Details of Drug Interaction | MecDDI

Drug General Information (ID: DDIE457J8Y)
Drug Name			Dexmedetomidine		Drug Info		Trimethaphan		Drug Info
Drug Type		Small molecule				Small molecule
Therapeutic Class		Anxiolytics/Sedatives/Hypnotics				Antihypertensive Agents
Structure

Mechanism of Dexmedetomidine-Trimethaphan Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph

Drug Name		Dexmedetomidine				Trimethaphan
Mechanism		Hypotensive effects Alpha-2 adrenergic receptor Agonist				Antihypertensive agent Neuronal acetylcholine receptor Antagonist
Key Mechanism Factor 1
		Factor Name		Adrenergic receptor alpha-2				Structure Sequence
		Protein Family		G-protein coupled receptor 1 family
		Protein Function		Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Click to Show/Hide
Key Mechanism Factor 2
		Factor Name		Neuronal acetylcholine receptor				Structure Sequence
		Protein Family		Ligand-gated ion channel (TC 1.A.9) family
		Protein Function		After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Dexmedetomidine and Trimethaphan

Recommended Action
Management		Caution and monitoring of the patient's hemodynamic status are recommended during coadministration.

References
1	Cerner Multum, Inc. "Australian Product Information.".
2	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
3	Product Information. Precedex (dexmedetomidine) Abbott Pharmaceutical, Abbott Park, IL.