Drug General Information (ID: DDILQ6WFEI)
Drug Name			Phenylpropanolamine		Drug Info		Levodopa		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Appetite Depressants				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Phenylpropanolamine-Levodopa Interaction (Severity Level: Moderate)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Phenylpropanolamine				Levodopa
Mechanism		Sympathomimetic amine				Potentiate the pharmacologic effects of sympathomimetic amine
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Phenylpropanolamine and Levodopa

Recommended Action
Management		The use of levodopa with sympathomimetic agents should generally be avoided. If concomitant use is required, close monitoring of the cardiovascular system is recommended and the dose of the sympathomimetic agent may need to be reduced.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
3	Wohlt PD, Zheng L, Gunderson S, Balzar SA, Johnson BD, Fish JT "Recommendations for the use of medications with continuous enteral nutrition." Am J Health Syst Pharm 66 (2009): 1438-67. [PMID: 19667002]