Drug General Information (ID: DDISL39ZQV)
  Drug Name Phenylpropanolamine Drug Info Colchicine Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Appetite Depressants Antigout Agents
  Structure

 Mechanism of Phenylpropanolamine-Colchicine Interaction (Severity Level: Minor)
     Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
      Drug Name Phenylpropanolamine Colchicine
      Mechanism Sympathomimetic amine Potentiate the pharmacologic effects of sympathomimetic amine
      Key Mechanism Factor 1
Factor Name Pharmacodynamics
Factor Description Enhanced pharmacological effects leading to increased adverse reactions.
      Mechanism Description
  • Potentiate the pharmacologic effects by the combination of Phenylpropanolamine and Colchicine 

References
1 Akdag I, Ersoy A, Kahvecioglu S, Gullulu M, Dilek K "Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure." J Nephrol 19 (2006): 515-7. [PMID: 17048210]
2 Goldbart A, Press J, Sofer S, Kapelushnik J "Near fatal acute colchicine intoxication in a child. A case report." Eur J Pediatr 159 (2000): 895-7. [PMID: 11131346]
3 Product Information. Colchicine (colchicine). Lilly, Eli and Company, Indianapolis, IN.