Drug General Information (ID: DDI1FPHWRZ)
Drug Name			Aldesleukin		Drug Info		Nitroglycerin		Drug Info
Drug Type		Interferons				Small molecule
Therapeutic Class		Antineoplastics				Vasodilator Agents

Mechanism of Aldesleukin-Nitroglycerin Interaction (Severity Level: Moderate)
Additive hypotensive effects Click to Show/Hide Mechanism Graph
Drug Name		Aldesleukin				Nitroglycerin
Mechanism 1		Antihypertensive agent				Antihypertensive agent Guanylate cyclase  Agonist
Key Mechanism Factor 1
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Aldesleukin and Nitroglycerin
Mechanism 2		Hypotensive effects				Antihypertensive agent Guanylate cyclase  Agonist
Key Mechanism Factor 2
		Factor Name		Guanylate cyclase soluble				Structure Sequence
		Protein Family		Adenylyl cyclase class-4/guanylyl cyclase family
		Protein Function		There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms. Activated by nitric oxide in the presence of magnesium or manganese ions.     Click to Show/Hide
Mechanism Description		Additive hypotensive effects by the combination of Aldesleukin and Nitroglycerin

Recommended Action
Management		Blood pressure should be monitored during concomitant administration. Aldesleukin doses should be held if systolic blood pressure falls to less than 90 mmHg.

References
1	Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA.