Drug General Information (ID: DDII7SELBN)
Drug Name			Phenylpropanolamine		Drug Info		Alimemazine		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Appetite Depressants				Antihistamines
Structure

Mechanism of Phenylpropanolamine-Alimemazine Interaction (Severity Level: Moderate)
Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph
Drug Name		Phenylpropanolamine				Alimemazine
Mechanism		Dopaminergic effects Dopamine receptor  Agonist				Antidopaminergic effects Dopamine receptor  Antagonist
Key Mechanism Factor 1
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Phenylpropanolamine when combined with Alimemazine

Recommended Action
Management		Amphetamine, amphetamine derivatives, and other CNS stimulants should generally not be used, particularly for weight reduction, in patients treated with phenothiazines.

References
1	Lake CR "Manic psychosis after coffee and phenylpropanolamine." Biol Psychiatry 30 (1991): 401-4. [PMID: 1912131]
2	Markowitz JS, Patrick KS "Pharmacokinetic and pharmacodynamic drug interactions in the treatment of attention-deficit hyperactivity disorder." Clin Pharmacokinet 40 (2001): 753-72. [PMID: 11707061]
3	Reid AA "Pharmacological antagonism between chlorpromazine and phenmetrazine in mental hospital patients." Med J Aust 1 (1964): 187-8. [PMID: 14126355]