Drug General Information (ID: DDIAZMCDLU)
Drug Name			Levodopa		Drug Info		Clomipramine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Dopaminergic Antiparkinsonism Agents				Antidepressants
Structure

Mechanism of Levodopa-Clomipramine Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Levodopa				Clomipramine
Mechanism		Absorption affected by delayed gastric emptying				Delayed gastric emptying
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Levodopa due to GI dynamics variation caused by Clomipramine

References
1	Morgan JP, Rivera-Calimlim L, Messiha F, Sundaresan PR, Trabert N "Imipramine-mediated interference with levodopa absorption from the gastrointestinal tract in man." Neurology 25 (1975): 1029-34. [PMID: 1237820]
2	Rampton DS "Hypertensive crisis in a patient given Sinemet, metoclopramide, and amitriptyline." Br Med J 2 (1977): 607-8. [PMID: 901999]