Drug General Information (ID: DDIPY3QZ5W)
Drug Name			Phenylpropanolamine		Drug Info		Droxidopa		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Appetite Depressants				Vasopressors
Structure

Mechanism of Phenylpropanolamine-Droxidopa Interaction (Severity Level: Moderate)
Additive hypertensive effects Click to Show/Hide Mechanism Graph
Drug Name		Phenylpropanolamine				Droxidopa
Mechanism		Hypertensive effects				Hypertensive effects
Key Mechanism Factor 1
		Factor Name		Hypertensive effects
		Factor Description		Hypertension is defined as a blood pressure reading above a prescribed limit (130/90 mmHg). Most people with hypertension have no signs or symptoms; others may experience: severe headache, shortness of breath, nosebleeds, severe anxiety, and feeling a tingling sensation in the neck or head.
Mechanism Description		Additive hypertensive effects by the combination of Phenylpropanolamine and Droxidopa

Recommended Action
Management		Supine blood pressure should be monitored prior to and during droxidopa treatment, and more frequently when increasing dosage. Patients should elevate the head of the bed when resting or sleeping, and have blood pressure also measured in this position. Dosage reduction or discontinuation of droxidopa is recommended if supine hypertension cannot be managed by elevation of the head of the bed. Supine hypertension that is not well managed may increase the risk of cardiovascular events, particularly stroke.

References
1	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.