Details of Drug Interaction

Details of Drug-Drug Interaction

 Drug General Information (ID: DDIL1OAUH0)
  Drug Name Trimethaphan Drug Info Levodopa Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antihypertensive Agents Dopaminergic Antiparkinsonism Agents
  Structure

 Mechanism of Trimethaphan-Levodopa Interaction (Severity Level: Moderate)
     Additive hypotensive effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Trimethaphan Levodopa
      Mechanism 1 Antihypertensive agent
Neuronal acetylcholine receptor  Antagonist 		Antihypertensive agent
      Key Mechanism Factor 1
Factor Name Neuronal acetylcholine receptor Structure Sequence
Protein Family Ligand-gated ion channel (TC 1.A.9) family
Protein Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Trimethaphan and Levodopa 
      Mechanism 2 Antihypertensive agent
Neuronal acetylcholine receptor  Antagonist 		Hypotensive effects
      Key Mechanism Factor 2
Factor Name Neuronal acetylcholine receptor Structure Sequence
Protein Family Ligand-gated ion channel (TC 1.A.9) family
Protein Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    Click to Show/Hide
      Mechanism Description
  • Additive hypotensive effects by the combination of Trimethaphan and Levodopa 

Recommended Action
      Management Hemodynamic responses should be monitored during coadministration, especially during the first few weeks of therapy. Dose adjustments of the antihypertensive agent may be required. Patients should be advised to notify their physician if they experience dizziness or syncope.

References
1 Bailey DG, Dresser GK "Natural products and adverse drug interactions." Can Med Assoc J 170 (2004): 1531-2. [PMID: 15136542]
2 Ho PC, Ghose K, Saville D, Wanwimolruk S "Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers." Eur J Clin Pharmacol 56 (2000): 693-8. [PMID: 11214778]
3 Product Information. Stalevo 150 (carbidopa/entacapone/levodopa). Novartis Pharmaceuticals, East Hanover, NJ.