Details of Drug-Drug Interaction
| Drug General Information (ID: DDIVD9BA2C) | |||||||||
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| Drug Name | Aldesleukin | Drug Info | Eprosartan | Drug Info | |||||
| Drug Type | Interferons | Small molecule | |||||||
| Therapeutic Class | Antineoplastics | Antihypertensive Agents | |||||||
| Mechanism of Aldesleukin-Eprosartan Interaction (Severity Level: Moderate) | |||||||||
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| Additive hypotensive effects Click to Show/Hide Mechanism Graph | |||||||||
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| Drug Name | Aldesleukin | Eprosartan | |||||||
| Mechanism 1 | Antihypertensive agent |
Antihypertensive agent Angiotensin II receptor Antagonist |
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| Key Mechanism Factor 1 | |||||||||
| Factor Name | Angiotensin II receptor | Structure Sequence | |||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
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| Mechanism Description |
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| Mechanism 2 | Hypotensive effects |
Antihypertensive agent Angiotensin II receptor Antagonist |
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| Key Mechanism Factor 2 | |||||||||
| Factor Name | Angiotensin II receptor | Structure Sequence | |||||||
| Protein Family | G-protein coupled receptor 1 family | ||||||||
| Protein Function |
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.; (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.
Click to Show/Hide
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| Mechanism Description |
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| Recommended Action | |||||||||
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| Management | Blood pressure should be monitored during concomitant administration. Aldesleukin doses should be held if systolic blood pressure falls to less than 90 mmHg. | ||||||||
| References | |||||||||||||||||||
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| 1 | Product Information. Proleukin (aldesleukin). Chiron Therapeutics, Emeryville, CA. | ||||||||||||||||||