Details of Drug

Drug General Information (ID: D1408)
Drug Name	Riociguat
Drug Type	Small molecule
Drug Synonymous	Riociguat; 625115-55-1; Adempas; Riociguat (BAY 63-2521); BAY 63-2521; riociguatum; UNII-RU3FE2Y4XI; RU3FE2Y4XI; CHEBI:76018; Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate; Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate; N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester Click to Show/Hide
Disease Class	BB01: Pulmonary hypertension
Therapeutic Class	Vasodilator Agents
Structure
Structure	3D Structure		2D Structure
Formula	C20H19FN8O2
InChI	1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
InChIKey	WXXSNCNJFUAIDG-UHFFFAOYSA-N
Canonical SMILES	CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC
External Link
	Pubchem ID	11304743
	CAS Number	625115-55-1
	CHEBI ID	76018
	TTD ID	D04UKC
	INTEDE ID	DR1427
	VARIDT ID	DR00080

Drug-Drug Interaction Network
Sunburst Graph		Legend Information AM001 Affected gastrointestinal absorption AM002 Affected cellular transport AM004 Affected intra/extra-hepatic metabolism AM006 Pharmacodynamic additive effects BM005 Altered gastric pH BM010 Transporter inhibition BM017 CYP450 enzyme inhibition BM022 CYP450 enzyme induction BM042 Additive hypotensive effects
Relation Graph

Full list of drugs interacting with Riociguat
Affected gastrointestinal absorption
	Altered gastric pH					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0049		Aluminum hydroxide	AlH3O3	10176082	Moderate		Inter Info	[3]
D0236		Calcium carbonate	CCaO3	10112	Moderate		Inter Info	[3]
D0458		Dexlansoprazole	C16H14F3N3O2S	9578005	Moderate		Inter Info	[3]
D0603		Esomeprazole	C17H19N3O3S	9568614	Moderate		Inter Info	[3]
D0892		Lansoprazole	C16H14F3N3O2S	3883	Moderate		Inter Info	[3]
D0974		Magnesium oxide	MgO	14792	Moderate		Inter Info	[3]
D1179		Omeprazole	C17H19N3O3S	4594	Moderate		Inter Info	[3]
D1222		Pantoprazole	C16H15F2N3O4S	4679	Moderate		Inter Info	[3]
D1373		Rabeprazole	C18H21N3O3S	5029	Moderate		Inter Info	[3]
D0967		Magaldrate	AlHMgO5S+2	3086011	Moderate		Inter Info	[3]
D0968		Magnesium carbonate	CMgO3	11029	Moderate		Inter Info	[3]
D0973		Magnesium hydroxide	H2MgO2	14791	Moderate		Inter Info	[3]
D1483		Sodium citrate	C6H5Na3O7	6224	Moderate		Inter Info	[3]
D1480		Sodium bicarbonate	CHNaO3	516892	Moderate		Inter Info	[3]
Affected cellular transport
	Transporter inhibition					Drug Num: 14
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0867		Itraconazole	C35H38Cl2N8O4	55283	Major		Inter Info	[1], [2], [3], [4]
D0375		Cobicistat	C40H53N7O5S2	25151504	Major		Inter Info	[1], [2], [3], [4]
D1415		Ritonavir	C37H48N6O5S2	392622	Major		Inter Info	[1], [2], [3], [4]
D0139		Azithromycin	C38H72N2O12	447043	Moderate		Inter Info	[1], [2], [3]
D0170		Bepridil	C24H34N2O	2351	Moderate		Inter Info	[1], [2], [3]
D0402		Cyclosporine	C62H111N11O12	5284373	Moderate		Inter Info	[1], [2], [3]
D1348		Progesterone	C21H30O2	5994	Moderate		Inter Info	[1], [2], [3]
D0044		Alpelisib	C19H22F3N5O2S	56649450	Moderate		Inter Info	[2], [12], [13]
D0568		Enasidenib	C19H17F6N7O	89683805	Moderate		Inter Info	[1], [14]
D0720		Gilteritinib	C29H44N8O3	49803313	Moderate		Inter Info	[1], [2], [15]
D0897		Lasmiditan	C19H18F3N3O2	11610526	Moderate		Inter Info	[16]
D1539		Tedizolid	C17H15FN6O3	11234049	Moderate		Inter Info	[2], [20]
D1526		Tacrolimus	C44H69NO12	445643	Moderate		Inter Info	[1], [2], [3]
D1664		Ulipristal	C28H35NO3	13559281	Moderate		Inter Info	[1], [2], [3]
Affected intra/extra-hepatic metabolism
	CYP450 enzyme inhibition					Drug Num: 39
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0880		Ketoconazole	C26H28Cl2N4O4	456201	Major		Inter Info	[1], [2], [3], [4]
D1119		Nelfinavir	C32H45N3O4S	64143	Major		Inter Info	[1], [2], [3], [4]
D1444		Saquinavir	C38H50N6O5	441243	Major		Inter Info	[1], [2], [3], [4]
D0001		Abacavir	C14H18N6O	441300	Moderate		Inter Info	[5], [1], [2], [6]
D0066		Amiodarone	C25H29I2NO3	2157	Moderate		Inter Info	[1], [2], [3]
D0080		Amprenavir	C25H35N3O6S	65016	Moderate		Inter Info	[1], [2], [3]
D0116		Atazanavir	C38H52N6O7	148192	Moderate		Inter Info	[1], [2], [3]
D0192		Boceprevir	C27H45N5O5	10324367	Moderate		Inter Info	[1], [2], [3]
D0349		Clarithromycin	C38H69NO13	84029	Moderate		Inter Info	[1], [2], [3]
D0386		Conivaptan	C32H26N4O2	151171	Moderate		Inter Info	[1], [2], [3]
D0393		Crizotinib	C21H22Cl2FN5O	11626560	Moderate		Inter Info	[1], [2], [3]
D0439		Delavirdine	C22H28N6O3S	5625	Moderate		Inter Info	[1], [2], [3]
D0497		Diltiazem	C22H26N2O4S	39186	Moderate		Inter Info	[1], [2], [3]
D0595		Erlotinib	C22H23N3O4	176870	Moderate		Inter Info	[5], [1], [2], [6]
D0597		Erythromycin	C37H67NO13	12560	Moderate		Inter Info	[1], [2], [3]
D0692		Fosamprenavir	C25H36N3O9PS	131536	Moderate		Inter Info	[1], [2], [3]
D0713		Gefitinib	C22H24ClFN4O3	123631	Moderate		Inter Info	[5], [1], [2], [6]
D0799		Indinavir	C36H47N5O4	5362440	Moderate		Inter Info	[1], [2], [3]
D0869		Ivacaftor	C24H28N2O3	16220172	Moderate		Inter Info	[1], [2], [3]
D0894		Lapatinib	C29H26ClFN4O4S	208908	Moderate		Inter Info	[1], [2], [3]
D0944		Lomitapide	C39H37F6N3O2	9853053	Moderate		Inter Info	[1], [2], [3]
D0946		Lonafarnib	C27H31Br2ClN4O2	148195	Moderate		Inter Info	[1], [2], [3]
D1117		Nefazodone	C25H32ClN5O2	4449	Moderate		Inter Info	[1], [2], [3]
D1136		Nilotinib	C28H22F3N7O	644241	Moderate		Inter Info	[1], [2], [3]
D1315		Posaconazole	C37H42F2N8O4	468595	Moderate		Inter Info	[1], [2], [3]
D1371		Quinidine	C20H24N2O2	441074	Moderate		Inter Info	[1], [2], [3]
D1372		Quinine	C20H24N2O2	3034034	Moderate		Inter Info	[1], [2], [3]
D1383		Ranolazine	C24H33N3O4	56959	Moderate		Inter Info	[1], [2], [3]
D0251		Capmatinib	C23H17FN6O	25145656	Moderate		Inter Info	[1], [2], [3]
D0302		Ceritinib	C28H36ClN5O3S	57379345	Moderate		Inter Info	[1], [2], [3]
D0789		Idelalisib	C22H18FN7O	11625818	Moderate		Inter Info	[1], [2], [3]
D1660		Tucatinib	C26H24N8O2	51039094	Moderate		Inter Info	[1], [2], [3]
D1501		Spironolactone	C24H32O4S	5833	Moderate		Inter Info	[1], [2], [3]
D1533		Tamoxifen	C26H29NO	2733526	Moderate		Inter Info	[1], [2], [3]
D1541		Telaprevir	C36H53N7O6	3010818	Moderate		Inter Info	[1], [2], [3]
D1544		Telithromycin	C43H65N5O10	3002190	Moderate		Inter Info	[1], [2], [3]
D1608		Tolvaptan	C26H25ClN2O3	216237	Moderate		Inter Info	[1], [2], [3]
D1690		Verapamil	C27H38N2O4	2520	Moderate		Inter Info	[1], [2], [3]
D1706		Voriconazole	C16H14F3N5O	71616	Moderate		Inter Info	[1], [2], [3]
	CYP450 enzyme induction					Drug Num: 43
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0061		Aminoglutethimide	C13H16N2O2	2145	Moderate		Inter Info	[3]
D0071		Amobarbital	C11H18N2O3	2164	Moderate		Inter Info	[3]
D0178		Bexarotene	C24H28O2	82146	Moderate		Inter Info	[3]
D0194		Bosentan	C27H29N5O6S	104865	Moderate		Inter Info	[3]
D0224		Butabarbital	C10H16N2O3	2479	Moderate		Inter Info	[3]
D0225		Butalbital	C11H16N2O3	2481	Moderate		Inter Info	[3]
D0255		Carbamazepine	C15H12N2O	2554	Moderate		Inter Info	[3]
D0300		Cenobamate	C10H10ClN5O2	11962412	Moderate		Inter Info	[3]
D0432		Deferasirox	C21H15N3O4	214348	Moderate		Inter Info	[3]
D0453		Dexamethasone	C22H29FO5	5743	Moderate		Inter Info	[3]
D0554		Efavirenz	C14H9ClF3NO2	64139	Moderate		Inter Info	[3]
D0578		Enzalutamide	C21H16F4N4O2S	15951529	Moderate		Inter Info	[3]
D0628		Etravirine	C20H15BrN6O	193962	Moderate		Inter Info	[3]
D0697		Fosphenytoin	C16H15N2O6P	56339	Moderate		Inter Info	[3]
D1040		Methylphenobarbital	C13H14N2O3	8271	Moderate		Inter Info	[3], [10], [11]
D1078		Mitotane	C14H10Cl4	4211	Moderate		Inter Info	[3]
D1099		Nafcillin	C21H22N2O5S	8982	Moderate		Inter Info	[3]
D1128		Nevirapine	C15H14N4O	4463	Moderate		Inter Info	[3]
D1198		Oxcarbazepine	C15H12N2O2	34312	Moderate		Inter Info	[3]
D1248		Pentobarbital	C11H18N2O3	4737	Moderate		Inter Info	[3]
D1265		Phenobarbital	C12H12N2O3	4763	Moderate		Inter Info	[3]
D1274		Phenylbutazone	C19H20N2O2	4781	Moderate		Inter Info	[3]
D1283		Phenytoin	C15H12N2O2	1775	Moderate		Inter Info	[3]
D1340		Primidone	C12H14N2O2	4909	Moderate		Inter Info	[3]
D1399		Rifabutin	C46H62N4O11	135398743	Moderate		Inter Info	[3]
D1400		Rifampicin	C43H58N4O12	135398735	Moderate		Inter Info	[3], [10], [11]
D1401		Rifapentine	C47H64N4O12	135403821	Moderate		Inter Info	[3]
D0095		Apalutamide	C21H15F4N5O2S	24872560	Moderate		Inter Info	[3]
D0555		Elagolix	C32H30F5N3O5	11250647	Moderate		Inter Info	[3]
D0872		Ivosidenib	C28H22ClF3N6O3	71657455	Moderate		Inter Info	[3]
D0901		Lemborexant	C22H20F2N4O2	56944144	Moderate		Inter Info	[3], [10], [11]
D0953		Lorlatinib	C21H19FN6O2	71731823	Moderate		Inter Info	[3]
D1493		Somapacitan	C54H95N13O20S2	129894493	Moderate		Inter Info	[3], [10], [11]
D1495		Somatrem	C43H72N14O14	5487805	Moderate		Inter Info	[3]
D1433		Rufinamide	C10H8F2N4O	129228	Moderate		Inter Info	[3]
D1453		Secobarbital	C12H18N2O3	5193	Moderate		Inter Info	[3]
D1494		Somatotropin	NA	NA	Moderate		Inter Info	[3], [10], [11]
D1502		St. John's Wort	NA	NA	Moderate		Inter Info	[3]
D1518		Sulfinpyrazone	C23H20N2O3S	5342	Moderate		Inter Info	[3]
D1652		Troglitazone	C24H27NO5S	5591	Moderate		Inter Info	[3]
D1687		Vemurafenib	C23H18ClF2N3O3S	42611257	Moderate		Inter Info	[3]
D0106		Armodafinil	C15H15NO2S	9690109	Minor		Inter Info	[21], [22], [23], [24], [25]
D1081		Modafinil	C15H15NO2S	4236	Minor		Inter Info	[21], [22], [23], [24], [25]
Pharmacodynamic additive effects
	Additive hypotensive effects					Drug Num: 109
Drug ID		Drug Name	Formula	Pubchem ID	Severity Level		Interaction Detail	REF
D0064		Aminophylline	C16H24N10O4	9433	Major		Inter Info	[1], [2], [3]
D0083		Amyl Nitrite	C5H11NO2	10026	Major		Inter Info	[3]
D0128		Avanafil	C23H26ClN7O3	9869929	Major		Inter Info	[1], [2], [3]
D0506		Dipyridamole	C24H40N8O4	3108	Major		Inter Info	[1], [2], [3]
D0544		Dyphylline	C10H14N4O4	3182	Major		Inter Info	[1], [2], [3]
D0861		Isosorbide dinitrate	C6H8N2O8	6883	Major		Inter Info	[3]
D0862		Isosorbide mononitrate	C6H9NO6	27661	Major		Inter Info	[3]
D1146		Nitroglycerin	C3H5N3O9	4510	Major		Inter Info	[3]
D1147		Nitroprusside	C5FeN6O	11953891	Major		Inter Info	[3]
D1201		Oxtriphylline	C12H21N5O3	656652	Major		Inter Info	[1], [2], [3]
D0860		Isosorbide	C6H10O4	12597	Major		Inter Info	[3]
D1465		Sildenafil	C22H30N6O4S	135398744	Major		Inter Info	[1], [2], [3]
D1527		Tadalafil	C22H19N3O4	110635	Major		Inter Info	[1], [2], [3]
D1570		Theophylline	C7H8N4O2	2153	Major		Inter Info	[1], [2], [3]
D1682		Vardenafil	C23H32N6O4S	135400189	Major		Inter Info	[1], [2], [3]
D0010		Acebutolol	C18H28N2O4	1978	Moderate		Inter Info	[3]
D0036		Alfuzosin	C19H27N5O4	2092	Moderate		Inter Info	[3]
D0046		Alprostadil	C20H34O5	5280723	Moderate		Inter Info	[3]
D0053		Ambrisentan	C22H22N2O4	6918493	Moderate		Inter Info	[3]
D0058		Amiloride	C6H8ClN7O	16231	Moderate		Inter Info	[3]
D0069		Amlodipine	C20H25ClN2O5	2162	Moderate		Inter Info	[3]
D0117		Atenolol	C14H22N2O3	2249	Moderate		Inter Info	[3]
D0138		Azilsartan medoxomil	C30H24N4O8	135409642	Moderate		Inter Info	[3]
D0156		Benazepril	C24H28N2O5	5362124	Moderate		Inter Info	[3]
D0158		Bendroflumethiazide	C15H14F3N3O4S2	2315	Moderate		Inter Info	[3]
D0166		Benzthiazide	C15H14ClN3O4S3	2343	Moderate		Inter Info	[3]
D0173		Betaxolol	C18H29NO3	2369	Moderate		Inter Info	[3]
D0188		Bisoprolol	C18H31NO4	2405	Moderate		Inter Info	[3]
D0217		Bumetanide	C17H20N2O5S	2471	Moderate		Inter Info	[3]
D0245		Canagliflozin	C24H25FO5S	24812758	Moderate		Inter Info	[1], [2], [7]
D0254		Captopril	C9H15NO3S	44093	Moderate		Inter Info	[3]
D0321		Chlorothiazide	C7H6ClN3O4S2	2720	Moderate		Inter Info	[3]
D0326		Chlorthalidone	C14H11ClN2O4S	2732	Moderate		Inter Info	[3]
D0352		Clevidipine	C21H23Cl2NO6	153994	Moderate		Inter Info	[3]
D0363		Clonidine	C9H9Cl2N3	2803	Moderate		Inter Info	[3]
D0396		Cyclandelate	C17H24O3	2893	Moderate		Inter Info	[3]
D0418		Dapagliflozin	C21H25ClO6	9887712	Moderate		Inter Info	[1], [2], [7]
D0444		Deserpidine	C32H38N2O8	8550	Moderate		Inter Info	[3]
D0459		Dexmedetomidine	C13H16N2	5311068	Moderate		Inter Info	[1], [8], [9]
D0474		Diazoxide	C8H7ClN2O2S	3019	Moderate		Inter Info	[3]
D0567		Enalapril	C20H28N2O5	5388962	Moderate		Inter Info	[3]
D0585		Eplerenone	C24H30O6	443872	Moderate		Inter Info	[3]
D0586		Epoprostenol	C20H32O5	5282411	Moderate		Inter Info	[3]
D0602		Esmolol	C16H25NO4	59768	Moderate		Inter Info	[3]
D0613		Etacrynic acid	C13H12Cl2O4	3278	Moderate		Inter Info	[3]
D0644		Fenoldopam	C16H16ClNO3	3341	Moderate		Inter Info	[3]
D0695		Fosinopril	C30H46NO7P	55891	Moderate		Inter Info	[3]
D0704		Furosemide	C12H11ClN2O5S	3440	Moderate		Inter Info	[3]
D0742		Guanabenz	C8H8Cl2N4	5702063	Moderate		Inter Info	[3]
D0743		Guanadrel	C10H19N3O2	38521	Moderate		Inter Info	[3]
D0744		Guanethidine	C10H22N4	3518	Moderate		Inter Info	[3]
D0745		Guanfacine	C9H9Cl2N3O	3519	Moderate		Inter Info	[3]
D0770		Hydralazine	C8H8N4	3637	Moderate		Inter Info	[3]
D0771		Hydrochlorothiazide	C7H8ClN3O4S2	3639	Moderate		Inter Info	[3]
D0775		Hydroflumethiazide	C8H8F3N3O4S2	3647	Moderate		Inter Info	[3]
D0792		Iloprost	C22H32O4	5311181	Moderate		Inter Info	[3]
D0798		Indapamide	C16H16ClN3O3S	3702	Moderate		Inter Info	[3]
D0844		Irbesartan	C25H28N6O	3749	Moderate		Inter Info	[3]
D0865		Isradipine	C19H21N3O5	3784	Moderate		Inter Info	[3]
D0884		Labetalol	C19H24N2O3	3869	Moderate		Inter Info	[3]
D0938		Lisinopril	C21H31N3O5	5362119	Moderate		Inter Info	[3]
D0942		Lofexidine	C11H12Cl2N2O	30668	Moderate		Inter Info	[3]
D0954		Losartan	C22H23ClN6O	3961	Moderate		Inter Info	[3]
D0978		Mannitol	C6H14O6	6251	Moderate		Inter Info	[3]
D0983		Mecamylamine	C11H21N	4032	Moderate		Inter Info	[3]
D1035		Methyldopa	C10H13NO4	38853	Moderate		Inter Info	[3]
D1048		Metolazone	C16H16ClN3O3S	4170	Moderate		Inter Info	[3]
D1049		Metoprolol	C15H25NO3	4171	Moderate		Inter Info	[3]
D1053		Metyrosine	C10H13NO3	441350	Moderate		Inter Info	[3]
D1072		Minoxidil	C9H15N5O	4201	Moderate		Inter Info	[3]
D1082		Moexipril	C27H34N2O7	91270	Moderate		Inter Info	[3]
D1098		Nadolol	C17H27NO4	39147	Moderate		Inter Info	[3]
D1114		Nebivolol	C22H25F2NO4	71301	Moderate		Inter Info	[3]
D1125		Nesiritide	C143H244N50O42S4	53325981	Moderate		Inter Info	[3]
D1130		Nicardipine	C26H29N3O6	4474	Moderate		Inter Info	[3]
D1134		Nifedipine	C17H18N2O6	4485	Moderate		Inter Info	[3]
D1138		Nimodipine	C21H26N2O7	4497	Moderate		Inter Info	[3]
D1141		Nisoldipine	C20H24N2O6	4499	Moderate		Inter Info	[3]
D1170		Olmesartan	C24H26N6O3	158781	Moderate		Inter Info	[3]
D1223		Papaverine	C20H21NO4	4680	Moderate		Inter Info	[3]
D1244		Penbutolol	C18H29NO2	37464	Moderate		Inter Info	[3]
D1267		Phenoxybenzamine	C18H22ClNO	4768	Moderate		Inter Info	[3]
D1271		Phentolamine	C17H19N3O	5775	Moderate		Inter Info	[3]
D1293		Pindolol	C14H20N2O2	4828	Moderate		Inter Info	[3]
D1311		Polythiazide	C11H13ClF3N3O4S3	4870	Moderate		Inter Info	[3]
D1357		Propranolol	C16H21NO2	4946	Moderate		Inter Info	[3]
D1369		Quinapril	C25H30N2O5	54892	Moderate		Inter Info	[3]
D1379		Ramipril	C23H32N2O5	5362129	Moderate		Inter Info	[3]
D1393		Reserpine	C33H40N2O9	5770	Moderate		Inter Info	[3]
D0038		Aliskiren	C30H53N3O6	5493444	Moderate		Inter Info	[3]
D0565		Empagliflozin	C23H27ClO7	11949646	Moderate		Inter Info	[1], [2], [7]
D0864		Isoxsuprine	C18H23NO3	3783	Moderate		Inter Info	[3]
D0911		Levamlodipine	C20H25ClN2O5	9822750	Moderate		Inter Info	[3]
D1148		Nitrous acid	HNO2	24529	Moderate		Inter Info	[17], [18], [19]
D1457		Selexipag	C26H32N4O4S	9913767	Moderate		Inter Info	[3]
D1466		Silodosin	C25H32F3N3O4	5312125	Moderate		Inter Info	[3]
D1498		Sotalol	C12H20N2O3S	5253	Moderate		Inter Info	[3]
D1534		Tamsulosin	C20H28N2O5S	129211	Moderate		Inter Info	[3]
D1545		Telmisartan	C33H30N4O2	65999	Moderate		Inter Info	[3]
D1552		Terazosin	C19H25N5O4	5401	Moderate		Inter Info	[3]
D1585		Timolol	C13H24N4O3S	33624	Moderate		Inter Info	[3]
D1602		Tolazoline	C10H12N2	5504	Moderate		Inter Info	[3]
D1611		Torasemide	C16H20N4O3S	41781	Moderate		Inter Info	[3]
D1618		Trandolapril	C24H34N2O5	5484727	Moderate		Inter Info	[3]
D1625		Treprostinil	C23H34O5	6918140	Moderate		Inter Info	[3]
D1631		Triamterene	C12H11N7	5546	Moderate		Inter Info	[3]
D1643		Trimethaphan	C22H25N2OS+	23576	Moderate		Inter Info	[3]
D1668		Urea	CH4N2O	1176	Moderate		Inter Info	[3]
D1679		Valsartan	C24H29N5O3	60846	Moderate		Inter Info	[3]

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4	Product Information. Sporanox (itraconazole). Janssen Pharmaceutica, Titusville, NJ.
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6	Product Information. Ziagen (abacavir). Glaxo Wellcome, Research Triangle Pk, NC.
7	Product Information. Jardiance (empagliflozin). Boehringer Ingelheim, Ridgefield, CT.
8	EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports.".
9	Product Information. Precedex (dexmedetomidine) Abbott Pharmaceutical, Abbott Park, IL.
10	Product Information. Diabinese (chlorpropamide). Pfizer US Pharmaceuticals, New York, NY.
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12	Product Information. Diovan (valsartan). Novartis Pharmaceuticals, East Hanover, NJ.
13	Product Information. Piqray (alpelisib). Novartis Pharmaceuticals, East Hanover, NJ.
14	Product Information. Idhifa (enasidenib). Celgene Corporation, Summit, NJ.
15	Product Information. Xospata (gilteritinib). Astellas Pharma US, Inc, Deerfield, IL.
16	Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
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19	Product Information. Sodium Nitrite (sodium nitrite). Hope Pharmaceuticals, Scottsdale, AZ.
20	Product Information. Sivextro (tedizolid). Cubist Pharmaceuticals Inc, Lexington, MA.
21	Doherty MM, Charman WN "The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?" Clin Pharmacokinet 41 (2002): 235-53. [PMID: 11978143]
22	Product Information. Nuvigil (armodafinil). Cephalon Inc, West Chester, PA.
23	Product Information. Provigil (modafinil). Cephalon, Inc, West Chester, PA.
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25	Robertson P, Decory HH, Madan A, Parkinson A "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos 28 (2000): 664-71. [PMID: 10820139]

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