Drug General Information (ID: DDI5YHUZBE)
Drug Name			Amitriptyline		Drug Info		Levodopa		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Analgesics				Dopaminergic Antiparkinsonism Agents
Structure

Mechanism of Amitriptyline-Levodopa Interaction (Severity Level: Minor)
Altered gastrointestinal dynamics Click to Show/Hide Mechanism Graph
Drug Name		Amitriptyline				Levodopa
Mechanism		Delayed gastric emptying				Absorption affected by delayed gastric emptying
Key Mechanism Factor 1
		Factor Name		Gastrointestinal Motility
		Factor Description		Gastrointestinal motility is an important factor in determining the absorption of orally administered drugs, and it controls the residence time of the drug in the digestive tract.
Mechanism Description		Altered absorption of Levodopa due to GI dynamics variation caused by Amitriptyline

References
1	Morgan JP, Rivera-Calimlim L, Messiha F, Sundaresan PR, Trabert N "Imipramine-mediated interference with levodopa absorption from the gastrointestinal tract in man." Neurology 25 (1975): 1029-34. [PMID: 1237820]
2	Rampton DS "Hypertensive crisis in a patient given Sinemet, metoclopramide, and amitriptyline." Br Med J 2 (1977): 607-8. [PMID: 901999]