Drug General Information (ID: DDI58T6JYX)
Drug Name			Amphetamine		Drug Info		Colchicine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cns Stimulants				Antigout Agents
Structure

Mechanism of Amphetamine-Colchicine Interaction (Severity Level: Minor)
Potentiated the pharmacological effects (Unspecific) Click to Show/Hide Mechanism Graph
Drug Name		Amphetamine				Colchicine
Mechanism		Sympathomimetic amine				Potentiate the pharmacologic effects of sympathomimetic amine
Key Mechanism Factor 1
		Factor Name		Pharmacodynamics
		Factor Description		Enhanced pharmacological effects leading to increased adverse reactions.
Mechanism Description		Potentiate the pharmacologic effects by the combination of Amphetamine and Colchicine

References
1	Akdag I, Ersoy A, Kahvecioglu S, Gullulu M, Dilek K "Acute colchicine intoxication during clarithromycin administration in patients with chronic renal failure." J Nephrol 19 (2006): 515-7. [PMID: 17048210]
2	Goldbart A, Press J, Sofer S, Kapelushnik J "Near fatal acute colchicine intoxication in a child. A case report." Eur J Pediatr 159 (2000): 895-7. [PMID: 11131346]
3	Product Information. Colchicine (colchicine). Lilly, Eli and Company, Indianapolis, IN.