Drug General Information (ID: DDIJRHC47W)
Drug Name			Aldesleukin		Drug Info		Trimethaphan		Drug Info
Drug Type		Interferons				Small molecule
Therapeutic Class		Antineoplastics				Antihypertensive Agents

Mechanism of Aldesleukin-Trimethaphan Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Aldesleukin				Trimethaphan
Mechanism 1		Antihypertensive agent				Antihypertensive agent Neuronal acetylcholine receptor  Antagonist
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Aldesleukin and Trimethaphan
Mechanism 2		Hypotensive effects				Antihypertensive agent Neuronal acetylcholine receptor  Antagonist
Key Mechanism Factor 2
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Aldesleukin and Trimethaphan

Recommended Action
Management		Blood pressure should be monitored during concomitant administration. Aldesleukin doses should be held if systolic blood pressure falls to less than 90 mmHg.

References
1	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.