Drug General Information (ID: DDISJVQ086)
Drug Name			Rocuronium		Drug Info		Trimethaphan		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Neuromuscular Blocking Agents				Antihypertensive Agents
Structure

Mechanism of Rocuronium-Trimethaphan Interaction (Severity Level: Moderate)
Additive neuromuscular blocking effects Click to Show/Hide Mechanism Graph
Drug Name		Rocuronium				Trimethaphan
Mechanism		Neuromuscular blocking agent Neuronal acetylcholine receptor  Antagonist				Neuromuscular blocking effects
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive neuromuscular blocking effects by the combination of Rocuronium and Trimethaphan

Recommended Action
Management		Observation for profound and prolonged respiratory depression and muscle weakness is recommended if these drugs must be used together.

References
1	Multum Information Services, Inc. Expert Review Panel.
2	Product Information. Anectine (succinylcholine). Glaxo Wellcome, Research Triangle Park, NC.