Drug General Information (ID: DDIP3Q9K7F)
Drug Name			Pyridoxine		Drug Info		Levodopa		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vitamins				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Pyridoxine-Levodopa Interaction (Severity Level: Moderate)
Antagonize the effect of dopaminergic agents Click to Show/Hide Mechanism Graph
Drug Name		Pyridoxine				Levodopa
Mechanism		Antidopaminergic effects Increase peripheral metabolism of levodopa				Dopaminergic agent Dopamine receptor  Agonist
Key Mechanism Factor 1
		Factor Name		Dopamine receptor				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.     Click to Show/Hide
Mechanism Description		Antagonize the effect of Levodopa when combined with Pyridoxine

Recommended Action
Management		The concomitant use of pyridoxine and levodopa without dopa-decarboxylase inhibitors should be avoided. Patients should be advised against taking pyridoxine-containing vitamin supplements.

References
1	Cerner Multum, Inc. "UK Summary of Product Characteristics.".
2	Product Information. Diclectin (doxylamine-pyridoxine). Duchesnay Inc, Laval, IN.