Details of Drug

Drug General Information (ID: D1572)
Drug Name	Thiethylperazine
Drug Type	Small molecule
Drug Synonymous	ETHYLTHIOPERAZINE; Theithylperazine; Thiethylperazinum; Thiethylpipezazine; Thioethylperazine; Tietilperazina; Torecan; Tietilperazina [DCIT]; Thiethylperazinum [INN-Latin]; Torecan (TN); Thiethylperazine (USAN/INN); Thiethylperazine [USAN:INN:BAN]; Norzine (Dimaleate); GS-95 (Dimaleate) Click to Show/Hide
Disease Class	MD90: Nausea/vomiting
Therapeutic Class	Antiemetics
Structure
Structure	3D Structure		2D Structure
Formula	C22H29N3S2
InChI	1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
InChIKey	XCTYLCDETUVOIP-UHFFFAOYSA-N
Canonical SMILES	CCSC1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN4CCN(CC4)C
External Link
	Pubchem ID	5440
	CAS Number	1420-55-9
	CHEBI ID	9544
	TTD ID	D0Y0ER

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM003 Affected organization distribution AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects AM007 Pharmacodynamic antagonistic effects BM004 Adsorption BM014 Interference of cell/tissue uptake BM017 CYP450 enzyme inhibition BM024 Competitive inhibition of metabolic enzyme BM033 Additive anticholinergic effects BM034 Additive antidopaminergic effects BM035 Additive antimotility effects BM038 Additive CNS depression effects BM042 Additive hypotensive effects BM054 Increased risk of GI mucosal injury/bleeding risk BM060 Increased risk of hyperprolactinemia BM061 Increased risk of hyperpyrexia BM069 Increased risk of lowers seizure threshold BM075 Increased risk of photosensitivity reactions BM076 Increased risk of prolong QT interval BM086 Antagonize the effect of antidiabetic agents BM089 Antagonize the effect of antihypertensive agents BM091 Antagonize the effect of cholinergic agents BM093 Antagonize the effect of dopaminergic agents BM107 Attenuated pharmacological effects (Unspecific) BM109 Increased risk of other adverse reactions (Unspecific)
Relation Graph

Full list of drugs interacting with Thiethylperazine
Affected gastrointestinal absorption
	Adsorption					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0021		Activated charcoal	C	5462310	Moderate		Inter Info	[174], [175], [176], [177], [178], [179], [180], [181], [182], [183], [184], [185], [186], [187], [188], [189], [190], [191], [192], [193], [194], [195], [196], [197], [198]
D1511		Sucralfate	C12H54Al9O55S8	121494085	Minor		Inter Info	[302], [303], [304], [305], [306]
D0968		Magnesium carbonate	CMgO3	11029	Minor		Inter Info	[302], [303], [306]
D0973		Magnesium hydroxide	H2MgO2	14791	Minor		Inter Info	[302], [303], [304], [305], [306]
D0974		Magnesium oxide	MgO	14792	Minor		Inter Info	[302], [303], [304], [305], [306]
Affected organization distribution
	Interference of cell/tissue uptake					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1821		Iobenguane (I-123)	C8H10IN3	60860	Moderate		Inter Info	[247], [248], [249]
D1825		Ioflupane I-123	C18H23FINO2	3086674	Moderate		Inter Info	[247], [248], [250]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 11
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0220		Bupropion	C13H18ClNO	444	Major		Inter Info	[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19]
D0007		Abiraterone	C24H31NO	132971	Moderate		Inter Info	[171]
D0298		Celecoxib	C17H14F3N3O2S	2662	Moderate		Inter Info	[206]
D0424		Darifenacin	C28H30N2O2	444031	Moderate		Inter Info	[207]
D0539		Duloxetine	C18H19NOS	60835	Moderate		Inter Info	[215], [216]
D0676		Fluoxetine	C17H18F3NO	3386	Moderate		Inter Info	[222], [223], [224], [225], [226], [227], [228], [229], [230], [231], [232], [233], [234]
D0793		Imatinib	C29H31N7O	5291	Moderate		Inter Info	[246]
D0952		Lorcaserin	C11H14ClN	11658860	Moderate		Inter Info	[247], [274], [248]
D1229		Paroxetine	C19H20FNO3	43815	Moderate		Inter Info	[286], [287], [288]
D1415		Ritonavir	C37H48N6O5S2	392622	Moderate		Inter Info	[293]
D1553		Terbinafine	C21H25N	1549008	Moderate		Inter Info	[294], [295], [296], [297]
	Competitive inhibition of metabolic enzyme					Drug Num: 10
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0068		Amitriptyline	C20H23N	2160	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
D1361		Protriptyline	C19H21N	4976	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
D0072		Amoxapine	C17H16ClN3O	2170	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
D0361		Clomipramine	C19H23ClN2	2801	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
D0446		Desipramine	C18H22N2	2995	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
D0525		Doxepin	C19H21NO	667477	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
D0526		Doxepin (topical)	C19H21NO	667477	Moderate		Inter Info	[84], [88], [90]
D0795		Imipramine	C19H24N2	3696	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
D1158		Nortriptyline	C19H21N	4543	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
D1647		Trimipramine	C20H26N2	5584	Moderate		Inter Info	[80], [67], [68], [81], [82], [83], [84], [69], [85], [86], [87], [88], [89], [90], [91], [92]
Pharmacodynamic additive effects
	Additive anticholinergic effects					Drug Num: 71
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0160		Benzatropine	C21H25NO	1201549	Moderate		Inter Info	[141], [85], [91]
D0196		Botulinum toxin type A	NA	NA	Moderate		Inter Info	[142], [143], [144]
D0197		Botulinum Toxin Type B	NA	NA	Moderate		Inter Info	[142], [143], [144]
D0351		Clemastine	C21H26ClNO	26987	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0370		Clozapine	C18H19ClN4	135398737	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0508		Disopyramide	C21H29N3O	3114	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0532		Doxylamine	C17H22N2O	3162	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0842		Ipratropium	C20H30NO3+	657309	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D1166		Olanzapine	C17H20N4S	135398745	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0019		Aclidinium	C26H30NO4S2+	11434515	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D0020		Acrivastine	C22H24N2O2	5284514	Moderate		Inter Info	[141], [85], [91]
D0105		Aripiprazole	C23H27Cl2N3O2	60795	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0112		Asenapine	C17H16ClNO	3036780	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0123		Atropine	C17H23NO3	174174	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0154		Belladonna	C34H42N2O4	265028	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0183		Biperiden	C21H29NO	2381	Moderate		Inter Info	[141], [85], [91]
D0202		Brexpiprazole	C25H27N3O2S	11978813	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0214		Brompheniramine	C16H19BrN2	6834	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0259		Carbinoxamine	C16H19ClN2O	2564	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0262		Cariprazine	C21H32Cl2N4O	11154555	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0323		Chlorpheniramine	C16H19ClN2	2725	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0324		Chlorpromazine	C17H19ClN2S	2726	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0353		Clidinium	C22H26NO3+	2784	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0398		Cyclobenzaprine	C20H21N	2895	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0403		Cyproheptadine	C21H21N	2913	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0456		Dexbrompheniramine	C16H19BrN2	16960	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0482		Dicyclomine	C19H35NO2	3042	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0498		Dimenhydrinate	C24H28ClN5O3	10660	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0502		Diphenhydramine	C17H21NO	3100	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0655		Fesoterodine	C26H37NO3	6918558	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0662		Flavoxate	C24H25NO4	3354	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0678		Fluphenazine	C22H26F3N3OS	3372	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0733		Glycopyrronium	C19H28NO3+	3494	Moderate		Inter Info	[141], [85], [91]
D0734		Glycopyrronium (topical)	C19H28NO3+	3494	Moderate		Inter Info	[164], [166], [167]
D0750		Haloperidol	C21H23ClFNO2	3559	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0759		Homatropine	C16H21NO3	5282593	Moderate		Inter Info	[141], [85], [91]
D0781		Hydroxyzine	C21H27ClN2O2	3658	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0782		Hyoscyamine	C17H23NO3	154417	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0791		Iloperidone	C24H27FN2O4	71360	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0957		Loxapine	C18H18ClN3O	3964	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0959		Lumateperone	C24H28FN3O	21302490	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0979		Maprotiline	C20H23N	4011	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0987		Meclizine	C25H27ClN2	4034	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0998		Memantine	C12H21N	4054	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1000		Mepenzolate	C21H26NO3+	4057	Moderate		Inter Info	[141], [85], [91]
D1006		Mepyramine	C17H23N3O	4992	Moderate		Inter Info	[141], [85], [91]
D1010		Mesoridazine	C21H26N2OS2	4078	Moderate		Inter Info	[141], [85], [91]
D1031		Methscopolamine	C18H24NO4+	71183	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1084		Molindone	C16H24N2O2	23897	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1188		Orphenadrine	C18H23NO	4601	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1202		Oxybutynin	C22H31NO3	4634	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1257		Perphenazine	C21H26ClN3OS	4748	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1282		Phenyltoloxamine	C17H21NO	7077	Moderate		Inter Info	[141], [85], [91]
D1292		Pimozide	C28H29F2N3O	16362	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1347		Procyclidine	C19H29NO	4919	Moderate		Inter Info	[141], [85], [91]
D1352		Promethazine	C17H20N2S	4927	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1368		Quetiapine	C21H25N3O2S	5002	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1396		Revefenacin	C35H43N5O4	11753673	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D1413		Risperidone	C23H27FN4O2	5073	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1450		Scopolamine	C17H21NO4	3000322	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1491		Solifenacin	C23H26N2O2	154059	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1576		Thiothixene	C23H29N3O2S2	941651	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1590		Tiotropium	C19H22NO4S2+	5487427	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D1607		Tolterodine	C22H31NO	443879	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1637		Trifluoperazine	C21H24F3N3S	5566	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1641		Trihexyphenidyl	C20H31NO	5572	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1650		Triprolidine	C19H22N2	5282443	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1665		Umeclidinium	C29H34NO2+	11519070	Moderate		Inter Info	[163], [164], [165], [166], [167], [168], [169], [170]
D1656		Trospium	C25H30NO3+	5284632	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D1726		Ziprasidone	C21H21ClN4OS	60854	Moderate		Inter Info	[157], [158], [159], [82], [83], [141], [84], [85], [87], [160], [161], [162], [89], [91], [92]
D0843		Ipratropium (nasal)	C20H30NO3+	657309	Minor		Inter Info	[247], [301], [248]
	Additive antidopaminergic effects					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0452		Deutetrabenazine	C19H27NO3	73437646	Major		Inter Info	[20]
D1046		Metoclopramide	C14H22ClN3O2	4168	Major		Inter Info	[29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], [40], [41], [42], [43]
D1560		Tetrabenazine	C19H27NO3	6018	Major		Inter Info	[58], [59], [60], [61], [62], [63], [64], [65], [66]
	Additive antimotility effects					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0947		Loperamide	C29H33ClN2O2	3955	Moderate		Inter Info	[273]
	Additive CNS depression effects					Drug Num: 105
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0467		Dextropropoxyphene	C22H29NO2	10100	Major		Inter Info	[21], [22], [23]
D1485		Sodium oxybate	C4H7NaO3	23663870	Major		Inter Info	[56], [57]
D1730		Zonisamide	C8H8N2O3S	5734	Major		Inter Info	[70]
D1609		Topiramate	C12H21NO8S	5284627	Major		Inter Info	[71]
D0030		Aldesleukin	NA	NA	Moderate		Inter Info	[77], [78], [79]
D0143		Baclofen	C10H12ClNO2	2284	Moderate		Inter Info	[138], [139], [140]
D0305		Cetirizine	C21H25ClN2O3	2678	Moderate		Inter Info	[155], [156]
D0345		Citalopram	C20H21FN2O	2771	Moderate		Inter Info	[138], [139], [140]
D0356		Clobazam	C16H13ClN2O2	2789	Moderate		Inter Info	[138], [139], [140]
D0776		Hydromorphone	C17H19NO3	5284570	Moderate		Inter Info	[138], [139], [140]
D0951		Lorazepam	C15H10Cl2N2O2	3958	Moderate		Inter Info	[138], [139], [140]
D1005		Meprobamate	C9H18N2O4	4064	Moderate		Inter Info	[138], [139], [140]
D1017		Methadone	C21H27NO	4095	Moderate		Inter Info	[138], [139], [140]
D1089		Morphine	C17H19NO3	5288826	Moderate		Inter Info	[138], [139], [140]
D1335		Pregabalin	C8H17NO2	5486971	Moderate		Inter Info	[138], [139], [140]
D1547		Temazepam	C16H13ClN2O2	5391	Moderate		Inter Info	[138], [139], [140]
D0035		Alfentanil	C21H32N6O3	51263	Moderate		Inter Info	[138], [139], [140]
D0045		Alprazolam	C17H13ClN4	2118	Moderate		Inter Info	[138], [139], [140]
D0098		Apraclonidine	C9H10Cl2N4	2216	Moderate		Inter Info	[203], [79], [204]
D0161		Benzhydrocodone	C25H25NO4	49836084	Moderate		Inter Info	[138], [139], [140]
D0201		Brexanolone	C21H34O2	92786	Moderate		Inter Info	[205]
D0205		Brimonidine (ophthalmic)	C11H10BrN5	2435	Moderate		Inter Info	[203], [79], [204]
D0206		Brimonidine (topical)	C11H10BrN5	2435	Moderate		Inter Info	[203], [79], [204]
D0208		Brivaracetam	C11H20N2O2	9837243	Moderate		Inter Info	[138], [139], [140]
D0212		Bromocriptine	C32H40BrN5O5	31101	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
D0219		Buprenorphine	C29H41NO4	644073	Moderate		Inter Info	[138], [139], [140]
D0222		Buspirone	C21H31N5O2	2477	Moderate		Inter Info	[138], [139], [140]
D0226		Butorphanol	C21H29NO2	5361092	Moderate		Inter Info	[138], [139], [140]
D0248		Cannabidiol	C21H30O2	644019	Moderate		Inter Info	[138], [139], [140]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[138], [139], [140]
D0263		Carisoprodol	C12H24N2O4	2576	Moderate		Inter Info	[138], [139], [140]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[138], [139], [140]
D0317		Chlordiazepoxide	C16H14ClN3O	2712	Moderate		Inter Info	[138], [139], [140]
D0362		Clonazepam	C15H10ClN3O3	2802	Moderate		Inter Info	[138], [139], [140]
D0365		Clorazepic acid	C16H11ClN2O3	2809	Moderate		Inter Info	[138], [139], [140]
D0451		Desvenlafaxine	C16H25NO2	125017	Moderate		Inter Info	[138], [139], [140]
D0466		Dextromethorphan	C18H25NO	5360696	Moderate		Inter Info	[138], [139], [140]
D0473		Diazepam	C16H13ClN2O	3016	Moderate		Inter Info	[138], [139], [140]
D0493		Dihydrocodeine	C18H23NO3	5284543	Moderate		Inter Info	[138], [139], [140]
D0533		Dronabinol	C21H30O2	16078	Moderate		Inter Info	[138], [139], [140]
D0535		Droperidol	C22H22FN3O2	3168	Moderate		Inter Info	[138], [139], [140]
D0575		Entacapone	C14H15N3O5	5281081	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
D0599		Escitalopram	C20H21FN2O	146570	Moderate		Inter Info	[138], [139], [140]
D0600		Esketamine	C13H16ClNO	182137	Moderate		Inter Info	[30], [218]
D0601		Eslicarbazepine	C15H14N2O2	9881504	Moderate		Inter Info	[138], [139], [140]
D0612		Eszopiclone	C17H17ClN6O3	969472	Moderate		Inter Info	[138], [139], [140]
D0617		Ethanol	C2H6O	702	Moderate		Inter Info	[219], [220]
D0620		Ethosuximide	C7H11NO2	3291	Moderate		Inter Info	[138], [139], [140]
D0646		Fentanyl	C22H28N2O	3345	Moderate		Inter Info	[138], [139], [140]
D0665		Flibanserin	C20H21F3N4O	6918248	Moderate		Inter Info	[221]
D0679		Flurazepam	C21H23ClFN3O	3393	Moderate		Inter Info	[138], [139], [140]
D0772		Hydrocodone	C18H21NO3	5284569	Moderate		Inter Info	[138], [139], [140]
D0790		Ifosfamide	C7H15Cl2N2O2P	3690	Moderate		Inter Info	[243], [244], [245]
D0853		Isocarboxazid	C12H13N3O2	3759	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D0878		Kava	C14H16O3	5281052	Moderate		Inter Info	[138], [139], [140]
D0879		Ketamine	C13H16ClNO	3821	Moderate		Inter Info	[138], [139], [140]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[266]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[138], [139], [140]
D0917		Levocetirizine	C21H25ClN2O3	1549000	Moderate		Inter Info	[155], [156]
D0918		Levodopa	C9H11NO4	6047	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
D0923		Levorphanol	C17H23NO	5359272	Moderate		Inter Info	[138], [139], [140]
D0933		Linezolid	C16H20FN3O4	441401	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D0940		Lithium carbonate	CLi2O3	11125	Moderate		Inter Info	[270], [271], [272]
D1001		Meperidine	C15H21NO2	4058	Moderate		Inter Info	[276], [277], [278], [279], [280]
D1032		Methsuximide	C12H13NO2	6476	Moderate		Inter Info	[138], [139], [140]
D1060		Midazolam	C18H13ClFN3	4192	Moderate		Inter Info	[138], [139], [140]
D1096		Nabilone	C24H36O3	5284592	Moderate		Inter Info	[138], [139], [140]
D1100		Nalbuphine	C21H27NO4	5311304	Moderate		Inter Info	[138], [139], [140]
D1169		Oliceridine	C22H30N2O2S	66553195	Moderate		Inter Info	[138], [139], [140]
D1172		Olopatadine (nasal)	C21H23NO3	5281071	Moderate		Inter Info	[244], [285], [248]
D1182		Opicapone	C15H10Cl2N4O6	135565903	Moderate		Inter Info	[148], [151], [153]
D1183		Opium	NA	NA	Moderate		Inter Info	[138], [139], [140]
D1197		Oxazepam	C15H11ClN2O2	4616	Moderate		Inter Info	[138], [139], [140]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[138], [139], [140]
D1203		Oxycodone	C18H21NO4	5284603	Moderate		Inter Info	[138], [139], [140]
D1208		Oxymorphone	C17H19NO4	5284604	Moderate		Inter Info	[138], [139], [140]
D1211		Ozanimod	C23H24N4O3	52938427	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D1247		Pentazocine	C19H27NO	441278	Moderate		Inter Info	[138], [139], [140]
D1252		Pentoxyverine	C20H31NO3	2562	Moderate		Inter Info	[138], [139], [140]
D1253		Perampanel	C23H15N3O	9924495	Moderate		Inter Info	[138], [139], [140]
D1255		Pergolide	C19H26N2S	47811	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
D1263		Phenelzine	C8H12N2	3675	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D1325		Pramipexole	C10H17N3S	119570	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
D1345		Procarbazine	C12H19N3O	4915	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D1378		Ramelteon	C16H21NO2	208902	Moderate		Inter Info	[138], [139], [140]
D1385		Rasagiline	C12H13N	3052776	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D1390		Remifentanil	C20H28N2O5	60815	Moderate		Inter Info	[138], [139], [140]
D1391		Remimazolam	C21H19BrN4O2	9867812	Moderate		Inter Info	[138], [139], [140]
D1431		Rotigotine	C19H25NOS	59227	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[138], [139], [140]
D1437		Safinamide	C17H19FN2O2	131682	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D1455		Selegiline	C13H17N	26757	Moderate		Inter Info	[251], [252], [253], [254], [255], [256], [257], [258], [259], [260], [261], [262], [263], [264], [265]
D1505		Stiripentol	C14H18O3	5311454	Moderate		Inter Info	[138], [139], [140]
D1512		Sufentanil	C22H30N2O2S	41693	Moderate		Inter Info	[138], [139], [140]
D1524		Suvorexant	C23H23ClN6O2	24965990	Moderate		Inter Info	[138], [139], [140]
D1535		Tapentadol	C14H23NO	9838022	Moderate		Inter Info	[138], [139], [140]
D1536		Tasimelteon	C15H19NO2	10220503	Moderate		Inter Info	[138], [139], [140]
D1569		Thalidomide	C13H10N2O4	5426	Moderate		Inter Info	[244], [298], [248]
D1596		Tizanidine	C9H8ClN5S	5487	Moderate		Inter Info	[299]
D1620		Tranylcypromine	C9H11N	19493	Moderate		Inter Info	[254], [258], [265]
D1632		Triazolam	C17H12Cl2N4	5556	Moderate		Inter Info	[138], [139], [140]
D1675		Valerian	NA	NA	Moderate		Inter Info	[138], [139], [140]
D1694		Vigabatrin	C6H11NO2	5665	Moderate		Inter Info	[138], [139], [140]
D1719		Ziconotide	C102H172N36O32S7	16135415	Moderate		Inter Info	[138], [139], [140]
D1677		Valproic acid	C8H16O2	3121	Moderate		Inter Info	[138], [139], [140]
	Additive hypotensive effects					Drug Num: 79
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1147		Nitroprusside	C5FeN6O	11953891	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0083		Amyl Nitrite	C5H11NO2	10026	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0267		Carvedilol	C24H26N2O4	2585	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0524		Doxazosin	C23H25N5O5	3157	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0587		Eprosartan	C23H24N2O4S	5281037	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[131], [133], [135]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[131], [133], [135]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0860		Isosorbide	C6H10O4	12597	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D0980		Maraviroc	C29H41F2N5O	3002977	Moderate		Inter Info	[275]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1146		Nitroglycerin	C3H5N3O9	4510	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1256		Perindopril	C19H32N2O5	107807	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[131], [133], [135]
D1331		Prazosin	C19H21N5O4	4893	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[131], [133], [135]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[127], [128], [129], [130], [131], [132], [133], [134], [135], [136], [137]
	Increased risk of GI mucosal injury/bleeding risk					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1318		Potassium chloride	ClK	4873	Major		Inter Info	[44], [45], [46]
D1319		Potassium citrate	C6H5K3O7	13344	Major		Inter Info	[44], [47], [45], [48], [49], [46], [50], [51], [52], [53], [54], [55]
	Increased risk of lowers seizure threshold					Drug Num: 9
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0833		Iohexol	C19H26I3N3O9	3730	Major		Inter Info	[24], [25], [26], [27], [28]
D0834		Iopamidol	C17H22I3N3O8	65492	Major		Inter Info	[24], [25], [26], [27], [28]
D1616		Tramadol	C16H25NO2	33741	Major		Inter Info	[72], [9], [15], [73]
D0054		Amifampridine	C5H7N3	5918	Moderate		Inter Info	[199], [200]
D0722		Ginkgo biloba	NA	NA	Moderate		Inter Info	[235], [236], [237], [238], [239], [240], [241], [242]
D0932		Lindane	C6H6Cl6	727	Moderate		Inter Info	[267], [268], [269]
D1287		Picosulfuric acid	C18H15NO8S2	5243	Moderate		Inter Info	[289], [290], [79]
D1308		Polyethylene glycol (3350 with electrolytes)	C2H6O2	174	Moderate		Inter Info	[289], [290], [79]
D1488		Sodium sulfate	Na2O4S	24436	Moderate		Inter Info	[289], [79], [290]
	Increased risk of photosensitivity reactions					Drug Num: 5
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0063		Aminolevulinic acid (topical)	C5H9NO3	137	Moderate		Inter Info	[30], [79], [201]
D1028		Methoxsalen	C12H8O4	4114	Moderate		Inter Info	[30], [172], [281], [282], [283]
D1033		Methyl aminolevulinate (topical)	C6H11NO3	157922	Moderate		Inter Info	[30], [79], [201]
D1314		Porfimer sodium	C68H74N8O11	135577896	Moderate		Inter Info	[291], [79], [292]
D1691		Verteporfin	C82H84N8O16	11980904	Moderate		Inter Info	[79], [172], [281], [300]
	Increased risk of prolong QT interval					Drug Num: 1
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1574		Thioridazine	C21H26N2S2	5452	Major		Inter Info	[67], [68], [69]
	Increased risk of other adverse reactions (Unspecific)					Drug Num: 2
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0562		Eluxadoline	C32H35N5O5	11250029	Moderate		Inter Info	[79], [217]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[248], [244], [284]
Pharmacodynamic antagonistic effects
	Antagonize the effect of antidiabetic agents					Drug Num: 33
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0009		Acarbose	C25H43NO18	41774	Moderate		Inter Info	[74], [75], [76]
D0727		Glimepiride	C24H34N4O5S	3476	Moderate		Inter Info	[74], [75], [76]
D0811		Insulin glargine	C267H404N72O78S6	118984454	Moderate		Inter Info	[74], [75], [76]
D0814		Insulin human (inhalation, rapid acting)	C257H383N65O77S6	118984375	Moderate		Inter Info	[74], [75], [76]
D0815		Insulin human (isophane)	C257H383N65O77S6	118984375	Moderate		Inter Info	[74], [75], [76]
D0816		Insulin human (regular)	C257H383N65O77S6	118984375	Moderate		Inter Info	[74], [75], [76]
D0817		Insulin human (zinc extended)	C257H383N65O77S6	118984375	Moderate		Inter Info	[74], [75], [76]
D0819		Insulin lispro	C257H389N65O77S6	16132438	Moderate		Inter Info	[74], [75], [76]
D1015		Metformin	C4H11N5	4091	Moderate		Inter Info	[74], [75], [76]
D0029		Albiglutide	C148H224N40O45	145994868	Moderate		Inter Info	[74], [75], [76]
D0042		Alogliptin	C18H21N5O2	11450633	Moderate		Inter Info	[74], [75], [76]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[74], [75], [76]
D0325		Chlorpropamide	C10H13ClN2O3S	2727	Moderate		Inter Info	[74], [75], [76]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[74], [75], [76]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[74], [75], [76]
D0728		Glipizide	C21H27N5O4S	3478	Moderate		Inter Info	[74], [75], [76]
D0730		Glyburide	C23H28ClN3O5S	3488	Moderate		Inter Info	[74], [75], [76]
D0808		Insulin aspart (aspart)	C256H381N65O79S6	118984445	Moderate		Inter Info	[74], [75], [76]
D0809		Insulin degludec	C274H411N65O81S6	118984462	Moderate		Inter Info	[74], [75], [76]
D0810		Insulin detemir	C267H402N64O76S6	16137271	Moderate		Inter Info	[74], [75], [76]
D0812		Insulin glulisine	C258H384N64O78S6	16136701	Moderate		Inter Info	[74], [75], [76]
D0930		Linagliptin	C25H28N8O2	10096344	Moderate		Inter Info	[74], [75], [76]
D0936		Liraglutide	C172H265N43O51	16134956	Moderate		Inter Info	[74], [75], [76]
D0941		Lixisenatide	C215H347N61O65S	90472060	Moderate		Inter Info	[74], [75], [76]
D1064		Miglitol	C8H17NO5	441314	Moderate		Inter Info	[74], [75], [76]
D1112		Nateglinide	C19H27NO3	5311309	Moderate		Inter Info	[74], [75], [76]
D1294		Pioglitazone	C19H20N2O3S	4829	Moderate		Inter Info	[74], [75], [76]
D1326		Pramlintide	C171H267N51O53S2	70691388	Moderate		Inter Info	[74], [75], [76]
D1392		Repaglinide	C27H36N2O4	65981	Moderate		Inter Info	[74], [75], [76]
D1449		Saxagliptin	C18H25N3O2	11243969	Moderate		Inter Info	[74], [75], [76]
D1477		Sitagliptin	C16H15F6N5O	4369359	Moderate		Inter Info	[74], [75], [76]
D1601		Tolazamide	C14H21N3O3S	5503	Moderate		Inter Info	[74], [75], [76]
D1603		Tolbutamide	C12H18N2O3S	5505	Moderate		Inter Info	[74], [75], [76]
	Antagonize the effect of antihypertensive agents					Drug Num: 4
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D1779		Dulaglutide	NA	NA	Moderate		Inter Info	[74], [75], [76]
D1782		Ertugliflozin	C22H25ClO7	44814423	Moderate		Inter Info	[74], [75], [76]
D1784		Exenatide	C184H282N50O60S	45588096	Moderate		Inter Info	[74], [75], [76]
D1887		Semaglutide	C187H291N45O59	56843331	Moderate		Inter Info	[74], [75], [76]
	Antagonize the effect of cholinergic agents					Drug Num: 8
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0015		Acetylcholine	C7H16NO2+	187	Moderate		Inter Info	[172], [173]
D0256		Carbamoylcholine (ophthalmic)	C6H15N2O2+	2551	Moderate		Inter Info	[172], [173]
D0516		Donepezil	C24H29NO3	3152	Moderate		Inter Info	[208], [209], [210], [211], [212], [213]
D0546		Echothiophate (ophthalmic)	C9H23NO3PS+	10548	Moderate		Inter Info	[172], [173]
D0707		Galantamine	C17H21NO3	9651	Moderate		Inter Info	[208], [209], [210], [211], [212], [213]
D1285		Physostigmine	C15H21N3O2	5983	Moderate		Inter Info	[208], [209], [210], [211], [212], [213]
D1289		Pilocarpine (ophthalmic)	C11H16N2O2	5910	Moderate		Inter Info	[172], [173]
D1418		Rivastigmine	C14H22N2O2	77991	Moderate		Inter Info	[208], [209], [210], [211], [212], [213]
	Antagonize the effect of dopaminergic agents					Drug Num: 16
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0074		Amphetamine	C9H13N	3007	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D0228		Cabergoline	C26H37N5O2	54746	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
D1270		Phentermine	C10H15N	4771	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D1427		Ropinirole	C16H24N2O	5095	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
D0097		Apomorphine	C17H17NO2	6005	Moderate		Inter Info	[202]
D0165		Benzphetamine	C17H21N	5311017	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D0460		Dexmethylphenidate	C14H19NO2	154101	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D0465		Dextroamphetamine	C9H13N	5826	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D0486		Diethylpropion	C13H19NO	7029	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D0579		Ephedrine	C10H15NO	9294	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D0937		Lisdexamfetamine	C15H25N3O	11597698	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D1012		Metamfetamine	C10H15N	10836	Moderate		Inter Info	[102], [105], [122]
D1039		Methylphenidate	C14H19NO2	4158	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D1262		Phendimetrazine	C12H17NO	30487	Moderate		Inter Info	[93], [94], [95], [96], [97], [98], [99], [100], [101], [102], [103], [104], [105], [106], [107], [108], [109], [110], [111], [112], [113], [114], [115], [116], [117], [118], [119], [120], [121], [122], [123], [124], [125], [126]
D1281		Phenylpropanolamine	C9H13NO	26934	Moderate		Inter Info	[102], [105], [122]
D1604		Tolcapone	C14H11NO5	4659569	Moderate		Inter Info	[145], [146], [132], [147], [148], [149], [150], [38], [151], [133], [134], [135], [136], [152], [153], [154]
	Attenuated pharmacological effects (Unspecific)					Drug Num: 3
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0517		Dopamine	C8H11NO2	681	Moderate		Inter Info	[131], [135], [214]
D0581		Epinephrine	C9H13NO3	5816	Moderate		Inter Info	[131], [135], [214]
D0921		Levonordefrin	C9H13NO3	164739	Moderate		Inter Info	[131], [135], [214]

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52	Product Information. K-Dur (potassium chloride). Schering Laboratories, Kenilworth, NJ.
53	Product Information. Urocit (potassium citrate). Mission Pharmacal Company, San Antonio, TX.
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111	Product Information. Cylert (pemoline). Abbott Pharmaceutical, Abbott Park, IL.
112	Product Information. Desoxyn (methamphetamine) Abbott Pharmaceutical, Abbott Park, IL.
113	Product Information. Dexedrine (dextroamphetamine) SmithKline Beecham, Philadelphia, PA.
114	Product Information. Didrex (benzphetamine) Pharmacia and Upjohn, Kalamazoo, MI.
115	Product Information. Fastin (phentermine). SmithKline Beecham, Philadelphia, PA.
116	Product Information. Focalin (dexmethylphenidate). Mikart Inc, Atlanta, GA.
117	Product Information. Prelu-2 (phendimetrazine) Boehringer-Ingelheim, Ridgefield, CT.
118	Product Information. Ritalin (methylphenidate). Novartis Pharmaceuticals, East Hanover, NJ.
119	Product Information. Sanorex (mazindol) Novartis Pharmaceuticals, East Hanover, NJ.
120	Product Information. Tenuate (diethylpropion) Aventis Pharmaceuticals, Swiftwater, PA.
121	Product Information. Vyvanse (lisdexamfetamine). Shire US Inc, Florence, KY.
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131	Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
132	Product Information. Geodon (ziprasidone). Pfizer US Pharmaceuticals, New York, NY.
133	Product Information. Rexulti (brexpiprazole). Otsuka American Pharmaceuticals Inc, Rockville, MD.
134	Product Information. Risperdal (risperidone). Janssen Pharmaceutica, Titusville, NJ.
135	Product Information. Seroquel (quetiapine). Zeneca Pharmaceuticals, Wilmington, DE.
136	Product Information. Zyprexa (olanzapine). Lilly, Eli and Company, Indianapolis, IN.
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142	Product Information. Botox (onabotulinumtoxin A). Allergan Inc, Irvine, CA.
143	Product Information. Myobloc (botulinum toxin type B) Elan Pharmaceuticals, S. San Francisco, CA.
144	Product Information. Xeomin (botulinum toxin type A (obsolete) (botulinum toxin type A)). Merz Pharmaceuticals, Greensboro, NC.
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146	Product Information. Dostinex (cabergoline). Pharmacia and Upjohn, Kalamazoo, MI.
147	Product Information. Mirapex (pramipexole). Boehringer Ingelheim, Ridgefield, CT.
148	Product Information. Norprolac (quinagolide). Ferring Inc, North York, IA.
149	Product Information. Parlodel (bromocriptine). Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
150	Product Information. Permax (pergolide). Athena Neurosciences Inc, South San Francisco, CA.
151	Product Information. Requip (ropinirole). SmithKline Beecham, Philadelphia, PA.
152	Robbins RJ, Kern PA, Thompson TL "Interactions between thioridazine and bromocriptine in a patient with a prolactin-secreting pituitary adenoma." Am J Med 76 (1984): 921-3. [PMID: 6720732]
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155	Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
156	Product Information. Xyzal (levocetirizine). UCB Pharma Inc, Smyrna, GA.
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160	Product Information. Artane (trihexyphenidyl). Lederle Laboratories, Wayne, NJ.
161	Product Information. Cogentin (benztropine). Merck & Co, Inc, West Point, PA.
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166	Product Information. Combivent (albuterol-ipratropium). Boehringer-Ingelheim, Ridgefield, CT.
167	Product Information. Qbrexza (glycopyrrolate topical). Dermira, Inc., Menlo Park, CA.
168	Product Information. Spiriva (tiotropium). Boehringer Ingelheim, Ridgefield, CT.
169	Product Information. Tudorza Pressair (aclidinium). Forest Pharmaceuticals, St. Louis, MO.
170	Product Information. Yupelri (revefenacin). Mylan Specialty, Morgantown, WV.
171	Product Information. Zytiga (abiraterone). Centocor Inc, Malvern, PA.
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173	Product Information. Pilopine HS (pilocarpine ophthalmic). Alcon Laboratories Inc, Fort Worth, TX.
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200	Product Information. Firdapse (amifampridine). Catalyst Pharmaceuticals, Inc., Coral Gables, FL.
201	Product Information. Metvixia (methyl aminolevulinate topical). Galderma Laboratories Inc, Cranbury, NJ.
202	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.
203	Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
204	Product Information. Mirvaso (brimonidine topical). Galderma Laboratories Inc, Cranbury, NJ.
205	Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
206	Product Information. Celebrex (celecoxib). Searle, Chicago, IL.
207	Product Information. Enablex (darifenacin). Novartis Pharmaceuticals, East Hanover, NJ.
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214	Product Information. Loxitane C Oral Concentrate (loxapine) Watson Laboratories Inc, Corona, CA.
215	Product Information. Cymbalta (duloxetine). Lilly, Eli and Company, Indianapolis, IN.
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218	Product Information. Spravato (esketamine). Janssen Pharmaceuticals, Titusville, NJ.
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221	Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
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