Drug General Information (ID: D1281)
  Drug Name
Phenylpropanolamine
  Drug Type Small molecule
  Drug Synonymous
Norephedrine; phenylpropanolamine; Rhindecon; dl-Norephedrine; (+)-Norephedrine; Propagest; Dexatrim; Mucron; d-Norephedrine; Propadrine; 1r,2s-phenylpropylamine; Super Odrinex; 14838-15-4; (1S,2R)-2-amino-1-phenylpropan-1-ol; Fenilpropanolamina; dl-1-Phenyl-2-aminopropanol-1; UNII-7875H6443P; Phenylpropanolaminum; (+-)-Norephedrin; dl-Phenylpropanolamine; dl-2-Amino-1-hydroxy-1-phenylpropane; CHEBI:36; Naldecon; Cathinum [INN-Latin]; (+-)-Phenylpropanolamine; NSC9920; DLNKOYKMWOXYQA-VXNVDRBHSA-N; 37577-28-9; Cathina [INN-Spanish]; Acutrim; Cathina; Cathine; Cathinum; Codimal; Conex; Contuss; Despec; Exponcit; Fansia; Fugoa; Gentab; Guaipax; Katine; Minusine; Mydriatin; Myminic; Nolex; Norpseudoephedrine; Partuss; Phenoxine; Phenyldrine; Phenylfenesin; Phenylpropanolamina; Pseudonorephedrine; Rhymed; Snaplets; ULR; Vanex; Cathine [INN]; Fugoa Depot; Ami-Tex; D-Norpseudoephedrine; Dl-Norephedrine; Dura-Vent; Fansia (TN); L-Norephedrine; Proin (TN); Propalin (TN); Psi-Norephedrine; TAVIST-D; USAF CS-6; D-Nor-psi-ephedrine; L-Nor-psi-ephedrin; L-Nor-psi-ephedrine; D-(+)-Norephedrine; L-(-)-Norephedrine; (+-)-Norephedrine; (+/-)-Norephedrin; (+/-)-Norephedrine; (-)-Norephedrin; (-)-Norephedrine; (1R,2S)-Norephedrine
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  Disease Class 5B80-5B81: Obesity
  Therapeutic Class Appetite Depressants
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C9H13NO
  InChI 1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9-/m1/s1
  InChIKey DLNKOYKMWOXYQA-VXNVDRBHSA-N
  Canonical SMILES CC(C(C1=CC=CC=C1)O)N
  External Link
Pubchem ID 26934
CAS Number 37577-28-9
CHEBI ID 36
TTD ID D09JXM

Drug-Drug Interaction Network
  Sunburst Graph
AM003  Affected organization distribution
AM006  Pharmacodynamic additive effects
AM007  Pharmacodynamic antagonistic effects
BM014  Interference of cell/tissue uptake
BM041  Additive hypertensive effects
BM042  Additive hypotensive effects
BM061  Increased risk of hyperpyrexia
BM069  Increased risk of lowers seizure threshold
BM081  Increased risk of ventricular arrhythmias
BM083  Potentiated the pharmacological effects (Unspecific)
BM086  Antagonize the effect of antidiabetic agents
BM089  Antagonize the effect of antihypertensive agents
BM093  Antagonize the effect of dopaminergic agents
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Phenylpropanolamine
      Affected organization distribution
   Interference of cell/tissue uptake Drug Num:  2
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0829
 
Iobenguane (I-131)
 
C8H10IN3
 
60860 
Major    Inter Info   
[31]
D1821
 
Iobenguane (I-123)
 
C8H10IN3
 
60860 
Moderate    Inter Info   
[130], [12], [131]
      Pharmacodynamic additive effects
   Additive hypertensive effects Drug Num:  67
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0345
 
Citalopram
 
C20H21FN2O
 
2771 
Major    Inter Info   
[1], [2], [3]
D0494
 
Dihydroergotamine
 
C33H37N5O5
 
10531 
Major    Inter Info   
[4], [5], [6], [7]
D0687
 
Fluvoxamine
 
C15H21F3N2O2
 
5324346 
Major    Inter Info   
[1], [2], [3]
D1037
 
Methylergometrine
 
C20H25N3O2
 
8226 
Major    Inter Info   
[4], [7], [8]
D1043
 
Methysergide
 
C21H27N3O2
 
9681 
Major    Inter Info   
[4], [7], [8]
D0212
 
Bromocriptine
 
C32H40BrN5O5
 
31101 
Major    Inter Info   
[12], [13], [14]
D0451
 
Desvenlafaxine
 
C16H25NO2
 
125017 
Major    Inter Info   
[1], [2], [3]
D0539
 
Duloxetine
 
C18H19NOS
 
60835 
Major    Inter Info   
[1], [2], [3]
D0592
 
Ergometrine
 
C19H23N3O2
 
443884 
Major    Inter Info   
[4], [7], [8]
D0593
 
Ergotamine
 
C33H35N5O5
 
8223 
Major    Inter Info   
[4], [5], [6], [30], [7], [8]
D0599
 
Escitalopram
 
C20H21FN2O
 
146570 
Major    Inter Info   
[1], [2], [3]
D0676
 
Fluoxetine
 
C17H18F3NO
 
3386 
Major    Inter Info   
[1], [2], [3]
D0920
 
Levomilnacipran
 
C15H22N2O
 
6917779 
Major    Inter Info   
[1], [2], [3]
D1066
 
Milnacipran
 
C15H22N2O
 
65833 
Major    Inter Info   
[1], [2], [3]
D1229
 
Paroxetine
 
C19H20FNO3
 
43815 
Major    Inter Info   
[1], [2], [3]
D1461
 
Sertraline
 
C17H17Cl2N
 
68617 
Major    Inter Info   
[1], [2], [3]
D1464
 
Sibutramine
 
C17H26ClN
 
5210 
Major    Inter Info   
[1], [2], [3]
D1696
 
Vilazodone
 
C26H27N5O2
 
6918314 
Major    Inter Info   
[1], [2], [3]
D1708
 
Vortioxetine
 
C18H22N2S
 
9966051 
Major    Inter Info   
[1], [2], [3]
D1689
 
Venlafaxine
 
C17H27NO2
 
5656 
Major    Inter Info   
[1], [2], [3]
D0068
 
Amitriptyline
 
C20H23N
 
2160 
Moderate    Inter Info   
[65], [66], [67]
D0074
 
Amphetamine
 
C9H13N
 
3007 
Moderate    Inter Info   
[68], [69], [70]
D0119
 
Atomoxetine
 
C17H21NO
 
54841 
Moderate    Inter Info   
[68], [69], [70]
D0854
 
Isoetharine
 
C13H21NO3
 
3762 
Moderate    Inter Info   
[68], [69], [70]
D1061
 
Midodrine
 
C12H18N2O4
 
4195 
Moderate    Inter Info   
[80], [8]
D1153
 
Norepinephrine
 
C8H11NO3
 
439260 
Moderate    Inter Info   
[68], [69], [70]
D1210
 
Oxytocin
 
C43H66N12O12S2
 
439302 
Moderate    Inter Info   
[80], [81], [82]
D1276
 
Phenylephrine
 
C9H13NO2
 
6041 
Moderate    Inter Info   
[68], [69], [70]
D0072
 
Amoxapine
 
C17H16ClN3O
 
2170 
Moderate    Inter Info   
[65], [66], [67]
D0103
 
Arformoterol
 
C19H24N2O4
 
3083544 
Moderate    Inter Info   
[68], [69], [70]
D0361
 
Clomipramine
 
C19H23ClN2
 
2801 
Moderate    Inter Info   
[65], [66], [67]
D0446
 
Desipramine
 
C18H22N2
 
2995 
Moderate    Inter Info   
[65], [66], [67]
D0460
 
Dexmethylphenidate
 
C14H19NO2
 
154101 
Moderate    Inter Info   
[68], [69], [70]
D0465
 
Dextroamphetamine
 
C9H13N
 
5826 
Moderate    Inter Info   
[68], [69], [70]
D0510
 
Dobutamine
 
C18H23NO3
 
36811 
Moderate    Inter Info   
[68], [69], [70]
D0517
 
Dopamine
 
C8H11NO2
 
681 
Moderate    Inter Info   
[68], [69], [70]
D0523
 
Doxapram
 
C24H30N2O2
 
3156 
Moderate    Inter Info   
[68], [69], [70]
D0525
 
Doxepin
 
C19H21NO
 
667477 
Moderate    Inter Info   
[65], [66], [67]
D0526
 
Doxepin (topical)
 
C19H21NO
 
667477 
Moderate    Inter Info   
[65], [66], [67]
D0538
 
Droxidopa
 
C9H11NO5
 
92974 
Moderate    Inter Info   
[118]
D0579
 
Ephedrine
 
C10H15NO
 
9294 
Moderate    Inter Info   
[68], [69], [70]
D0581
 
Epinephrine
 
C9H13NO3
 
5816 
Moderate    Inter Info   
[68], [69], [70]
D0691
 
Formoterol
 
C19H24N2O4
 
3410 
Moderate    Inter Info   
[68], [69], [70]
D0795
 
Imipramine
 
C19H24N2
 
3696 
Moderate    Inter Info   
[65], [66], [67]
D0797
 
Indacaterol
 
C24H28N2O3
 
6918554 
Moderate    Inter Info   
[68], [69], [70]
D0857
 
Isometheptene
 
C9H19N
 
22297 
Moderate    Inter Info   
[68], [69], [70]
D0859
 
Isoprenaline
 
C11H17NO3
 
3779 
Moderate    Inter Info   
[68], [69], [70]
D0921
 
Levonordefrin
 
C9H13NO3
 
164739 
Moderate    Inter Info   
[68], [69], [70]
D0924
 
Levosalbutamol
 
C13H21NO3
 
123600 
Moderate    Inter Info   
[68], [69], [70]
D0937
 
Lisdexamfetamine
 
C15H25N3O
 
11597698 
Moderate    Inter Info   
[68], [69], [70]
D1002
 
Mephentermine
 
C11H17N
 
3677 
Moderate    Inter Info   
[68], [69], [70]
D1013
 
Metaraminol
 
C9H13NO2
 
5906 
Moderate    Inter Info   
[68], [69], [70]
D1027
 
Methoxamine
 
C11H17NO3
 
6082 
Moderate    Inter Info   
[68], [69], [70]
D1039
 
Methylphenidate
 
C14H19NO2
 
4158 
Moderate    Inter Info   
[68], [69], [70]
D1158
 
Nortriptyline
 
C19H21N
 
4543 
Moderate    Inter Info   
[65], [66], [67]
D1171
 
Olodaterol
 
C21H26N2O5
 
11504295 
Moderate    Inter Info   
[68], [69], [70]
D1185
 
Orciprenaline
 
C11H17NO3
 
4086 
Moderate    Inter Info   
[68], [69], [70]
D1298
 
Pirbuterol
 
C12H20N2O3
 
4845 
Moderate    Inter Info   
[68], [69], [70]
D1363
 
Pseudoephedrine
 
C10H15NO
 
7028 
Moderate    Inter Info   
[68], [69], [70]
D1374
 
Racepinephrine
 
C9H13NO3
 
838 
Moderate    Inter Info   
[68], [69], [70]
D1385
 
Rasagiline
 
C12H13N
 
3052776 
Moderate    Inter Info   
[37], [38], [137], [80], [39], [139], [40], [41], [43], [44], [45], [46], [47], [48], [142], [50], [84], [51], [163], [113], [53], [55], [164], [56], [57]
D1438
 
Salbutamol
 
C13H21NO3
 
2083 
Moderate    Inter Info   
[68], [69], [70]
D1440
 
Salmeterol
 
C25H37NO4
 
5152 
Moderate    Inter Info   
[68], [69], [70]
D1554
 
Terbutaline
 
C12H19NO3
 
5403 
Moderate    Inter Info   
[68], [69], [70]
D1647
 
Trimipramine
 
C20H26N2
 
5584 
Moderate    Inter Info   
[65], [66], [67]
D1695
 
Vilanterol
 
C24H33Cl2NO5
 
10184665 
Moderate    Inter Info   
[68], [69], [70]
D1361
 
Protriptyline
 
C19H21N
 
4976 
Moderate    Inter Info   
[65], [66], [67]
   Additive hypotensive effects Drug Num:  4
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0586
 
Epoprostenol
 
C20H32O5
 
5282411 
Moderate    Inter Info   
[65], [119], [120]
D0792
 
Iloprost
 
C22H32O4
 
5311181 
Moderate    Inter Info   
[65], [119], [120]
D1457
 
Selexipag
 
C26H32N4O4S
 
9913767 
Moderate    Inter Info   
[65], [119], [120]
D1625
 
Treprostinil
 
C23H34O5
 
6918140 
Moderate    Inter Info   
[65], [119], [120]
   Increased risk of hyperpyrexia Drug Num:  7
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0853
 
Isocarboxazid
 
C12H13N3O2
 
3759 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Major    Inter Info   
[58], [59]
D1036
 
Methylene blue
 
C16H18ClN3S
 
6099 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1263
 
Phenelzine
 
C8H12N2
 
3675 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1345
 
Procarbazine
 
C12H19N3O
 
4915 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1455
 
Selegiline
 
C13H17N
 
26757 
Major    Inter Info   
[37], [38], [39], [40], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54], [55], [56], [57]
D1211
 
Ozanimod
 
C23H24N4O3
 
52938427 
Moderate    Inter Info   
[37], [38], [137], [132], [80], [138], [39], [139], [40], [41], [42], [43], [44], [45], [46], [47], [48], [140], [141], [49], [142], [143], [50], [84], [51], [144], [145], [146], [52], [103], [147], [148], [106], [68], [149], [150], [151], [110], [152], [153], [69], [154], [113], [155], [53], [54], [156], [157], [55], [56], [158], [159], [160], [57]
   Increased risk of lowers seizure threshold Drug Num:  10
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0220
 
Bupropion
 
C13H18ClNO
 
444 
Major    Inter Info   
[15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29]
D0833
 
Iohexol
 
C19H26I3N3O9
 
3730 
Major    Inter Info   
[32], [33], [34], [35], [36]
D0834
 
Iopamidol
 
C17H22I3N3O8
 
65492 
Major    Inter Info   
[32], [33], [34], [35], [36]
D1616
 
Tramadol
 
C16H25NO2
 
33741 
Major    Inter Info   
[60], [28], [27], [61]
D0054
 
Amifampridine
 
C5H7N3
 
5918 
Moderate    Inter Info   
[86], [87]
D0722
 
Ginkgo biloba
 
NA
 
NA
Moderate    Inter Info   
[121], [122], [123], [124], [125], [126], [127], [128]
D0932
 
Lindane
 
C6H6Cl6
 
727 
Moderate    Inter Info   
[134], [135], [136]
D1287
 
Picosulfuric acid
 
C18H15NO8S2
 
5243 
Moderate    Inter Info   
[161], [162], [80]
D1308
 
Polyethylene glycol (3350 with electrolytes)
 
C2H6O2
 
174 
Moderate    Inter Info   
[161], [162], [80]
D1488
 
Sodium sulfate
 
Na2O4S
 
24436 
Moderate    Inter Info   
[161], [162], [80]
   Increased risk of ventricular arrhythmias Drug Num:  2
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0491
 
Digoxin
 
C41H64O14
 
2724385 
Moderate    Inter Info   
[71], [72], [73]
D0490
 
Digitoxin
 
C41H64O13
 
441207 
Moderate    Inter Info   
[71], [72], [73]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  5
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0934
 
Liothyronine
 
C15H12I3NO4
 
5920 
Moderate    Inter Info   
[77], [78], [79]
D0918
 
Levodopa
 
C9H11NO4
 
6047 
Moderate    Inter Info   
[132], [80], [133]
D0925
 
Levothyroxine
 
C15H11I4NO4
 
5819 
Moderate    Inter Info   
[77], [78], [79]
D1577
 
Thyroid, porcine
 
NA
 
NA
Moderate    Inter Info   
[77], [78], [79]
D0380
 
Colchicine
 
C22H25NO6
 
6167 
Minor    Inter Info   
[165], [166], [167]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  9
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D1270
 
Phentermine
 
C10H15N
 
4771 
Major    Inter Info   
[9], [10], [11]
D0165
 
Benzphetamine
 
C17H21N
 
5311017 
Major    Inter Info   
[9], [10], [11]
D0457
 
Dexfenfluramine
 
C12H16F3N
 
66265 
Major    Inter Info   
[9], [10], [11]
D0486
 
Diethylpropion
 
C13H19NO
 
7029 
Major    Inter Info   
[9], [10], [11]
D0641
 
Fenfluramine
 
C12H16F3N
 
3337 
Major    Inter Info   
[9], [10], [11]
D0952
 
Lorcaserin
 
C11H14ClN
 
11658860 
Major    Inter Info   
[9], [10], [11]
D0981
 
Mazindol
 
C16H13ClN2O
 
4020 
Major    Inter Info   
[9], [10], [11]
D1012
 
Metamfetamine
 
C10H15N
 
10836 
Major    Inter Info   
[9], [10], [11]
D1262
 
Phendimetrazine
 
C12H17NO
 
30487 
Major    Inter Info   
[9], [10], [11]
      Pharmacodynamic antagonistic effects
   Antagonize the effect of antidiabetic agents Drug Num:  40
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0009
 
Acarbose
 
C25H43NO18
 
41774 
Moderate    Inter Info   
[62], [63], [64]
D0727
 
Glimepiride
 
C24H34N4O5S
 
3476 
Moderate    Inter Info   
[62], [63], [64]
D0811
 
Insulin glargine
 
C267H404N72O78S6
 
118984454 
Moderate    Inter Info   
[62], [63], [64]
D0813
 
Insulin human
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[62], [63], [64]
D0814
 
Insulin human (inhalation, rapid acting)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[62], [63], [64]
D0815
 
Insulin human (isophane)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[62], [63], [64]
D0816
 
Insulin human (regular)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[62], [63], [64]
D0817
 
Insulin human (zinc extended)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[62], [63], [64]
D0818
 
Insulin human (zinc)
 
C257H383N65O77S6
 
118984375 
Moderate    Inter Info   
[62], [63], [64]
D0819
 
Insulin lispro
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[62], [63], [64]
D0820
 
Insulin lispro (protamine)
 
C257H389N65O77S6
 
16132438 
Moderate    Inter Info   
[62], [63], [64]
D1015
 
Metformin
 
C4H11N5
 
4091 
Moderate    Inter Info   
[62], [63], [64]
D0013
 
Acetohexamide
 
C15H20N2O4S
 
1989 
Moderate    Inter Info   
[62], [63], [64]
D0029
 
Albiglutide
 
C148H224N40O45
 
145994868 
Moderate    Inter Info   
[62], [63], [64]
D0042
 
Alogliptin
 
C18H21N5O2
 
11450633 
Moderate    Inter Info   
[62], [63], [64]
D0245
 
Canagliflozin
 
C24H25FO5S
 
24812758 
Moderate    Inter Info   
[62], [63], [64]
D0325
 
Chlorpropamide
 
C10H13ClN2O3S
 
2727 
Moderate    Inter Info   
[62], [63], [64]
D0418
 
Dapagliflozin
 
C21H25ClO6
 
9887712 
Moderate    Inter Info   
[62], [63], [64]
D0565
 
Empagliflozin
 
C23H27ClO7
 
11949646 
Moderate    Inter Info   
[62], [63], [64]
D0728
 
Glipizide
 
C21H27N5O4S
 
3478 
Moderate    Inter Info   
[62], [63], [64]
D0730
 
Glyburide
 
C23H28ClN3O5S
 
3488 
Moderate    Inter Info   
[62], [63], [64]
D0807
 
Insulin aspart (aspart protamine)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[62], [63], [64]
D0808
 
Insulin aspart (aspart)
 
C256H381N65O79S6
 
118984445 
Moderate    Inter Info   
[62], [63], [64]
D0809
 
Insulin degludec
 
C274H411N65O81S6
 
118984462 
Moderate    Inter Info   
[62], [63], [64]
D0810
 
Insulin detemir
 
C267H402N64O76S6
 
16137271 
Moderate    Inter Info   
[62], [63], [64]
D0812
 
Insulin glulisine
 
C258H384N64O78S6
 
16136701 
Moderate    Inter Info   
[62], [63], [64]
D0930
 
Linagliptin
 
C25H28N8O2
 
10096344 
Moderate    Inter Info   
[62], [63], [64]
D0936
 
Liraglutide
 
C172H265N43O51
 
16134956 
Moderate    Inter Info   
[62], [63], [64]
D0941
 
Lixisenatide
 
C215H347N61O65S
 
90472060 
Moderate    Inter Info   
[62], [63], [64]
D1064
 
Miglitol
 
C8H17NO5
 
441314 
Moderate    Inter Info   
[62], [63], [64]
D1112
 
Nateglinide
 
C19H27NO3
 
5311309 
Moderate    Inter Info   
[62], [63], [64]
D1294
 
Pioglitazone
 
C19H20N2O3S
 
4829 
Moderate    Inter Info   
[62], [63], [64]
D1326
 
Pramlintide
 
C171H267N51O53S2
 
70691388 
Moderate    Inter Info   
[62], [63], [64]
D1392
 
Repaglinide
 
C27H36N2O4
 
65981 
Moderate    Inter Info   
[62], [63], [64]
D1429
 
Rosiglitazone
 
C18H19N3O3S
 
77999 
Moderate    Inter Info   
[62], [63], [64]
D1449
 
Saxagliptin
 
C18H25N3O2
 
11243969 
Moderate    Inter Info   
[62], [63], [64]
D1477
 
Sitagliptin
 
C16H15F6N5O
 
4369359 
Moderate    Inter Info   
[62], [63], [64]
D1601
 
Tolazamide
 
C14H21N3O3S
 
5503 
Moderate    Inter Info   
[62], [63], [64]
D1603
 
Tolbutamide
 
C12H18N2O3S
 
5505 
Moderate    Inter Info   
[62], [63], [64]
D1652
 
Troglitazone
 
C24H27NO5S
 
5591 
Moderate    Inter Info   
[62], [63], [64]
   Antagonize the effect of antihypertensive agents Drug Num:  7
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0743
 
Guanadrel
 
C10H19N3O2
 
38521 
Moderate    Inter Info   
[74], [75], [76]
D0444
 
Deserpidine
 
C32H38N2O8
 
8550 
Moderate    Inter Info   
[74], [75], [76]
D1779
 
Dulaglutide
 
NA
 
NA
Moderate    Inter Info   
[62], [63], [64]
D1784
 
Exenatide
 
C184H282N50O60S
 
45588096 
Moderate    Inter Info   
[62], [63], [64]
D0744
 
Guanethidine
 
C10H22N4
 
3518 
Moderate    Inter Info   
[74], [75], [76]
D1887
 
Semaglutide
 
C187H291N45O59
 
56843331 
Moderate    Inter Info   
[62], [63], [64]
D1393
 
Reserpine
 
C33H40N2O9
 
5770 
Moderate    Inter Info   
[74], [75], [76]
   Antagonize the effect of dopaminergic agents Drug Num:  13
Drug ID
 
Drug Name
Formula Pubchem ID Severity Level Interaction Detail REF
D0037
 
Alimemazine
 
C18H22N2S
 
5574 
Moderate    Inter Info   
[83], [84], [85]
D0324
 
Chlorpromazine
 
C17H19ClN2S
 
2726 
Moderate    Inter Info   
[88], [89], [90], [91], [92], [93], [94], [95], [96], [83], [97], [98], [84], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [68], [109], [110], [111], [112], [113], [85], [114], [115], [116], [117]
D0678
 
Fluphenazine
 
C22H26F3N3OS
 
3372 
Moderate    Inter Info   
[88], [89], [90], [91], [92], [93], [94], [95], [96], [83], [97], [98], [84], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [68], [109], [110], [111], [112], [113], [85], [114], [115], [116], [117]
D0750
 
Haloperidol
 
C21H23ClFNO2
 
3559 
Moderate    Inter Info   
[88], [89], [129], [90], [92], [93], [94], [95], [96], [83], [97], [98], [99], [100], [101], [102], [103], [113], [85], [114], [115], [116], [117]
D1010
 
Mesoridazine
 
C21H26N2OS2
 
4078 
Moderate    Inter Info   
[83], [84], [85]
D1019
 
Methdilazine
 
C18H20N2S
 
14677 
Moderate    Inter Info   
[83], [84], [85]
D1026
 
Methotrimeprazine
 
C19H24N2OS
 
72287 
Moderate    Inter Info   
[83], [84], [85]
D1257
 
Perphenazine
 
C21H26ClN3OS
 
4748 
Moderate    Inter Info   
[88], [89], [90], [91], [92], [93], [94], [95], [96], [83], [97], [98], [84], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [68], [109], [110], [111], [112], [113], [85], [114], [115], [116], [117]
D1346
 
Prochlorperazine
 
C20H24ClN3S
 
4917 
Moderate    Inter Info   
[88], [89], [90], [91], [92], [93], [94], [95], [96], [83], [97], [98], [84], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [68], [109], [110], [111], [112], [113], [85], [114], [115], [116], [117]
D1352
 
Promethazine
 
C17H20N2S
 
4927 
Moderate    Inter Info   
[88], [89], [90], [91], [92], [93], [94], [95], [96], [83], [97], [98], [84], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [68], [109], [110], [111], [112], [113], [85], [114], [115], [116], [117]
D1574
 
Thioridazine
 
C21H26N2S2
 
5452 
Moderate    Inter Info   
[83], [84], [85]
D1637
 
Trifluoperazine
 
C21H24F3N3S
 
5566 
Moderate    Inter Info   
[88], [89], [90], [91], [92], [93], [94], [95], [96], [83], [97], [98], [84], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [68], [109], [110], [111], [112], [113], [85], [114], [115], [116], [117]
D1572
 
Thiethylperazine
 
C22H29N3S2
 
5440 
Moderate    Inter Info   
[83], [84], [85]
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147 Product Information. Aldomet (methyldopa). Merck & Co, Inc, West Point, PA.
148 Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
149 Product Information. Iopidine (apraclonidine). Alcon Laboratories Inc, Fort Worth, TX.
150 Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
151 Product Information. Parcopa (carbidopa-levodopa). Schwarz Pharma, Mequon, WI.
152 Product Information. Sinemet (carbidopa-levodopa). DuPont Pharmaceuticals, Wilmington, DE.
153 Product Information. Stalevo 50 (carbidopa/entacapone/levodopa). Novartis Pharmaceuticals, East Hanover, NJ.
154 Product Information. Tyzine (tetrahydrozoline). Kenwood Laboratories, Fairfield, NJ.
155 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.
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161 Product Information. Suprep Bowel Prep Kit (magnesium/potassium/sodium sulfates). Braintree Laboratories, Braintree, MA.
162 Salik JM, Kurtin P "Severe hyponatremia after colonoscopy preparation in a patient with the acquired immune deficiency syndrome." Am J Gastroenterol 80 (1985): 177-9. [PMID: 2983533]
163 Product Information. Azilect (rasagiline). Teva Pharmaceuticals USA, North Wales, PA.
164 Smookler S, Barmudez AJ "Hypertensive crisis resulting from an MAO inhibitor and an over-the counter appetite suppressant." Ann Emerg Med 11 (1982): 482-4. [PMID: 7114595]
165 Akdag I, Ersoy A, Kahvecioglu S, Gullulu M, Dilek K "Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure." J Nephrol 19 (2006): 515-7. [PMID: 17048210]
166 Goldbart A, Press J, Sofer S, Kapelushnik J "Near fatal acute colchicine intoxication in a child. A case report." Eur J Pediatr 159 (2000): 895-7. [PMID: 11131346]
167 Product Information. Colchicine (colchicine). Lilly, Eli and Company, Indianapolis, IN.