Details of Drug

Drug General Information (ID: D0918)
Drug Name	Levodopa
Drug Type	Small molecule
Drug Synonymous	Levodopa (optimized formulation, Parkinson's disease); More effective levodopa (Parkinson's disease), Orion; Levodopa (optimized formulation, Parkinson's disease), Orion Click to Show/Hide
Disease Class	8A00: Parkinsonism
Therapeutic Class	Dopaminergic Antiparkinsonism Agents
Structure
Structure	3D Structure		2D Structure
Formula	C9H11NO4
InChI	1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
InChIKey	WTDRDQBEARUVNC-LURJTMIESA-N
Canonical SMILES	C1=CC(=C(C=C1CC(C(=O)O)N)O)O
External Link
	Pubchem ID	6047
	CAS Number	59-92-7
	CHEBI ID	15765
	TTD ID	D08HVR
	INTEDE ID	DR0939
	VARIDT ID	DR00125

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM001 Altered gastrointestinal dynamics BM003 Complex formation BM005 Altered gastric pH BM017 CYP450 enzyme inhibition BM018 Non-CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM038 Additive CNS depression effects BM040 Additive dopaminergic effects BM041 Additive hypertensive effects BM042 Additive hypotensive effects BM074 Increased risk of peripheral neuropathy BM078 Increased risk of rapid heart rate BM083 Potentiated the pharmacological effects (Unspecific) BM093 Antagonize the effect of dopaminergic agents BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Levodopa
Affected gastrointestinal absorption
	Altered gastrointestinal dynamics					Drug Num: 28
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[85], [86], [90]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[85], [86], [90]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1354		Propantheline	C23H30NO3+	4934	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[85], [131], [90]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[85], [86], [87], [88], [89], [90]
D0068		Amitriptyline	C20H23N	2160	Minor		Inter Info	[133], [134]
D0446		Desipramine	C18H22N2	2995	Minor		Inter Info	[133], [134]
D0525		Doxepin	C19H21NO	667477	Minor		Inter Info	[133], [134]
D0795		Imipramine	C19H24N2	3696	Minor		Inter Info	[133], [134]
D0361		Clomipramine	C19H23ClN2	2801	Minor		Inter Info	[133], [134]
D1158		Nortriptyline	C19H21N	4543	Minor		Inter Info	[133], [134]
D1361		Protriptyline	C19H21N	4976	Minor		Inter Info	[133], [134]
D1647		Trimipramine	C20H26N2	5584	Minor		Inter Info	[133], [134]
	Complex formation					Drug Num: 6
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0649		Ferrous fumarate	C4H2FeO4	6433164	Moderate		Inter Info	[112], [113], [114], [115]
D0650		Ferrous gluconate	C12H22FeO14	23616740	Moderate		Inter Info	[112], [113], [114], [115]
D0651		Ferrous sulfate anhydrous	FeO4S	24393	Moderate		Inter Info	[112], [113], [114]
D0847		Iron	Fe	23925	Moderate		Inter Info	[112], [113], [114]
D0849		Iron protein succinylate	NA	NA	Moderate		Inter Info	[112], [113], [114], [115]
D1566		Tetraferric tricitrate decahydrate	C18H32Fe4O31	90478690	Moderate		Inter Info	[112], [113], [114]
	Altered gastric pH					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Minor		Inter Info	[88], [15], [90], [135]
D0236		Calcium carbonate	CCaO3	10112	Minor		Inter Info	[88], [15], [90], [135]
D0967		Magaldrate	AlHMgO5S+2	3086011	Minor		Inter Info	[88], [15], [90], [135]
D0968		Magnesium carbonate	CMgO3	11029	Minor		Inter Info	[88], [15], [90], [135]
D0973		Magnesium hydroxide	H2MgO2	14791	Minor		Inter Info	[88], [15], [90], [135]
D0974		Magnesium oxide	MgO	14792	Minor		Inter Info	[88], [15], [90], [135]
D1480		Sodium bicarbonate	CHNaO3	516892	Minor		Inter Info	[88], [15], [90], [135]
Affected intra/extra-hepatic metabolism
	Non-CYP450 enzyme inhibition					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[95], [96], [97], [98], [99], [100], [101]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[95], [96], [97], [98], [99], [100], [101]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[95], [96], [97], [98], [99], [100], [101]
Pharmacodynamic additive effects
	Additive CNS depression effects					Drug Num: 37
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[1], [2], [3]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[59], [60]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[83], [84]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[45], [5], [49]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[45], [5], [49]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[45], [5], [49]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[102], [103], [76], [5], [104]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[105], [102], [106]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[110]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[4], [111]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[116]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[119], [120], [121]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[122]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1019		Methdilazine	C18H20N2S	14677	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1046		Metoclopramide	C14H22ClN3O2	4168	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [77], [78], [79], [80], [81], [82]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1346		Prochlorperazine	C20H24ClN3S	4917	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1351		Promazine	C17H20N2S	4926	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1355		Propiomazine	C20H24N2OS	4940	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1572		Thiethylperazine	C22H29N3S2	5440	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1574		Thioridazine	C21H26N2S2	5452	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[130]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1638		Triflupromazine	C18H19F3N2S	5568	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
	Additive dopaminergic effects					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[123]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[124]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[127], [70]
D0346		Citicoline	C14H26N4O11P2	13804	Minor		Inter Info	[136]
D0998		Memantine	C12H21N	4054	Minor		Inter Info	[5], [137]
	Additive hypertensive effects					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0853		Isocarboxazid	C12H13N3O2	3759	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1036		Methylene blue	C16H18ClN3S	6099	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1211		Ozanimod	C23H24N4O3	52938427	Major		Inter Info	[7], [23], [8], [4], [5], [24], [25], [26], [9], [27], [10], [28], [11], [29], [30], [31], [32], [12], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [13], [43], [44], [45], [46], [47], [48], [49], [14], [50], [15], [16], [51], [52], [53], [54], [17], [55], [18], [19], [20], [56], [21], [57], [58], [22]
D0933		Linezolid	C16H20FN3O4	441401	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1263		Phenelzine	C8H12N2	3675	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1345		Procarbazine	C12H19N3O	4915	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D1620		Tranylcypromine	C9H11N	19493	Major		Inter Info	[7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[4], [5], [107]
	Additive hypotensive effects					Drug Num: 72
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[61], [62], [63]
D0012		Acetazolamide	C4H6N4O3S2	1986	Moderate		Inter Info	[61], [62], [63]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[61], [62], [63]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[61], [62], [63]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[61], [62], [63]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[61], [62], [63]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[61], [62], [63]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[61], [62], [63]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[61], [62], [63]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[61], [62], [63]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[61], [62], [63]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[61], [62], [63]
D0265		Carteolol	C16H24N2O3	2583	Moderate		Inter Info	[61], [62], [63]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[61], [62], [63]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[61], [62], [63]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[61], [62], [63]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[61], [62], [63]
D0479		Diclofenamide	C6H6Cl2N2O4S2	3038	Moderate		Inter Info	[61], [62], [63]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[61], [62], [63]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[61], [62], [63]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[61], [62], [63]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[61], [62], [63]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[61], [62], [63]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[61], [62], [63]
D0640		Felodipine	C18H19Cl2NO4	3333	Moderate		Inter Info	[61], [62], [63]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[61], [62], [63]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[61], [62], [63]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[61], [62], [63]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[61], [62], [63]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[61], [62], [63]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[61], [62], [63]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[61], [62], [63]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[61], [62], [63]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[61], [62], [63]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[61], [62], [63]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[61], [62], [63]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[61], [62], [63]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[61], [62], [63]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[61], [62], [63]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[61], [62], [63]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[61], [62], [63]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[61], [62], [63]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[61], [62], [63]
D1018		Methazolamide	C5H8N4O3S2	4100	Moderate		Inter Info	[61], [62], [63]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[61], [62], [63]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[61], [62], [63]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[61], [62], [63]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[61], [62], [63]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[61], [62], [63]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[61], [62], [63]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[61], [62], [63]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[61], [62], [63]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[61], [62], [63]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[61], [62], [63]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[61], [62], [63]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[61], [62], [63]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[61], [62], [63]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[61], [62], [63]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[61], [62], [63]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[61], [62], [63]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[61], [62], [63]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[61], [62], [63]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[61], [62], [63]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[61], [62], [63]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[61], [62], [63]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[61], [62], [63]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[61], [62], [63]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[61], [62], [63]
D1633		Trichlormethiazide	C8H8Cl3N3O4S2	5560	Moderate		Inter Info	[61], [62], [63]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[61], [62], [63]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[61], [62], [63]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[61], [62], [63]
	Increased risk of peripheral neuropathy					Drug Num: 77
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0023		Adalimumab	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0120		Atorvastatin	C33H35FN2O5	60823	Moderate		Inter Info	[64], [65], [66]
D0126		Auranofin	C20H34AuO9PS	24199313	Moderate		Inter Info	[64], [65], [66]
D0193		Bortezomib	C19H25BN4O4	387447	Moderate		Inter Info	[91], [92], [93]
D0260		Carboplatin	C6H12N2O4Pt	426756	Moderate		Inter Info	[64], [65], [66]
D0303		Cerivastatin	C26H34FNO5	446156	Moderate		Inter Info	[64], [65], [66]
D0313		Chloramphenicol	C11H12Cl2N2O5	5959	Moderate		Inter Info	[64], [65], [66]
D0320		Chloroquine	C18H26ClN3	2719	Moderate		Inter Info	[64], [65], [66]
D0344		Cisplatin	Cl2H6N2Pt	5702198	Moderate		Inter Info	[64], [65], [66]
D0419		Dapsone	C12H12N2O2S	2955	Moderate		Inter Info	[64], [65], [66]
D0483		Didanosine	C10H12N4O3	135398739	Moderate		Inter Info	[64], [65], [66]
D0509		Disulfiram	C10H20N2S4	3117	Moderate		Inter Info	[64], [65], [66]
D0614		Etanercept	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0616		Ethambutol	C10H24N2O2	14052	Moderate		Inter Info	[64], [65], [66]
D1731		Ethionamide	C8H10N2S	2761171	Moderate		Inter Info	[64], [65], [66]
D0627		Etoposide	C29H32O13	36462	Moderate		Inter Info	[64], [65], [66]
D0669		Fludarabine	C10H12FN5O4	657237	Moderate		Inter Info	[64], [65], [66]
D0686		Fluvastatin	C24H26FNO4	446155	Moderate		Inter Info	[64], [65], [66]
D0802		Infliximab	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0821		Interferon alfa-2a, Recombinant	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0822		Interferon alfa-2b	C16H17Cl3I2N3NaO5S	71306834	Moderate		Inter Info	[64], [65], [66]
D0824		Interferon alfa-n1	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0823		Interferon alfacon-1	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0858		Isoniazid	C6H7N3O	3767	Moderate		Inter Info	[64], [65], [66]
D0900		Leflunomide	C12H9F3N2O2	3899	Moderate		Inter Info	[64], [65], [66]
D0127		Aurothioglucose	C6H11AuO5S	454937	Moderate		Inter Info	[64], [65], [66]
D0162		Benznidazole	C12H12N4O3	31593	Moderate		Inter Info	[64], [65], [66]
D0199		Brentuximab vedotin	NA	NA	Moderate		Inter Info	[64], [108], [109]
D0227		Cabazitaxel	C45H57NO14	9854073	Moderate		Inter Info	[64], [65], [66]
D0261		Carfilzomib	C40H57N5O7	11556711	Moderate		Inter Info	[64], [65], [66]
D0304		Certolizumab pegol	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0380		Colchicine	C22H25NO6	6167	Moderate		Inter Info	[64], [65], [66]
D0496		Diiodohydroxyquinoline	C9H5I2NO	3728	Moderate		Inter Info	[64], [65], [66]
D0501		Dinutuximab	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0511		Docetaxel	C43H53NO14	148124	Moderate		Inter Info	[64], [65], [66]
D0560		Elotuzumab	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0571		Enfortumab vedotin	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0594		Eribulin	C40H59NO11	11354606	Moderate		Inter Info	[64], [65], [66]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[64], [65], [66]
D0736		Golimumab	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0779		Hydroxychloroquine	C18H26ClN3O	3652	Moderate		Inter Info	[64], [65], [66]
D0841		Ipilimumab	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0873		Ixabepilone	C27H42N2O5S	6445540	Moderate		Inter Info	[64], [65], [66]
D0874		Ixazomib	C14H19BCl2N2O4	25183872	Moderate		Inter Info	[64], [65], [66]
D1113		Naxitamab	NA	NA	Moderate		Inter Info	[64], [65], [66]
D1118		Nelarabine	C11H15N5O5	3011155	Moderate		Inter Info	[64], [65], [66]
D1301		Pitavastatin	C25H24FNO4	5282452	Moderate		Inter Info	[64], [65], [66]
D1306		Polatuzumab vedotin	NA	NA	Moderate		Inter Info	[64], [65], [66]
D1312		Pomalidomide	C13H11N3O4	134780	Moderate		Inter Info	[64], [65], [66]
D1452		Secnidazole	C7H11N3O3	71815	Moderate		Inter Info	[64], [65], [66]
D1479		Sodium aurothiomalate	C4H3AuNa2O4S	22318	Moderate		Inter Info	[64], [65], [66]
D1543		Telbivudine	C10H14N2O5	159269	Moderate		Inter Info	[64], [65], [66]
D1556		Teriflunomide	C12H9F3N2O2	54684141	Moderate		Inter Info	[64], [65], [66]
D1599		Tocilizumab	NA	NA	Moderate		Inter Info	[64], [65], [66]
D1615		Trabectedin	C39H43N3O11S	108150	Moderate		Inter Info	[64], [65], [66]
D1623		Trastuzumab emtansine	NA	NA	Moderate		Inter Info	[64], [65], [66]
D0956		Lovastatin	C24H36O5	53232	Moderate		Inter Info	[64], [65], [66]
D1051		Metronidazole	C6H9N3O3	4173	Moderate		Inter Info	[64], [65], [66]
D1145		Nitrofurantoin	C8H6N4O5	6604200	Moderate		Inter Info	[64], [65], [66]
D1193		Oxaliplatin	C8H14N2O4Pt	9887053	Moderate		Inter Info	[64], [65], [66]
D1212		Paclitaxel	C47H51NO14	36314	Moderate		Inter Info	[64], [65], [66]
D1213		Paclitaxel (protein-bound)	C47H51NO14	36314	Moderate		Inter Info	[64], [65], [66]
D1237		Peginterferon alfa-2a	NA	NA	Moderate		Inter Info	[64], [65], [66]
D1238		Peginterferon alfa-2b	NA	NA	Moderate		Inter Info	[64], [65], [66]
D1329		Pravastatin	C23H36O7	54687	Moderate		Inter Info	[64], [65], [66]
D1430		Rosuvastatin	C22H28FN3O6S	446157	Moderate		Inter Info	[64], [65], [66]
D1473		Simvastatin	C25H38O5	54454	Moderate		Inter Info	[64], [65], [66]
D1504		Stavudine	C10H12N2O4	18283	Moderate		Inter Info	[64], [65], [66]
D1551		Teniposide	C32H32O13S	452548	Moderate		Inter Info	[64], [65], [66]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[91], [4], [5], [129]
D1587		Tinidazole	C8H13N3O4S	5479	Moderate		Inter Info	[64], [65], [66]
D1697		Vinblastine	C46H58N4O9	13342	Moderate		Inter Info	[64], [65], [66]
D1698		Vincristine	C46H56N4O10	5978	Moderate		Inter Info	[64], [65], [66]
D1699		Vincristine (liposome)	C46H56N4O10	5978	Moderate		Inter Info	[64], [65], [66]
D1700		Vinorelbine	C45H54N4O8	5311497	Moderate		Inter Info	[64], [65], [66]
D1714		Zafirlukast	C31H33N3O6S	5717	Moderate		Inter Info	[64], [65], [66]
D1715		Zalcitabine	C9H13N3O3	24066	Moderate		Inter Info	[91], [132]
	Potentiated the pharmacological effects (Unspecific)					Drug Num: 7
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[4], [5], [94]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[4], [5], [94]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[4], [5], [94]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[4], [5], [94]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[4], [5], [94]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[4], [5], [94]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[4], [5], [94]
Pharmacodynamic antagonistic effects
	Antagonize the effect of dopaminergic agents					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0067		Amisulpride	C17H27N3O4S	2159	Major		Inter Info	[4], [5], [6]
D0037		Alimemazine	C18H22N2S	5574	Moderate		Inter Info	[71], [75], [81]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D0961		Lurasidone	C28H36N4O2S	213046	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1026		Methotrimeprazine	C19H24N2OS	72287	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1215		Paliperidone	C23H27FN4O3	115237	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1560		Tetrabenazine	C19H27NO3	6018	Moderate		Inter Info	[125], [126]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[67], [68], [69], [70], [71], [72], [73], [74], [75], [76], [77], [78], [79], [80], [81], [82]
D1872		Pyridoxine	C8H11NO3	1054	Moderate		Inter Info	[5], [128]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[4], [117], [118]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[4], [117], [118]

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53	Product Information. Vyvanse (lisdexamfetamine). Shire US Inc, Florence, KY.
54	Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
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