Drug General Information (ID: DDIPMWO74V)
Drug Name			Memantine		Drug Info		Levodopa		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Cholinesterase Inhibitors				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Memantine-Levodopa Interaction (Severity Level: Minor)
Additive dopaminergic effects Click to Show/Hide Mechanism Graph
Drug Name		Memantine				Levodopa
Mechanism		Dopaminergic effects Dopamine receptor  Agonist				Dopaminergic effects Dopamine receptor  Agonist
Key Mechanism Factor 1
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Additive dopaminergic effects by the combination of Memantine and Levodopa

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Multum Information Services, Inc. Expert Review Panel.