Drug General Information (ID: DDIRUNHBIY)
  Drug Name Thiethylperazine Drug Info Lithium carbonate Drug Info
  Drug Type Small molecule Small molecule
  Therapeutic Class Antiemetics Antimanic Agents
  Structure

 Mechanism of Thiethylperazine-Lithium carbonate Interaction (Severity Level: Moderate)
     Additive CNS depression effects Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Thiethylperazine Lithium carbonate
      Mechanism 1 CNS depression effects CNS depression effects
      Key Mechanism Factor 1
Factor Name CNS depression effects
Factor Description CNS depressants are drugs that inhibit or suppress brain activity and can reduce mental and physical processes. Excessive CNS depression can lead to decreased heart rate, slow breathing (less than 10 breaths per minute), extreme confusion or loss of memory, nausea and vomiting, poor judgment, blue lips or fingertips, irritability and aggression, and clammy or cold skin.
      Mechanism Description
  • Additive CNS depression effects by the combination of Thiethylperazine and Lithium carbonate 
     Increased risk of lowers seizure threshold Click to Show/Hide Mechanism Graph
Could Not Find 2D Structure
      Drug Name Thiethylperazine Lithium carbonate
      Mechanism 2 Lower seizure threshold Lower seizure threshold
      Key Mechanism Factor 2
Factor Name Lowers seizure threshold
Factor Description The combination of medications that lower the seizure threshold is a factor that makes people with epilepsy more likely to have seizures. A seizure is a sudden, uncontrolled electrical disturbance in the brain that can cause changes in your behavior, movements or sensations, and level of consciousness.
      Mechanism Description
  • Increased risk of lowers seizure threshold by the combination of Thiethylperazine and Lithium carbonate 

Recommended Action
      Management Patients receiving lithium and a phenothiazine should be closely monitored for altered efficacy and safety. In some circumstances, discontinuation of one or both agents may be necessary.

References
1 Product Information. Eskalith (lithium). SmithKline Beecham, Philadelphia, PA.
2 Rivera-Calimlim L, Kerzner B, Karch FE "Effect of lithium on plasma chlorpromazine levels." Clin Pharmacol Ther 23 (1978): 451-5. [PMID: 630793]
3 Sachdev PS "Lithium potentiation of neuroleptic-related extrapyramidal side effects." Am J Psychiatry 143 (1986): 942. [PMID: 3087223]