Details of Drug

Drug General Information (ID: D1643)
Drug Name	Trimethaphan
Drug Type	Small molecule
Drug Synonymous	Thimethaphan; Trimetaphan; Trimetaphanum; Arfonad (TN); Thieno(1',2':1,2)thieno(3,4-d)imidazol-5-ium, decahydro-2-oxo-1,3-bis(phenylmethyl)-(VAN); 1,3-dibenzyl-2-oxodecahydrothieno[1',2':1,2]thieno[3,4-d]imidazol-5-ium Click to Show/Hide
Disease Class	BD50: Aneurysm/dissection; BA03: Hypertensive crisis
Therapeutic Class	Antihypertensive Agents
Structure
Structure	3D Structure		2D Structure
Formula	C22H25N2OS+
InChI	1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1
InChIKey	CHQOEHPMXSHGCL-UHFFFAOYSA-N
Canonical SMILES	C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5
External Link
	Pubchem ID	23576
	CAS Number	7187-66-8
	CHEBI ID	9728
	TTD ID	D0B6CC

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM038 Additive CNS depression effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM045 Additive neuromuscular blocking effects BM049 Increased risk of atrioventricular block BM089 Antagonize the effect of antihypertensive agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Trimethaphan
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[30], [31], [32]
	Additive hypertensive effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1683		Vasopressin	C46H65N15O12S2	644077	Moderate		Inter Info	[19], [12], [51]
	Additive hypotensive effects					Drug Num: 120
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1596		Tizanidine	C9H8ClN5S	5487	Major		Inter Info	[1]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[2]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[3], [4], [5]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[3], [4], [5]
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[3], [4], [5]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[3], [4], [5]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[6], [7], [8]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[9], [10], [11]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[3], [4], [5]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[9], [10], [11]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[9], [10], [11]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[3], [4], [5]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[3], [4], [5]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[3], [4], [5]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[3], [4], [5]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[3], [4], [5]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[3], [4], [5]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[3], [4], [5]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[14], [15], [16]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[3], [4], [5]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[3], [4], [5]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[3], [4], [5]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[14], [15], [16]
D0379		Codeine	C18H21NO3	5284371	Moderate		Inter Info	[3], [4], [5]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[19], [20], [21]
D0467		Dextropropoxyphene	C22H29NO2	10100	Moderate		Inter Info	[3], [4], [5]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[3], [4], [5]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[3], [4], [5]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[3], [4], [5]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[22], [23]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[14], [15], [16]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[3], [4], [5]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[19], [12], [24]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[14], [15], [16]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[3], [4], [5]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[3], [4], [5]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[3], [4], [5]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[12], [25], [26]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[3], [4], [5]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[27], [28], [29]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[3], [4], [5]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[14], [15], [16]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[3], [4], [5]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[3], [4], [5]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[3], [4], [5]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[14], [15], [16]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[3], [4], [5]
D1023		Methocarbamol	C11H15NO5	4107	Moderate		Inter Info	[3], [4], [5]
D1075		Mirtazapine	C17H19N3	4205	Moderate		Inter Info	[3], [4], [5]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[3], [4], [5]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[3], [4], [5]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[3], [4], [5]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[3], [4], [5]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[14], [15], [16]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[3], [4], [5]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[3], [4], [5]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[3], [4], [5]
D1251		Pentoxifylline	C13H18N4O3	4740	Moderate		Inter Info	[33]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[14], [15], [16]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[14], [15], [16]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[14], [15], [16]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[3], [4], [5]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[27], [28], [29]
D1465		Sildenafil	C22H30N6O4S	135398744	Moderate		Inter Info	[34], [35], [36]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[3], [4], [5]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[14], [15], [16]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[27], [28], [29]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[12], [25], [26]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[14], [15], [16]
D0055		Amifostine	C5H15N2O3PS	2141	Moderate		Inter Info	[6], [22], [37]
D0067		Amisulpride	C17H27N3O4S	2159	Moderate		Inter Info	[14], [15], [16]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[14], [15], [16]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[14], [15], [16]
D0128		Avanafil	C23H26ClN7O3	9869929	Moderate		Inter Info	[34], [35], [36]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[3], [4], [5]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[14], [15], [16]
D0220		Bupropion	C13H18ClNO	444	Moderate		Inter Info	[3], [4], [5]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[19], [12], [38]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[14], [15], [16]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[3], [4], [5]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[19], [12], [38]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[3], [4], [5]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[3], [4], [5]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[3], [4], [5]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[19], [12], [38]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[12], [25], [26]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[14], [15], [16]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[27], [28], [29]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[6], [7], [39]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[12], [43], [30]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[14], [15], [16]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[14], [15], [16]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[44]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[3], [4], [5]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[14], [15], [16]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[32], [45], [30]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[46]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[47], [48], [49]
D1183		Opium	NA	NA	Moderate		Inter Info	[3], [4], [5]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[3], [4], [5]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[27], [28], [29]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[14], [15], [16]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[3], [4], [5]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[27], [28], [29]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[14], [15], [16]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[27], [28], [29]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[3], [4], [5]
D1408		Riociguat	C20H19FN8O2	11304743	Moderate		Inter Info	[50]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[27], [28], [29]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[12], [25], [26]
D1485		Sodium oxybate	C4H7NaO3	23663870	Moderate		Inter Info	[3], [4], [5]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[3], [4], [5]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[14], [15], [16]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[3], [4], [5]
D1682		Vardenafil	C23H32N6O4S	135400189	Moderate		Inter Info	[34], [35], [36]
D1716		Zaleplon	C17H15N5O	5719	Moderate		Inter Info	[3], [4], [5]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[14], [15], [16]
D1729		Zolpidem	C19H21N3O	5732	Moderate		Inter Info	[3], [4], [5]
D1527		Tadalafil	C22H19N3O4	110635	Minor		Inter Info	[53], [54]
D0711		Garlic	NA	NA	Minor		Inter Info	[55], [56]
	Additive neuromuscular blocking effects					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0343		Cisatracurium	C53H72N2O12+2	62887	Moderate		Inter Info	[13], [17]
D1420		Rocuronium	C32H53N2O4+	441290	Moderate		Inter Info	[13], [17]
D1510		Succinylcholine	C14H30N2O4+2	5314	Moderate		Inter Info	[13], [17]
D0122		Atracurium	C53H72N2O12+2	47319	Moderate		Inter Info	[13], [17]
D1080		Mivacurium	C58H80N2O14+2	5281042	Moderate		Inter Info	[13], [17]
D1219		Pancuronium	C35H60N2O4+2	441289	Moderate		Inter Info	[13], [17]
	Increased risk of atrioventricular block					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[18]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antihypertensive agents					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0172		Betamethasone	C22H29FO5	9782	Moderate		Inter Info	[12], [13]
D1041		Methylprednisolone	C22H30O5	6741	Moderate		Inter Info	[12], [13]
D1332		Prednisolone	C21H28O5	5755	Moderate		Inter Info	[12], [13]
D1334		Prednisone	C21H26O5	5865	Moderate		Inter Info	[12], [13]
D1628		Triamcinolone	C21H27FO6	31307	Moderate		Inter Info	[12], [13]
D0215		Budesonide	C25H34O6	5281004	Moderate		Inter Info	[12], [13]
D0392		Corticotropin	C207H308N56O58S	16132265	Moderate		Inter Info	[12], [13]
D0436		Deflazacort	C25H31NO6	189821	Moderate		Inter Info	[12], [13]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[12], [13]
D0926		Licorice	C42H62O16Zn	163463	Moderate		Inter Info	[40], [41], [42]
D1563		Tetracosactide	C136H210N40O31S	16133802	Moderate		Inter Info	[12], [13]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[52], [22]

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54	Product Information. Rapaflo (silodosin). Watson Pharmaceuticals, Corona, CA.
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