Drug General Information (ID: DDISY59QJL)
Drug Name			Thiethylperazine		Drug Info		Apomorphine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Antiemetics				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Thiethylperazine-Apomorphine Interaction (Severity Level: Moderate)
Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph
Drug Name		Thiethylperazine				Apomorphine
Mechanism		Antidopaminergic effects Dopamine receptor  Antagonist				Dopaminergic effects Dopamine receptor  Agonist
Key Mechanism Factor 1
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Apomorphine when combined with Thiethylperazine

Recommended Action
Management		The use of apomorphine in combination with dopamine antagonists should generally be avoided unless the potential benefits outweigh the risks. Monitoring for altered efficacy of apomorphine and increased side effects such as sedation or hypotension is recommended if concomitant use is required. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. Also, they should avoid activities requiring mental alertness until they know how these agents affect them. Patients who experience increased episodes of falling asleep during normal daily activities should avoid driving and other potentially hazardous activities until they have been evaluated by their physician.

References
1	Product Information. Apokyn (apomorphine). Mylan Pharmaceuticals Inc, Morgantown, WV.