Drug General Information (ID: DDICZEO56N)
Drug Name			Aldesleukin		Drug Info		Zaleplon		Drug Info
Drug Type		Interferons				Small molecule
Therapeutic Class		Antineoplastics				Anxiolytics/Sedatives/Hypnotics

Mechanism of Aldesleukin-Zaleplon Interaction (Severity Level: Moderate)
Additive CNS depression effects Click to Show/Hide Mechanism Graph
Drug Name		Aldesleukin				Zaleplon
Mechanism		CNS depression effects				CNS depression effects
Key Mechanism Factor 1
		Factor Name		CNS depression effects
		Factor Description		CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
Mechanism Description		Additive CNS depression effects by the combination of Aldesleukin and Zaleplon

Recommended Action
Management		Caution is advised if aldesleukin is used with sedatives, hypnotics, tranquilizers, or other CNS-active medications. Patients should be monitored for CNS depression and other CNS adverse effects. Treatment with aldesleukin should be discontinued if severe lethargy or somnolence develop.

References
1	Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
2	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.
3	Cerner Multum, Inc. "UK Summary of Product Characteristics.".