Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDI1PKLEOB)
  Drug Name Aldesleukin Drug Info Clonidine Drug Info
  Drug Type Interferons Small molecule
  Therapeutic Class Antineoplastics Antihypertensive Agents

 Mechanism of Aldesleukin-Clonidine Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Aldesleukin Clonidine
      Mechanism 1 Antihypertensive agent Antihypertensive agent
Alpha-2 adrenergic receptor  Agonist
      Key Mechanism Factor 1
Factor Name Adrenergic receptor alpha-2 Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Aldesleukin and Clonidine 
      Mechanism 2 Hypotensive effects Antihypertensive agent
Alpha-2 adrenergic receptor  Agonist
      Key Mechanism Factor 2
Factor Name Adrenergic receptor alpha-2 Structure Sequence
Protein Family G-protein coupled receptor 1 family
Protein Function
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Aldesleukin and Clonidine 

Recommended Action
      Management Blood pressure should be monitored during concomitant administration. Aldesleukin doses should be held if systolic blood pressure falls to less than 90 mmHg.

References
1 Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.