Details of Drug

Drug General Information (ID: D0538)
Drug Name	Droxidopa
Drug Type	Small molecule
Drug Synonymous	droxidopa; 23651-95-8; L-DOPS; Northera; (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid; threo-Dopaserine; 3916-18-5; DOPS; DL-threo-DOPS; L-Threodops; DL-threo-3,4-Dihydroxyphenylserine; DL-threo-Droxidopa; DL-threo-Dihydroxyphenylserine; UNII-J7A92W69L7; SM 5688; CHEBI:31524; Droxidopa (L-DOPS); threo-beta,3-Dihydroxy-DL-tyrosine; EINECS 223-480-5; beta,3-Dihydroxy-DL-tyrosine threo-; BRN 2852792; L-threo-dihydroxyphenylserine; DL-threo-3-(3,4-Dihydroxyphenyl)serine; Serine, 3-(3,4-dihydroxyphenyl)-, DL-threo- Click to Show/Hide
Disease Class	8D87: Autonomic nervous system disorder
Therapeutic Class	Vasopressors
Structure
Structure	3D Structure		2D Structure
Formula	C9H11NO5
InChI	1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
InChIKey	QXWYKJLNLSIPIN-JGVFFNPUSA-N
Canonical SMILES	C1=CC(=C(C=C1C(C(C(=O)O)N)O)O)O
External Link
	Pubchem ID	92974
	CAS Number	23651-95-8
	CHEBI ID	31524
	TTD ID	D0I3RO
	INTEDE ID	DR0552

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM041 Additive hypertensive effects BM078 Increased risk of rapid heart rate BM107 Attenuated pharmacological effects (Unspecific)
Relation Graph

Full list of drugs interacting with Droxidopa
Pharmacodynamic additive effects
	Additive hypertensive effects					Drug Num: 63
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0377		Cocaine (nasal)	C17H21NO4	446220	Major		Inter Info	[1], [2], [3]
D0378		Cocaine (topical)	C17H21NO4	446220	Major		Inter Info	[1], [2], [3]
D0041		Almotriptan	C17H25N3O2S	123606	Moderate		Inter Info	[4]
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[4]
D0103		Arformoterol	C19H24N2O4	3083544	Moderate		Inter Info	[4]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[4]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[4]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[4]
D0510		Dobutamine	C18H23NO3	36811	Moderate		Inter Info	[4]
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[4]
D0778		Hydroxyamphetamine (ophthalmic)	C9H13NO	3651	Moderate		Inter Info	[4]
D0857		Isometheptene	C9H19N	22297	Moderate		Inter Info	[4]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[4]
D0924		Levosalbutamol	C13H21NO3	123600	Moderate		Inter Info	[4]
D1036		Methylene blue	C16H18ClN3S	6099	Moderate		Inter Info	[4]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[5], [6], [4]
D1374		Racepinephrine	C9H13NO3	838	Moderate		Inter Info	[4]
D1492		Solriamfetol	C10H14N2O2	10130337	Moderate		Inter Info	[7]
D1695		Vilanterol	C24H33Cl2NO5	10184665	Moderate		Inter Info	[4]
D0557		Eletriptan	C22H26N2O2S	77993	Moderate		Inter Info	[4]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[4]
D0580		Ephedrine (nasal)	C10H15NO	9294	Moderate		Inter Info	[4]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[4]
D0582		Epinephrine (ophthalmic)	C9H13NO3	5816	Moderate		Inter Info	[4]
D0583		Epinephrine (topical)	C9H13NO3	5816	Moderate		Inter Info	[4]
D0641		Fenfluramine	C12H16F3N	3337	Moderate		Inter Info	[4]
D0691		Formoterol	C19H24N2O4	3410	Moderate		Inter Info	[4]
D0702		Frovatriptan	C14H17N3O	77992	Moderate		Inter Info	[4]
D0797		Indacaterol	C24H28N2O3	6918554	Moderate		Inter Info	[4]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[4]
D0854		Isoetharine	C13H21NO3	3762	Moderate		Inter Info	[4]
D0859		Isoprenaline	C11H17NO3	3779	Moderate		Inter Info	[4]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[4]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[4]
D0981		Mazindol	C16H13ClN2O	4020	Moderate		Inter Info	[4]
D1002		Mephentermine	C11H17N	3677	Moderate		Inter Info	[4]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[4]
D1013		Metaraminol	C9H13NO2	5906	Moderate		Inter Info	[4]
D1027		Methoxamine	C11H17NO3	6082	Moderate		Inter Info	[4]
D1061		Midodrine	C12H18N2O4	4195	Moderate		Inter Info	[4]
D1110		Naratriptan	C17H25N3O2S	4440	Moderate		Inter Info	[4]
D1153		Norepinephrine	C8H11NO3	439260	Moderate		Inter Info	[4]
D1185		Orciprenaline	C11H17NO3	4086	Moderate		Inter Info	[4]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[4]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[4]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[4]
D1276		Phenylephrine	C9H13NO2	6041	Moderate		Inter Info	[4]
D1277		Phenylephrine (nasal)	C9H13NO2	6041	Moderate		Inter Info	[4]
D1278		Phenylephrine (ophthalmic)	C9H13NO2	6041	Moderate		Inter Info	[4]
D1279		Phenylephrine (otic)	C9H13NO2	6041	Moderate		Inter Info	[4]
D1280		Phenylephrine (topical)	C9H13NO2	6041	Moderate		Inter Info	[4]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[4]
D1298		Pirbuterol	C12H20N2O3	4845	Moderate		Inter Info	[4]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[4]
D1363		Pseudoephedrine	C10H15NO	7028	Moderate		Inter Info	[4]
D1414		Ritodrine	C17H21NO3	33572	Moderate		Inter Info	[4]
D1419		Rizatriptan	C15H19N5	5078	Moderate		Inter Info	[4]
D1438		Salbutamol	C13H21NO3	2083	Moderate		Inter Info	[4]
D1440		Salmeterol	C25H37NO4	5152	Moderate		Inter Info	[4]
D1521		Sumatriptan	C14H21N3O2S	5358	Moderate		Inter Info	[4]
D1554		Terbutaline	C12H19NO3	5403	Moderate		Inter Info	[4]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[4]
D1728		Zolmitriptan	C16H21N3O2	60857	Moderate		Inter Info	[4]
Pharmacodynamic antagonistic effects
	Attenuated pharmacological effects (Unspecific)					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0258		Carbidopa	C10H14N2O4	34359	Moderate		Inter Info	[4]

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Thevasagyam M, Jindal M, Allsop P, Oates J "Does epinephrine infiltration in septoplasty make any difference?" Eur Arch Otorhinolaryngol 264 (2007): 1175-8.[PMID: 17530270]
3	Product Information. Cocaine Hydrochloride (cocaine topical). Mallinckrodt Medical Inc, St. Louis, MO.
4	Product Information. Northera (droxidopa). Chelsea Therapeutics Inc, Charlotte, NC.
5	Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
6	Product Information. Marplan (isocarboxazid) Roche Laboratories, Nutley, NJ.
7	Product Information. Sunosi (solriamfetol). Jazz Pharmaceuticals, Palo Alto, CA.

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