Drug General Information (ID: DDISCF1MOA)
Drug Name			Phenylpropanolamine		Drug Info		Digitoxin		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Appetite Depressants				Antiarrhythmic Agents
Structure

Mechanism of Phenylpropanolamine-Digitoxin Interaction (Severity Level: Moderate)
Increased risk of ventricular arrhythmias Click to Show/Hide Mechanism Graph
Drug Name		Phenylpropanolamine				Digitoxin
Mechanism		Cardiac arrhythmias				Cardiac arrhythmias
Key Mechanism Factor 1
		Factor Name		Ventricular arrhythmias
		Factor Description		Ventricular arrhythmias are abnormal heart rhythms that cause your heart's lower chambers to pump blood instead of pumping it. This can limit or stop your heart from supplying blood to your body. While some of these arrhythmias are harmless and do not cause symptoms, others can have serious, even fatal, effects on your body.
Mechanism Description		Increased risk of ventricular arrhythmias by the combination of Phenylpropanolamine and Digitoxin

Recommended Action
Management		Caution should be exercised if these two drugs are coadministered. Electrocardiogram monitoring (ECG) is recommended. The use of epinephrine (adrenaline) with high doses of digitalis glycosides is not recommended.

References
1	Product Information. Lanoxin (digoxin). Glaxo Wellcome, Research Triangle Park, NC.
2	Product Information. Claritin-D (loratadine-pseudoephedrine). Schering-Plough, Liberty Corner, NJ.
3	Product Information. Epinephrine Hydrochloride Injection (epinephrine). Abbott Pharmaceutical, Abbott Park, IL.