Drug General Information (ID: DDIS4EH2LO)
Drug Name			Pentoxifylline		Drug Info		Trimethaphan		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Vasodilator Agents				Antihypertensive Agents
Structure

Mechanism of Pentoxifylline-Trimethaphan Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Pentoxifylline				Trimethaphan
Mechanism 1		Antihypertensive agent				Antihypertensive agent Neuronal acetylcholine receptor  Antagonist
Key Mechanism Factor 1
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Pentoxifylline and Trimethaphan
Mechanism 2		Hypotensive effects				Antihypertensive agent Neuronal acetylcholine receptor  Antagonist
Key Mechanism Factor 2
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Pentoxifylline and Trimethaphan

Recommended Action
Management		Caution is advised if pentoxifylline is used in combination with hypotensive agents. Periodic systemic blood pressure monitoring is recommended.

References
1	Product Information. Trental (pentoxifylline). Hoechst Marion-Roussel Inc, Kansas City, MO.