Drug General Information (ID: DDIT3V8Z2O)
Drug Name			Levodopa		Drug Info		Magnesium hydroxide		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Dopaminergic Antiparkinsonism Agents				Antacids/Laxatives
Structure

Mechanism of Levodopa-Magnesium hydroxide Interaction (Severity Level: Minor)
Altered gastric pH Click to Show/Hide Mechanism Graph
Drug Name		Levodopa				Magnesium hydroxide
Mechanism		Gastric pH sensitive				Gastric alkalinizer
Key Mechanism Factor 1
		Factor Name		Gastric pH
		Factor Description		The normal pH range of gastric acid is between 1.5 and 3.5 and is highly acidic, consisting mainly of hydrochloric acid. Changes in the pH of the stomach can alter the absorption of drugs.
Mechanism Description		Decreased absorption of Levodopa due to altered gastric pH caused by Magnesium hydroxide

References
1	Fermaglich J, O'Dougherty DS "Effect of gastric motility on levodopa." Dis Nerv Syst 33 (1972): 624-5. [PMID: 4649158]
2	Product Information. Sinemet (carbidopa-levodopa). DuPont Pharmaceuticals, Wilmington, DE.
3	Rivera-Calimlim L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "Absorption and metabolism of L-dopa by the human stomach." Eur J Clin Invest 1 (1971): 313-20. [PMID: 5558777]
4	Rivera-Calimlin L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "L-dopa treatment failure: explanation and correction." Br Med J 4 (1970): 93-4. [PMID: 5482325]