Drug General Information (ID: DDIDSWNGT1)
Drug Name			Thiethylperazine		Drug Info		Phenylpropanolamine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiemetics				Appetite Depressants
Structure

Mechanism of Thiethylperazine-Phenylpropanolamine Interaction (Severity Level: Moderate)
Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph
Drug Name		Thiethylperazine				Phenylpropanolamine
Mechanism		Antidopaminergic effects Dopamine receptor  Antagonist				Dopaminergic effects Dopamine receptor  Agonist
Key Mechanism Factor 1
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Phenylpropanolamine when combined with Thiethylperazine

Recommended Action
Management		Amphetamine, amphetamine derivatives, and other CNS stimulants should generally not be used, particularly for weight reduction, in patients treated with phenothiazines.

References
1	Lake CR "Manic psychosis after coffee and phenylpropanolamine." Biol Psychiatry 30 (1991): 401-4. [PMID: 1912131]
2	Markowitz JS, Patrick KS "Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder." Clin Pharmacokinet 40 (2001): 753-72. [PMID: 11707061]
3	Reid AA "Pharmacological antagonism between chlorpromazine and phenmetrazine in mental hospital patients." Med J Aust 1 (1964): 187-8. [PMID: 14126355]