Details of Drug

Details of Drug

 Drug General Information (ID: D0380)
  Drug Name
Colchicine
  Drug Type Small molecule
  Drug Synonymous
Colchicin; Colchicina; Colchicinum; Colchineos; Colchisol; Colchysat; Colcin; Colcrys; Colsaloid; Colstat; Condylon; Goutnil; Kolkicin; LOC; Binds to tubulin; Colchicin [German]; Colchicina [Italian]; Colchicine [JAN]; Inhibits microtubular assembly; Spindle poison; C 9754; Colchicine (TN); Colchicine, Colchicum autumnale; MPC-004; N-Acetyl trimethylcolchicinic acid methylether; Colchicine (JP15/USP); Colchicine, (R)-Isomer; Benzo(a)heptalen-9(5H)-one; Colchicine, (+-)-Isomer; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide; N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-acetamide; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; 7-alpha-H-Colchicine; 7.alpha.H-Colchicine; 7alphaH-Colchicine
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  Disease Class FA25: Gout
  Therapeutic Class Antigout Agents
  Structure Could Not Find 2D Structure
3D Structure 2D Structure
  Formula C22H25NO6
  InChI 1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
  InChIKey IAKHMKGGTNLKSZ-INIZCTEOSA-N
  Canonical SMILES CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC
  External Link
Pubchem ID 6167
CAS Number 64-86-8
CHEBI ID 27882
TTD ID D09DHY
INTEDE ID DR0372
VARIDT ID DR00135

Drug-Drug Interaction Network
  Sunburst Graph
AM002  Affected cellular transport
AM004  Affected intra/extra-hepatic metabolism
AM006  Pharmacodynamic additive effects
BM010  Transporter inhibition
BM011  Transporter induction
BM012  Competitive inhibition of transporters
BM017  CYP450 enzyme inhibition
BM022  CYP450 enzyme induction
BM024  Competitive inhibition of metabolic enzyme
BM043  Additive immunosuppressive effects
BM044  Additive myelosuppressive effects
BM074  Increased risk of peripheral neuropathy
BM083  Potentiated the pharmacological effects (Unspecific)
BM109  Increased risk of other adverse reactions (Unspecific)
  Relation Graph
 Full list of drugs interacting with Colchicine
      Affected cellular transport
   Transporter inhibition Drug Num:  42
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0066
 
Amiodarone
 
C25H29I2NO3
 
2157 
Major    Inter Info   
[1], [2], [3]
D0139
 
Azithromycin
 
C38H72N2O12
 
447043 
Major    Inter Info   
[1], [2], [3]
D0170
 
Bepridil
 
C24H34N2O
 
2351 
Major    Inter Info   
[1], [2], [3]
D0267
 
Carvedilol
 
C24H26N2O4
 
2585 
Major    Inter Info   
[1], [2], [3]
D0251
 
Capmatinib
 
C23H17FN6O
 
25145656 
Major    Inter Info   
[1], [2], [3]
D0408
 
Daclatasvir
 
C40H50N8O6
 
25154714 
Major    Inter Info   
[1], [2], [3]
D0559
 
Eliglustat
 
C23H36N2O4
 
23652731 
Major    Inter Info   
[1], [2], [3]
D0665
 
Flibanserin
 
C20H21F3N4O
 
6918248 
Major    Inter Info   
[1], [2], [3]
D0720
 
Gilteritinib
 
C29H44N8O3
 
49803313 
Major    Inter Info   
[1], [2], [3]
D0726
 
Glecaprevir
 
C38H46F4N6O9S
 
66828839 
Major    Inter Info   
[1], [2], [3]
D0866
 
Istradefylline
 
C20H24N4O4
 
5311037 
Major    Inter Info   
[1], [2], [3]
D0869
 
Ivacaftor
 
C24H28N2O3
 
16220172 
Major    Inter Info   
[1], [2], [3]
D0897
 
Lasmiditan
 
C19H18F3N3O2
 
11610526 
Major    Inter Info   
[1], [2], [3]
D0898
 
Ledipasvir
 
C49H54F2N8O6
 
67505836 
Major    Inter Info   
[1], [2], [3]
D0944
 
Lomitapide
 
C39H37F6N3O2
 
9853053 
Major    Inter Info   
[1], [2], [3]
D1062
 
Midostaurin
 
C35H30N4O4
 
9829523 
Major    Inter Info   
[1], [2], [3]
D1124
 
Neratinib
 
C30H29ClN6O3
 
9915743 
Major    Inter Info   
[1], [2], [3]
D1136
 
Nilotinib
 
C28H22F3N7O
 
644241 
Major    Inter Info   
[1], [2], [3]
D1313
 
Ponatinib
 
C29H27F3N6O
 
24826799 
Major    Inter Info   
[1], [2], [3]
D1423
 
Rolapitant
 
C25H26F6N2O2
 
10311306 
Major    Inter Info   
[1], [2], [3]
D1445
 
Sarecycline
 
C24H29N3O8
 
54681908 
Major    Inter Info   
[1], [2], [3]
D1524
 
Suvorexant
 
C23H23ClN6O2
 
24965990 
Major    Inter Info   
[1], [2], [3]
D1664
 
Ulipristal
 
C28H35NO3
 
13559281 
Major    Inter Info   
[1], [2], [3]
D1686
 
Velpatasvir
 
C49H54N8O8
 
67683363 
Major    Inter Info   
[1], [2], [3]
D1687
 
Vemurafenib
 
C23H18ClF2N3O3S
 
42611257 
Major    Inter Info   
[1], [2], [3]
D1688
 
Venetoclax
 
C45H50ClN7O7S
 
49846579 
Major    Inter Info   
[1], [2], [3]
D0894
 
Lapatinib
 
C29H26ClFN4O4S
 
208908 
Major    Inter Info   
[1], [2], [3]
D1353
 
Propafenone
 
C21H27NO3
 
4932 
Major    Inter Info   
[1], [2], [3]
D1371
 
Quinidine
 
C20H24N2O2
 
441074 
Major    Inter Info   
[1], [2], [3]
D1372
 
Quinine
 
C20H24N2O2
 
3034034 
Major    Inter Info   
[1], [2], [3]
D1497
 
Sorafenib
 
C21H16ClF3N4O3
 
216239 
Major    Inter Info   
[1], [2], [3]
D1501
 
Spironolactone
 
C24H32O4S
 
5833 
Major    Inter Info   
[1], [2], [3]
D1526
 
Tacrolimus
 
C44H69NO12
 
445643 
Major    Inter Info   
[1], [2], [3]
D1533
 
Tamoxifen
 
C26H29NO
 
2733526 
Major    Inter Info   
[1], [2], [3]
D0044
 
Alpelisib
 
C19H22F3N5O2S
 
56649450 
Moderate    Inter Info   
[22], [63], [64]
D0204
 
Brigatinib
 
C29H39ClN7O2P
 
68165256 
Moderate    Inter Info   
[22], [69], [70]
D0261
 
Carfilzomib
 
C40H57N5O7
 
11556711 
Moderate    Inter Info   
[22]
D0590
 
Erdafitinib
 
C25H30N6O2
 
67462786 
Moderate    Inter Info   
[77]
D0785
 
Ibrutinib
 
C25H24N6O2
 
24821094 
Moderate    Inter Info   
[22], [80]
D1167
 
Olaparib
 
C24H23FN4O3
 
23725625 
Moderate    Inter Info   
[21], [22]
D1608
 
Tolvaptan
 
C26H25ClN2O3
 
216237 
Moderate    Inter Info   
[21], [22], [96], [97]
D0491
 
Digoxin
 
C41H64O14
 
2724385 
Moderate    Inter Info   
[12]
      Affected intra/extra-hepatic metabolism
   CYP450 enzyme inhibition Drug Num:  56
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0080
 
Amprenavir
 
C25H35N3O6S
 
65016 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0100
 
Aprepitant
 
C23H21F7N4O3
 
135413536 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0116
 
Atazanavir
 
C38H52N6O7
 
148192 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0341
 
Ciprofloxacin
 
C17H18FN3O3
 
2764 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0349
 
Clarithromycin
 
C38H69NO13
 
84029 
Major    Inter Info   
[4], [5], [21], [22], [7], [23], [8], [9], [10], [11], [30], [24], [12], [25], [27], [14], [15], [16], [17], [18], [19], [20]
D0171
 
Berotralstat
 
C30H26F4N6O
 
137528262 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0192
 
Boceprevir
 
C27H45N5O5
 
10324367 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0302
 
Ceritinib
 
C28H36ClN5O3S
 
57379345 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0375
 
Cobicistat
 
C40H53N7O5S2
 
25151504 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0413
 
Dalfopristin
 
C34H50N4O9S
 
6323289 
Major    Inter Info   
[9], [17], [18]
D0534
 
Dronedarone
 
C31H44N2O5S
 
208898 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0543
 
Duvelisib
 
C22H17ClN6O
 
50905713 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0693
 
Fosaprepitant
 
C23H22F7N4O6P
 
135413538 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0696
 
Fosnetupitant
 
C31H35F6N4O5P
 
71544786 
Major    Inter Info   
[9], [17], [18]
D0789
 
Idelalisib
 
C22H18FN7O
 
11625818 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0852
 
Isavuconazonium
 
C35H35F2N8O5S+
 
6918606 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0906
 
Letermovir
 
C29H28F4N4O4
 
45138674 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0946
 
Lonafarnib
 
C27H31Br2ClN4O2
 
148195 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D1127
 
Netupitant
 
C30H32F6N4O
 
6451149 
Major    Inter Info   
[9], [17], [18]
D1398
 
Ribociclib
 
C23H30N8O
 
44631912 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1505
 
Stiripentol
 
C14H18O3
 
5311454 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1541
 
Telaprevir
 
C36H53N7O6
 
3010818 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D1660
 
Tucatinib
 
C26H24N8O2
 
51039094 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D1709
 
Voxelotor
 
C19H19N3O3
 
71602803 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0386
 
Conivaptan
 
C32H26N4O2
 
151171 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0426
 
Darunavir
 
C27H37N3O7S
 
213039 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0439
 
Delavirdine
 
C22H28N6O3S
 
5625 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0497
 
Diltiazem
 
C22H26N2O4S
 
39186 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0597
 
Erythromycin
 
C37H67NO13
 
12560 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0667
 
Fluconazole
 
C13H12F2N6O
 
3365 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0692
 
Fosamprenavir
 
C25H36N3O9PS
 
131536 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0793
 
Imatinib
 
C29H31N7O
 
5291 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D0799
 
Indinavir
 
C36H47N5O4
 
5362440 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0867
 
Itraconazole
 
C35H38Cl2N8O4
 
55283 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0880
 
Ketoconazole
 
C26H28Cl2N4O4
 
456201 
Major    Inter Info   
[8], [12], [52]
D1117
 
Nefazodone
 
C25H32ClN5O2
 
4449 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D1119
 
Nelfinavir
 
C32H45N3O4S
 
64143 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D1315
 
Posaconazole
 
C37H42F2N8O4
 
468595 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1415
 
Ritonavir
 
C37H48N6O5S2
 
392622 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D1444
 
Saquinavir
 
C38H50N6O5
 
441243 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D1544
 
Telithromycin
 
C43H65N5O10
 
3002190 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D1690
 
Verapamil
 
C27H38N2O4
 
2520 
Major    Inter Info   
[4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
D1706
 
Voriconazole
 
C16H14F3N5O
 
71616 
Major    Inter Info   
[4], [5], [6], [21], [22], [7], [23], [8], [9], [10], [11], [24], [12], [25], [26], [27], [14], [15], [16], [17], [18], [19], [20]
D0337
 
Cimetidine
 
C10H16N6S
 
2756 
Moderate    Inter Info   
[60], [61]
D0002
 
Abametapir (topical)
 
C12H12N2
 
15664 
Moderate    Inter Info   
[62]
D0191
 
Blinatumomab
 
NA
 
NA
Moderate    Inter Info   
[66]
D0432
 
Deferasirox
 
C21H15N3O4
 
214348 
Moderate    Inter Info   
[71], [72]
D0577
 
Entrectinib
 
C31H34F2N6O2
 
25141092 
Moderate    Inter Info   
[74]
D0699
 
Fostamatinib
 
C23H26FN6O9P
 
11671467 
Moderate    Inter Info   
[79]
D0896
 
Larotrectinib
 
C21H22F2N6O2
 
46188928 
Moderate    Inter Info   
[21], [22], [82]
D0899
 
Lefamulin
 
C28H45NO5S
 
25185057 
Moderate    Inter Info   
[83]
D1214
 
Palbociclib
 
C24H29N7O2
 
5330286 
Moderate    Inter Info   
[87]
D1459
 
Selpercatinib
 
C29H31N7O3
 
134436906 
Moderate    Inter Info   
[22], [89]
D1579
 
Ticagrelor
 
C23H28F2N6O4S
 
9871419 
Moderate    Inter Info   
[22], [95]
D0428
 
Dasatinib
 
C22H26ClN7O2S
 
3062316 
Moderate    Inter Info   
[101]
D1057
 
Miconazole
 
C18H14Cl4N2O
 
4189 
Moderate    Inter Info   
[103]
   CYP450 enzyme induction Drug Num:  14
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0095
 
Apalutamide
 
C21H15F4N5O2S
 
24872560 
Moderate    Inter Info   
[22], [65]
D0545
 
Echinacea
 
NA
 
NA
Moderate    Inter Info   
[21], [73]
D0578
 
Enzalutamide
 
C21H16F4N4O2S
 
15951529 
Moderate    Inter Info   
[75], [21], [22], [76]
D0628
 
Etravirine
 
C20H15BrN6O
 
193962 
Moderate    Inter Info   
[78]
D0872
 
Ivosidenib
 
C28H22ClF3N6O3
 
71657455 
Moderate    Inter Info   
[81]
D0953
 
Lorlatinib
 
C21H19FN6O2
 
71731823 
Moderate    Inter Info   
[84]
D1190
 
Osimertinib
 
C28H33N7O2
 
71496458 
Moderate    Inter Info   
[22], [86]
D1493
 
Somapacitan
 
C54H95N13O20S2
 
129894493 
Moderate    Inter Info   
[21], [22], [90]
D1495
 
Somatrem
 
C43H72N14O14
 
5487805 
Moderate    Inter Info   
[21], [22], [91], [90]
D0554
 
Efavirenz
 
C14H9ClF3NO2
 
64139 
Moderate    Inter Info   
[102]
D1401
 
Rifapentine
 
C47H64N4O12
 
135403821 
Moderate    Inter Info   
[104], [105]
D1494
 
Somatotropin
 
NA
 
NA
Moderate    Inter Info   
[21], [22], [90]
D0106
 
Armodafinil
 
C15H15NO2S
 
9690109 
Minor    Inter Info   
[109], [110], [111], [112], [113]
D1081
 
Modafinil
 
C15H15NO2S
 
4236 
Minor    Inter Info   
[109], [110], [111], [112], [113]
   Competitive inhibition of metabolic enzyme Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0402
 
Cyclosporine
 
C62H111N11O12
 
5284373 
Major    Inter Info   
[35], [36], [22], [8], [37], [38], [39], [40], [41], [1], [42], [2], [3], [43], [44], [45], [12], [46], [47], [48], [49], [50], [20], [51]
D1549
 
Temsirolimus
 
C56H87NO16
 
6918289 
Moderate    Inter Info   
[93], [94]
D1476
 
Sirolimus
 
C51H79NO13
 
5284616 
Moderate    Inter Info   
[93], [94]
      Pharmacodynamic additive effects
   Additive immunosuppressive effects Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D1375
 
Radium Ra 223 dichloride
 
NA
 
NA
Moderate    Inter Info   
[88]
D1509
 
Strontium chloride Sr-89
 
Cl2Sr
 
5388879 
Moderate    Inter Info   
[21], [22], [92]
D1671
 
Ustekinumab
 
NA
 
NA
Moderate    Inter Info   
[98]
   Additive myelosuppressive effects Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0348
 
Cladribine
 
C10H12ClN5O3
 
20279 
Major    Inter Info   
[22], [29]
D0370
 
Clozapine
 
C18H19ClN4
 
135398737 
Major    Inter Info   
[22], [31], [32]
D0433
 
Deferiprone
 
C7H9NO2
 
2972 
Major    Inter Info   
[21], [33], [34]
D0033
 
Alemtuzumab
 
NA
 
NA
Moderate    Inter Info   
[53]
D0136
 
Azathioprine
 
C9H7N7O2S
 
2265 
Moderate    Inter Info   
[21], [22]
D1174
 
Omacetaxine mepesuccinate
 
C29H39NO9
 
285033 
Moderate    Inter Info   
[85]
D1676
 
Valganciclovir
 
C14H22N6O5
 
135413535 
Moderate    Inter Info   
[21], [22], [99], [100]
D0710
 
Ganciclovir
 
C9H13N5O4
 
135398740 
Moderate    Inter Info   
[21], [22], [99], [100]
   Increased risk of peripheral neuropathy Drug Num:  63
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0126
 
Auranofin
 
C20H34AuO9PS
 
24199313 
Moderate    Inter Info   
[54], [55], [56]
D0193
 
Bortezomib
 
C19H25BN4O4
 
387447 
Moderate    Inter Info   
[57], [58], [59]
D0260
 
Carboplatin
 
C6H12N2O4Pt
 
426756 
Moderate    Inter Info   
[54], [55], [56]
D0313
 
Chloramphenicol
 
C11H12Cl2N2O5
 
5959 
Moderate    Inter Info   
[54], [55], [56]
D0320
 
Chloroquine
 
C18H26ClN3
 
2719 
Moderate    Inter Info   
[54], [55], [56]
D0344
 
Cisplatin
 
Cl2H6N2Pt
 
5702198 
Moderate    Inter Info   
[54], [55], [56]
D0127
 
Aurothioglucose
 
C6H11AuO5S
 
454937 
Moderate    Inter Info   
[54], [55], [56]
D0162
 
Benznidazole
 
C12H12N4O3
 
31593 
Moderate    Inter Info   
[54], [55], [56]
D0199
 
Brentuximab vedotin
 
NA
 
NA
Moderate    Inter Info   
[54], [67], [68]
D0227
 
Cabazitaxel
 
C45H57NO14
 
9854073 
Moderate    Inter Info   
[54], [55], [56]
D0304
 
Certolizumab pegol
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0496
 
Diiodohydroxyquinoline
 
C9H5I2NO
 
3728 
Moderate    Inter Info   
[54], [55], [56]
D0560
 
Elotuzumab
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0594
 
Eribulin
 
C40H59NO11
 
11354606 
Moderate    Inter Info   
[54], [55], [56]
D0736
 
Golimumab
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0841
 
Ipilimumab
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0873
 
Ixabepilone
 
C27H42N2O5S
 
6445540 
Moderate    Inter Info   
[54], [55], [56]
D0874
 
Ixazomib
 
C14H19BCl2N2O4
 
25183872 
Moderate    Inter Info   
[54], [55], [56]
D1113
 
Naxitamab
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D1306
 
Polatuzumab vedotin
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D1312
 
Pomalidomide
 
C13H11N3O4
 
134780 
Moderate    Inter Info   
[54], [55], [56]
D1452
 
Secnidazole
 
C7H11N3O3
 
71815 
Moderate    Inter Info   
[54], [55], [56]
D1479
 
Sodium aurothiomalate
 
C4H3AuNa2O4S
 
22318 
Moderate    Inter Info   
[54], [55], [56]
D1556
 
Teriflunomide
 
C12H9F3N2O2
 
54684141 
Moderate    Inter Info   
[54], [55], [56]
D1599
 
Tocilizumab
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D1615
 
Trabectedin
 
C39H43N3O11S
 
108150 
Moderate    Inter Info   
[54], [55], [56]
D1623
 
Trastuzumab emtansine
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0419
 
Dapsone
 
C12H12N2O2S
 
2955 
Moderate    Inter Info   
[54], [55], [56]
D0483
 
Didanosine
 
C10H12N4O3
 
135398739 
Moderate    Inter Info   
[54], [55], [56]
D0509
 
Disulfiram
 
C10H20N2S4
 
3117 
Moderate    Inter Info   
[54], [55], [56]
D0511
 
Docetaxel
 
C43H53NO14
 
148124 
Moderate    Inter Info   
[54], [55], [56]
D0614
 
Etanercept
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D1731
 
Ethionamide
 
C8H10N2S
 
2761171 
Moderate    Inter Info   
[54], [55], [56]
D0627
 
Etoposide
 
C29H32O13
 
36462 
Moderate    Inter Info   
[54], [55], [56]
D0669
 
Fludarabine
 
C10H12FN5O4
 
657237 
Moderate    Inter Info   
[54], [55], [56]
D0770
 
Hydralazine
 
C8H8N4
 
3637 
Moderate    Inter Info   
[54], [55], [56]
D0802
 
Infliximab
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0821
 
Interferon alfa-2a, Recombinant
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0822
 
Interferon alfa-2b
 
C16H17Cl3I2N3NaO5S
 
71306834 
Moderate    Inter Info   
[54], [55], [56]
D0824
 
Interferon alfa-n1
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0823
 
Interferon alfacon-1
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D0858
 
Isoniazid
 
C6H7N3O
 
3767 
Moderate    Inter Info   
[54], [55], [56]
D0900
 
Leflunomide
 
C12H9F3N2O2
 
3899 
Moderate    Inter Info   
[54], [55], [56]
D0918
 
Levodopa
 
C9H11NO4
 
6047 
Moderate    Inter Info   
[54], [55], [56]
D0933
 
Linezolid
 
C16H20FN3O4
 
441401 
Moderate    Inter Info   
[54], [55], [56]
D1051
 
Metronidazole
 
C6H9N3O3
 
4173 
Moderate    Inter Info   
[54], [55], [56]
D1118
 
Nelarabine
 
C11H15N5O5
 
3011155 
Moderate    Inter Info   
[54], [55], [56]
D1193
 
Oxaliplatin
 
C8H14N2O4Pt
 
9887053 
Moderate    Inter Info   
[54], [55], [56]
D1212
 
Paclitaxel
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[54], [55], [56]
D1213
 
Paclitaxel (protein-bound)
 
C47H51NO14
 
36314 
Moderate    Inter Info   
[54], [55], [56]
D1237
 
Peginterferon alfa-2a
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D1238
 
Peginterferon alfa-2b
 
NA
 
NA
Moderate    Inter Info   
[54], [55], [56]
D1504
 
Stavudine
 
C10H12N2O4
 
18283 
Moderate    Inter Info   
[54], [55], [56]
D1543
 
Telbivudine
 
C10H14N2O5
 
159269 
Moderate    Inter Info   
[54], [55], [56]
D1551
 
Teniposide
 
C32H32O13S
 
452548 
Moderate    Inter Info   
[54], [55], [56]
D1569
 
Thalidomide
 
C13H10N2O4
 
5426 
Moderate    Inter Info   
[57], [21], [22], [106]
D1587
 
Tinidazole
 
C8H13N3O4S
 
5479 
Moderate    Inter Info   
[54], [55], [56]
D1697
 
Vinblastine
 
C46H58N4O9
 
13342 
Moderate    Inter Info   
[54], [55], [56]
D1698
 
Vincristine
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[54], [55], [56]
D1699
 
Vincristine (liposome)
 
C46H56N4O10
 
5978 
Moderate    Inter Info   
[54], [55], [56]
D1700
 
Vinorelbine
 
C45H54N4O8
 
5311497 
Moderate    Inter Info   
[54], [55], [56]
D1714
 
Zafirlukast
 
C31H33N3O6S
 
5717 
Moderate    Inter Info   
[54], [55], [56]
D1715
 
Zalcitabine
 
C9H13N3O3
 
24066 
Moderate    Inter Info   
[57], [107]
   Potentiated the pharmacological effects (Unspecific) Drug Num:  3
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0074
 
Amphetamine
 
C9H13N
 
3007 
Minor    Inter Info   
[4], [108], [61]
D1276
 
Phenylephrine
 
C9H13NO2
 
6041 
Minor    Inter Info   
[4], [108], [61]
D1281
 
Phenylpropanolamine
 
C9H13NO
 
26934 
Minor    Inter Info   
[4], [108], [61]
   Increased risk of other adverse reactions (Unspecific) Drug Num:  8
Drug ID
 
Drug Name
 Formula Pubchem ID Severity Level Interaction Detail REF
D0120
 
Atorvastatin
 
C33H35FN2O5
 
60823 
Major    Inter Info   
[8], [20], [28]
D0303
 
Cerivastatin
 
C26H34FNO5
 
446156 
Major    Inter Info   
[8], [20], [28]
D1301
 
Pitavastatin
 
C25H24FNO4
 
5282452 
Major    Inter Info   
[8], [20], [28]
D0686
 
Fluvastatin
 
C24H26FNO4
 
446155 
Major    Inter Info   
[8], [20], [28]
D0956
 
Lovastatin
 
C24H36O5
 
53232 
Major    Inter Info   
[8], [20], [28]
D1329
 
Pravastatin
 
C23H36O7
 
54687 
Major    Inter Info   
[8], [20], [28]
D1430
 
Rosuvastatin
 
C22H28FN3O6S
 
446157 
Major    Inter Info   
[8], [20], [28]
D1473
 
Simvastatin
 
C25H38O5
 
54454 
Major    Inter Info   
[8], [20], [28]
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77 Product Information. Balversa (erdafitinib). Janssen Products, LP, Horsham, PA.
78 Product Information. Intelence (etravirine). Ortho Biotech Inc, Bridgewater, NJ.
79 Product Information. Tavalisse (fostamatinib). Rigel Pharmaceuticals, South San Francisco, CA.
80 Product Information. Imbruvica (ibrutinib). Pharmacyclics Inc, Sunnyvale, CA.
81 Product Information. Tibsovo (ivosidenib). Agios Pharmaceuticals, Cambridge, MA.
82 Product Information. Vitrakvi (larotrectinib). Bayer Pharmaceutical Inc, West Haven, CT.
83 Product Information. Xenleta (lefamulin). Nabriva Therapeutics US, Inc., King of Prussia, PA.
84 Product Information. Lorbrena (lorlatinib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
85 Product Information. Synribo (omacetaxine). Teva Pharmaceuticals USA, North Wales, PA.
86 Product Information. Tagrisso (osimertinib). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
87 Product Information. Ibrance (palbociclib). Pfizer U.S. Pharmaceuticals Group, New York, NY.
88 Product Information. Xofigo (radium Ra 223 dichloride). Bayer Pharmaceutical Inc, West Haven, CT.
89 Product Information. Retevmo (selpercatinib). Lilly, Eli and Company, Indianapolis, IN.
90 Product Information. Zorbtive (somatropin). Serono Laboratories Inc, Rockland, MA.
91 Product Information. Humatrope (somatropin). Lilly, Eli and Company, Indianapolis, IN.
92 Multum Information Services, Inc. Expert Review Panel.
93 Product Information. Prograf (tacrolimus). Fujisawa, Deerfield, IL.
94 Product Information. Rapamune (sirolimus) Wyeth-Ayerst Laboratories, Philadelphia, PA.
95 Product Information. Brilinta (ticagrelor). Astra-Zeneca Pharmaceuticals, Wilmington, DE.
96 Product Information. Jynarque (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
97 Product Information. Samsca (tolvaptan). Otsuka American Pharmaceuticals Inc, Rockville, MD.
98 Product Information. Stelara (ustekinumab). Centocor Inc, Malvern, PA.
99 Product Information. Cytovene (ganciclovir). Genentech, South San Francisco, CA.
100 Product Information. Valcyte (valganciclovir) Roche Laboratories, Nutley, NJ.
101 Product Information. Sprycel (dasatinib). Bristol-Myers Squibb, Princeton, NJ.
102 Product Information. Sustiva (efavirenz). DuPont Pharmaceuticals, Wilmington, DE.
103 Product Information. ORAVIG (miconazole). Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ.
104 Product Information. Priftin (rifapentine). Hoechst Marion-Roussel Inc, Kansas City, MO.
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106 Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.
107 Product Information. Hivid (zalcitabine). Roche Laboratories, Nutley, NJ.
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110 Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
111 Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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