor		Inter Info	[337], [338], [339]
Pharmacodynamic additive effects
	Additive immunosuppressive effects					Drug Num: 38
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0348		Cladribine	C10H12ClN5O3	20279	Major		Inter Info	[14], [15]
D0614		Etanercept	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0802		Infliximab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D1111		Natalizumab	NA	NA	Major		Inter Info	[23]
D0146		Baricitinib	C16H17N7O2S	44205240	Major		Inter Info	[27], [28], [29]
D0203		Brexucabtagene autoleucel	NA	NA	Major		Inter Info	[14]
D0304		Certolizumab pegol	NA	NA	Major		Inter Info	[1], [5], [6]
D0501		Dinutuximab	NA	NA	Major		Inter Info	[14]
D0661		Fingolimod	C19H33NO2	107970	Major		Inter Info	[50]
D0736		Golimumab	NA	NA	Major		Inter Info	[1], [2], [3], [4], [5], [6]
D0900		Leflunomide	C12H9F3N2O2	3899	Major		Inter Info	[54], [55]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[14], [56]
D1474		Siponimod	C29H35F3N2O3	44599207	Major		Inter Info	[20], [57]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Major		Inter Info	[54], [55]
D1600		Tofacitinib	C16H20N6O	9926791	Major		Inter Info	[27], [28], [29]
D1666		Upadacitinib	C17H19F3N6O	58557659	Major		Inter Info	[78]
D0032		Alefacept	NA	NA	Moderate		Inter Info	[58], [89], [90]
D0033		Alemtuzumab	NA	NA	Moderate		Inter Info	[91]
D0085		Anakinra	C20H23N5O7S2	146171046	Moderate		Inter Info	[93], [94], [95]
D0553		Efalizumab	NA	NA	Moderate		Inter Info	[169]
D1025		Methotrexate	C20H22N8O5	126941	Moderate		Inter Info	[202], [203], [204]
D0118		Atezolizumab	NA	NA	Moderate		Inter Info	[140], [226], [227], [20], [228], [14], [229], [230], [231], [232]
D0246		Canakinumab	NA	NA	Moderate		Inter Info	[93], [94], [95]
D0299		Cemiplimab	NA	NA	Moderate		Inter Info	[140], [226], [227], [20], [228], [14], [229], [230], [231], [232]
D0443		Denosumab	NA	NA	Moderate		Inter Info	[248]
D0499		Dimethyl fumarate	C6H8O4	637568	Moderate		Inter Info	[249]
D0507		Diroximel fumarate	C11H13NO6	73330464	Moderate		Inter Info	[249]
D0541		Durvalumab	NA	NA	Moderate		Inter Info	[140], [226], [227], [20], [228], [14], [229], [230], [231], [232]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[140], [226], [227], [20], [228], [14], [229], [230], [231], [232]
D1085		Monomethyl fumarate	C5H6O4	5369209	Moderate		Inter Info	[249]
D1150		Nivolumab	NA	NA	Moderate		Inter Info	[140], [226], [227], [20], [228], [14], [229], [230], [231], [232]
D1162		Ocrelizumab	NA	NA	Moderate		Inter Info	[276]
D1174		Omacetaxine mepesuccinate	C29H39NO9	285033	Moderate		Inter Info	[277]
D1240		Pembrolizumab	NA	NA	Moderate		Inter Info	[140], [226], [227], [20], [228], [14], [229], [230], [231], [232]
D1403		Rilonacept	NA	NA	Moderate		Inter Info	[93], [94], [95]
D1422		Roflumilast	C17H14Cl2F2N2O3	449193	Moderate		Inter Info	[14], [299]
D1671		Ustekinumab	NA	NA	Moderate		Inter Info	[312]
	Additive neuromuscular blocking effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0522		Doxacurium	C56H78N2O16+2	60169	Moderate		Inter Info	[140], [14], [250], [251], [252], [253], [254]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[140], [14], [250], [251], [252], [253], [254]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[140], [14], [250], [251], [252], [253], [254]
D1295		Pipecuronium	C35H62N4O4+2	50192	Moderate		Inter Info	[140], [14], [250], [251], [252], [253], [254]
D1384		Rapacuronium	C37H61N2O4+	5311399	Moderate		Inter Info	[140], [14], [250], [251], [252], [253], [254]
D1659		Tubocurarine	C37H41N2O6+	6000	Moderate		Inter Info	[140], [14], [250], [251], [252], [253], [254]
D1684		Vecuronium	C34H57N2O4+	39765	Moderate		Inter Info	[140], [14], [250], [251], [252], [253], [254]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[140], [14], [250], [251], [252], [253], [254]
	Additive thrombogenic effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1569		Thalidomide	C13H10N2O4	5426	Major		Inter Info	[62], [63], [64], [65], [66], [67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77]
	Increased risk of bleeding					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0432		Deferasirox	C21H15N3O4	214348	Major		Inter Info	[47], [48]
D0447		Desirudin	C287H440N80O110S6	16129703	Major		Inter Info	[49]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 27
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0624		Etodolac	C17H21NO3	3308	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0645		Fenoprofen	C15H14O3	3342	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0680		Flurbiprofen	C15H13FO2	3394	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0800		Indomethacin	C19H16ClNO4	3715	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0882		Ketorolac	C15H13NO3	3826	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0991		Mefenamic acid	C15H15NO2	4044	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0995		Meloxicam	C14H13N3O4S2	54677470	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D1097		Nabumetone	C15H16O2	4409	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D1109		Naproxen	C14H14O3	156391	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D1300		Piroxicam	C15H13N3O4S	54676228	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0017		Acetylsalicylic acid	C9H8O4	2244	Moderate		Inter Info	[213], [214], [123]
D0210		Bromfenac	C15H12BrNO3	60726	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0331		Choline salicylate	C12H19NO4	54686350	Moderate		Inter Info	[243], [244], [213], [214], [123]
D0489		Diflunisal	C13H8F2O3	3059	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0786		Ibuprofen	C13H18O2	3672	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0881		Ketoprofen	C16H14O3	3825	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D0988		Meclofenamic acid	C14H11Cl2NO2	4037	Moderate		Inter Info	[122], [126], [127]
D1196		Oxaprozin	C18H15NO3	4614	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D1272		Phenyl salicylate	C13H10O3	8361	Moderate		Inter Info	[213], [214], [123]
D1302		Pitolisant	C17H26ClNO	9948102	Moderate		Inter Info	[14]
D1439		Salicylic acid (sodium)	C7H6O3	338	Moderate		Inter Info	[213], [214], [123]
D1442		Salsalate	C14H10O5	5161	Moderate		Inter Info	[243], [244], [213], [214], [123]
D1421		Rofecoxib	C17H14O4S	5090	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D1520		Sulindac	C20H17FO3S	1548887	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D1606		Tolmetin	C15H15NO3	5509	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
D1674		Valdecoxib	C16H14N2O3S	119607	Moderate		Inter Info	[118], [119], [120], [121], [122], [123], [124], [125], [126], [86], [127]
	Increased risk of hyperammonemia					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0732		Glycerol phenylbutyrate	C33H38O6	10482134	Moderate		Inter Info	[20], [263], [264]
D1275		Phenylbutyric acid	C10H12O2	4775	Moderate		Inter Info	[20], [263], [264]
	Increased risk of hyperglycemia					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0114		Asparaginase Escherichia coli	NA	NA	Moderate		Inter Info	[98], [99], [100]
D0113		Asparaginase Erwinia chrysanthemi	NA	NA	Moderate		Inter Info	[98], [99], [100]
D0232		Calaspargase pegol	NA	NA	Moderate		Inter Info	[98], [99], [100]
	Increased risk of hypokalemia					Drug Num: 53
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[85], [86], [87]
D0075		Amphotericin B	C47H73NO17	5280965	Moderate		Inter Info	[85], [86], [87]
D0076		Amphotericin B (cholesteryl sulfate)	C47H73NO17	5280965	Moderate		Inter Info	[85], [86], [87]
D0077		Amphotericin B (lipid complex)	C47H73NO17	5280965	Moderate		Inter Info	[85], [86], [87]
D0078		Amphotericin B (liposomal)	C47H73NO17	5280965	Moderate		Inter Info	[85], [86], [87]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[85], [86], [87]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[85], [86], [87]
D0252		Capreomycin	C50H88N28O15	3000502	Moderate		Inter Info	[85], [86], [87]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[85], [86], [87]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[85], [86], [87]
D0694		Foscarnet	CH3O5P	3415	Moderate		Inter Info	[85], [86], [87]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[85], [86], [87]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[85], [86], [87]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[85], [86], [87]
D0888		Lactulose	C12H22O11	11333	Moderate		Inter Info	[197], [198], [199]
D0975		Magnesium sulfate	MgO4S	24083	Moderate		Inter Info	[197], [198], [199]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[85], [86], [87]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[85], [86], [87]
D0064		Aminophylline	C16H24N10O4	9433	Moderate		Inter Info	[220], [221], [222]
D0184		Bisacodyl	C22H19NO4	2391	Moderate		Inter Info	[197], [198], [199]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[85], [86], [87]
D0269		Castor oil	C57H104O9	14030006	Moderate		Inter Info	[197], [198], [199]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[85], [86], [87]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[85], [86], [87]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[85], [86], [87]
D0701		Frangula purshiana bark	NA	NA	Moderate		Inter Info	[197], [198], [199]
D0731		Glycerin	C3H8O3	753	Moderate		Inter Info	[197], [198], [199]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[85], [86], [87]
D0887		Lactitol	C12H24O11	157355	Moderate		Inter Info	[197], [198], [199]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[197], [198], [199]
D1069		Mineral oil	NA	NA	Moderate		Inter Info	[197], [198], [199]
D1231		Patiromer	NA	NA	Moderate		Inter Info	[85], [86], [87]
D1266		Phenolphthalein	C20H14O4	4764	Moderate		Inter Info	[197], [198], [199]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[197], [198], [199]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[85], [86], [87]
D1605		Tolevamer	C11H16O3S	58817179	Moderate		Inter Info	[85], [86], [87]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[85], [86], [87]
D1570		Theophylline	C7H8N4O2	2153	Moderate		Inter Info	[220], [221], [222]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[85], [86], [87]
D0854		Isoetharine	C13H21NO3	3762	Minor		Inter Info	[140], [20], [14], [322]
D1185		Orciprenaline	C11H17NO3	4086	Minor		Inter Info	[20], [14], [322]
D0103		Arformoterol	C19H24N2O4	3083544	Minor		Inter Info	[140], [20], [14], [322]
D0691		Formoterol	C19H24N2O4	3410	Minor		Inter Info	[140], [20], [14], [322]
D0797		Indacaterol	C24H28N2O3	6918554	Minor		Inter Info	[140], [20], [14], [322]
D0859		Isoprenaline	C11H17NO3	3779	Minor		Inter Info	[20], [14], [322]
D0924		Levosalbutamol	C13H21NO3	123600	Minor		Inter Info	[20], [14], [322]
D1298		Pirbuterol	C12H20N2O3	4845	Minor		Inter Info	[140], [20], [14], [322]
D1374		Racepinephrine	C9H13NO3	838	Minor		Inter Info	[140], [20], [14], [322]
D1414		Ritodrine	C17H21NO3	33572	Minor		Inter Info	[140], [20], [14], [322]
D1438		Salbutamol	C13H21NO3	2083	Minor		Inter Info	[20], [14], [322]
D1440		Salmeterol	C25H37NO4	5152	Minor		Inter Info	[140], [20], [14], [322]
D1554		Terbutaline	C12H19NO3	5403	Minor		Inter Info	[140], [20], [14], [322]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Minor		Inter Info	[20], [14], [322]
	Increased risk of hyponatremia					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0449		Desmopressin	C46H64N14O12S2	5311065	Major		Inter Info	[16], [14], [17], [18], [19], [20]
	Increased risk of lowers seizure threshold					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43], [44], [45], [46]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[20], [14]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[218], [219]
	Increased risk of tendinitis/tendon rupture					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0340		Cinoxacin	C12H10N2O5	2762	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0341		Ciprofloxacin	C17H18FN3O3	2764	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0573		Enoxacin	C15H17FN4O3	3229	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0740		Grepafloxacin	C19H22FN3O3	72474	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1092		Moxifloxacin	C21H24FN3O4	152946	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1102		Nalidixic acid	C12H12N2O3	4421	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0155		Bempedoic acid	C19H36O5	10472693	Major		Inter Info	[30], [31]
D0438		Delafloxacin	C18H12ClF3N4O4	487101	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0712		Gatifloxacin	C19H22FN3O4	5379	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0716		Gemifloxacin	C18H20FN5O4	9571107	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0919		Levofloxacin	C18H20FN3O4	149096	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D0943		Lomefloxacin	C17H19F2N3O3	3948	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1155		Norfloxacin	C16H18FN3O3	4539	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1165		Ofloxacin	C18H20FN3O4	4583	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1499		Sparfloxacin	C19H22F2N4O3	60464	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
D1657		Trovafloxacin	C20H15F3N4O3	62959	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1195		Oxandrolone	C19H30O3	5878	Moderate		Inter Info	[207], [208]
D0677		Fluoxymesterone	C20H29FO3	6446	Moderate		Inter Info	[207], [208]
D1042		Methyltestosterone	C20H30O2	6010	Moderate		Inter Info	[207], [208]
D1207		Oxymetholone	C21H32O3	5281034	Moderate		Inter Info	[207], [208]
D1503		Stanozolol	C21H32N2O	25249	Moderate		Inter Info	[207], [208]
D1558		Testosterone	C19H28O2	6013	Moderate		Inter Info	[207], [208]
D1559		Testosterone (topical)	C19H28O2	6013	Moderate		Inter Info	[207], [208]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[51], [52], [53]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[51], [52], [53]
D1694		Vigabatrin	C6H11NO2	5665	Major		Inter Info	[79], [80], [81]
D0863		Isotretinoin	C20H28O2	5282379	Moderate		Inter Info	[267], [268], [269]
D1426		Romosozumab	NA	NA	Moderate		Inter Info	[300]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[309], [310]
D1720		Zidovudine	C10H13N5O4	35370	Moderate		Inter Info	[309], [310]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 34
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[82], [83], [84]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[82], [83], [84]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[82], [83], [84]
D0813		Insulin human	C257H383N65O77S6	118984375	Moderate		Inter Info	[82], [83], [84]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[82], [83], [84]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[82], [83], [84]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[82], [83], [84]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[82], [83], [84]
D0818		Insulin human (zinc)	C257H383N65O77S6	118984375	Moderate		Inter Info	[82], [83], [84]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[82], [83], [84]
D0820		Insulin lispro (protamine)	C257H389N65O77S6	16132438	Moderate		Inter Info	[82], [83], [84]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[82], [83], [84]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[82], [83], [84]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[82], [83], [84]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[82], [83], [84]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[82], [83], [84]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[82], [83], [84]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[82], [83], [84]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[82], [83], [84]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[82], [83], [84]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[82], [83], [84]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[82], [83], [84]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[82], [83], [84]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[82], [83], [84]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[82], [83], [84]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[82], [83], [84]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[82], [83], [84]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[82], [83], [84]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[82], [83], [84]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[82], [83], [84]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[82], [83], [84]
D1429		Rosiglitazone	C18H19N3O3S	77999	Moderate		Inter Info	[82], [83], [84]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[82], [83], [84]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[82], [83], [84]
	Antagonize the effect of antihypertensive agents					Drug Num: 59
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[14], [92]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[14], [92]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[14], [92]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[14], [92]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[14], [92]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[14], [92]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[14], [92]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[14], [92]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[14], [92]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[14], [92]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[14], [92]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[14], [92]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[14], [92]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[14], [92]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[14], [92]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[14], [92]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[14], [92]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[14], [92]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[14], [92]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[14], [92]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[14], [92]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[14], [92]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[14], [92]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[14], [92]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[14], [92]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[14], [92]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[14], [92]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[14], [92]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[14], [92]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[14], [92]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[14], [92]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[14], [92]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[14], [92]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[14], [92]
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[82], [83], [84]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[82], [83], [84]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[14], [92]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[14], [92]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[14], [92]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[14], [92]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[14], [92]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[14], [92]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[14], [92]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[14], [92]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[14], [92]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[14], [92]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[14], [92]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[14], [92]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[82], [83], [84]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[14], [92]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[14], [92]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[14], [92]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[14], [92]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[14], [92]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[14], [92]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[14], [92]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[14], [92]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[14], [92]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[14], [92]
	Antagonize the effect of cholinergic agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0052		Ambenonium	C28H42Cl2N4O2+2	2131	Moderate		Inter Info	[215], [216], [217]
D0552		Edrophonium	C10H16NO+	3202	Moderate		Inter Info	[215], [216], [217]
D1122		Neostigmine	C12H19N2O2+	4456	Moderate		Inter Info	[215], [216], [217]
D1365		Pyridostigmine	C9H13N2O2+	4991	Moderate		Inter Info	[215], [216], [217]
	Antagonize the effect of corticosteroids					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1063		Mifepristone	C29H35NO2	55245	Major		Inter Info	[21], [22]
	Antagonize the effect of vaccine/toxoid					Drug Num: 22
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1744		Bacillus calmette-guerin substrain tice live antigen	NA	NA	Major		Inter Info	[24], [25], [26]
D1839		Measles virus vaccine live attenuated	NA	NA	Major		Inter Info	[24], [25], [26]
D1849		Mumps virus strain B level jeryl lynn live antigen	NA	NA	Major		Inter Info	[24], [25], [26]
D1881		Rotavirus vaccine	NA	NA	Major		Inter Info	[24], [25], [26]
D1882		Rubella virus vaccine	NA	NA	Major		Inter Info	[24], [25], [26]
D1890		Smallpox (Vaccinia) Vaccine, Live	NA	NA	Major		Inter Info	[58], [59], [60]
D1897		Talimogene laherparepvec	NA	NA	Major		Inter Info	[61]
D1914		Typhoid vaccine (live)	NA	NA	Major		Inter Info	[24], [25], [26]
D1920		Varicella Zoster Vaccine (Recombinant)	NA	NA	Major		Inter Info	[24], [25], [26]
D1922		Yellow Fever Vaccine	NA	NA	Major		Inter Info	[24], [25], [26]
D1838		Lyme disease vaccine (recombinant OspA)	NA	NA	Moderate		Inter Info	[200]
D0089		Anthrax vaccine	NA	NA	Moderate		Inter Info	[58], [223], [224]
D0366		Clostridium tetani toxoid antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[58], [223], [224]
D0755		Hepatitis A Vaccine	NA	NA	Moderate		Inter Info	[58], [223], [224]
D0756		Hepatitis B Vaccine (Recombinant)	NA	NA	Moderate		Inter Info	[58], [223], [224]
D0767		Human papillomavirus type 11 L1 capsid protein antigen	NA	NA	Moderate		Inter Info	[58], [223], [224]
D0803		Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)	NA	NA	Moderate		Inter Info	[58], [223], [224]
D0804		Influenza A virus A/Vietnam/1194/2004 (H5N1) antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[58], [223], [224]
D1259		Pfizer-BioNTech Covid-19 Vaccine	NA	NA	Moderate		Inter Info	[278], [58], [20], [279], [280], [281], [223], [282], [283], [284], [224]
D1307		Poliovirus type 1 antigen (formaldehyde inactivated)	NA	NA	Moderate		Inter Info	[58], [223], [224]
D1662		Typhoid vaccine (inactivated)	NA	NA	Moderate		Inter Info	[58], [223], [224]
D1692		Vibrio cholerae CVD 103-HgR strain live antigen	NA	NA	Moderate		Inter Info	[58], [223], [224]
	Antagonize the effect of probiotics					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1749		Bifidobacterium longum infantis	NA	NA	Moderate		Inter Info	[236], [237], [238]
D1827		Lactobacillus acidophilus	NA	NA	Moderate		Inter Info	[236], [237], [238]
	Diminish the response to diagnostic skin test antigens					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1755		Candida albicans	C29H27N2O12P	118855431	Moderate		Inter Info	[239], [240], [241]
D1765		Coccidioides immitis spherule	NA	NA	Moderate		Inter Info	[239], [240], [241]
D1912		Trichophyton mentagrophytes	NA	NA	Moderate		Inter Info	[239], [240], [241]
D1913		Tuberculin purified protein derivative	NA	NA	Moderate		Inter Info	[239], [240], [241]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[88]
D1812		Hyaluronidase	C17H24BrNO2	91820602	Minor		Inter Info	[334], [335], [336]
	Antagonize the effects of immunosuppressants					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0545		Echinacea	NA	NA	Minor		Inter Info	[331], [332], [333]
D1722		Zinc acetate	C4H6O4Zn	11192	Minor		Inter Info	[331], [332], [333]
D1723		Zinc chloride	Cl2Zn	5727	Minor		Inter Info	[331], [332], [333]
D1724		Zinc gluconate	C12H22O14Zn	443445	Minor		Inter Info	[331], [332], [333]
D1725		Zinc sulfate	O4SZn	24424	Minor		Inter Info	[331], [332], [333]
D1703		Vitamin E	C29H50O2	14985	Minor		Inter Info	[331], [332], [333]

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