Drug General Information (ID: DDIUXT2D0H)
Drug Name			Phenylpropanolamine		Drug Info		Haloperidol		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Appetite Depressants				Antipsychotic Agents
Structure

Mechanism of Phenylpropanolamine-Haloperidol Interaction (Severity Level: Moderate)
Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph
Drug Name		Phenylpropanolamine				Haloperidol
Mechanism		Dopaminergic effects Dopamine receptor  Agonist				Antidopaminergic effects Dopamine receptor  Antagonist
Key Mechanism Factor 1
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Phenylpropanolamine when combined with Haloperidol

Recommended Action
Management		Amphetamine, amphetamine derivatives, and other CNS stimulants should generally not be used, particularly for weight reduction, in patients treated with a butyrophenone neuroleptic agent.

References
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